PICRUSt Stratified Analyses - Prevotella spp. (genus level only)

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Last updated: 2021-05-20

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Rmd	5a00a1b	noah-padgett	2021-04-29	updated figured and stuff
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Rmd	ea63e54	noah-padgett	2021-04-15	updated picrust results
html	ea63e54	noah-padgett	2021-04-15	updated picrust results

---

i. Mean relative abundance in Tumors

ii. Standard error of mean in Tumors

iii. Mean relative abundance in Non-tumors

iv. Standard error of mean in Non-tumors

v. GLM differential abundance analysis between Tumor vs Non-tumor (Patient=Fixed effect)
  1. P-value
  2. FDR corrected q-value
vi. GLMM differential abundance analysis between Tumor vs Non-tumor (Patient=Random Effect)
  1.P-value
  2. FDR corrected q-value

Part 1 EC Data

# note: must rename function to func (or something else) because "function" is a reserved name in R and can't be used.

descriptions <- readr::read_tsv("data/PICRUST/ec_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.

colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/EC_prevo.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`1.S37.Jun172016`:`99.D01.S37.Jun232016`,.fns = sum))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`1.S37.Jun172016`:`99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  )
d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)

Joining, by = "ID"

Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object

mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(ID) %>%
  mutate(
    dem = ifelse(sum(Abundance)==0, 1, sum(Abundance)),
    RelAbundance = Abundance/dem*100) %>%
  ungroup()%>%
  group_by(description)%>%
  mutate(avgRA = mean(RelAbundance))

Abundance

I needed to change from relative abundance to abundance due to so many individuals having 0 counts for all descriptions.

d <- mydata %>%
  filter(description=="DNA-directed DNA polymerase")

t.test(d$RelAbundance ~ d$tumor.cat)

    Welch Two Sample t-test

data:  d$RelAbundance by d$tumor.cat
t = -1.61, df = 147, p-value = 0.11
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 -0.42507  0.04277
sample estimates:
mean in group Non-Tumor     mean in group Tumor 
                 1.1167                  1.3079 

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(RelAbundance),
            Overall.SE = sd(RelAbundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(RelAbundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra <- left_join(tb.ra1, tb.ra2m)

Joining, by = "description"

tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )


kable(tb.ra, format="html", digits=5, caption="Stratefied EC Data - Prevotella spp. (genus level only): Average RelAbundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")

Stratefied EC Data - Prevotella spp. (genus level only): Average RelAbundance of Each Description (sorted in descending order)

description	Overall Mean	Overall SE	Tumor Mean	Tumor Var	Tumor SE	Tumor Ng	Non-Tumor Mean	Non-Tumor Var	Non-Tumor SE	Non-Tumor Ng	SEpooled	t	df	p	fdr_p
NADH:ubiquinone reductase (H(+)-translocating)	1.31524	0.06542	1.43681	0.58016	0.09447	65	1.23027	0.73253	0.08875	93	0.12962	1.59341	147.105	0.11322	0.22225
DNA helicase	1.27066	0.06326	1.38024	0.53715	0.09091	65	1.19407	0.69089	0.08619	93	0.12527	1.48620	147.735	0.13936	0.25058
Peptidylprolyl isomerase	1.25121	0.06244	1.37574	0.53377	0.09062	65	1.16417	0.66135	0.08433	93	0.12379	1.70914	146.443	0.08954	0.22225
DNA-directed DNA polymerase	1.19536	0.05968	1.30787	0.48665	0.08653	65	1.11672	0.60663	0.08076	93	0.11836	1.61493	146.658	0.10848	0.22225
2-oxoglutarate synthase	0.75694	0.03781	0.82018	0.19183	0.05433	65	0.71273	0.24720	0.05156	93	0.07490	1.43463	147.798	0.15350	0.26690
DNA topoisomerase	0.54874	0.03003	0.59546	0.12760	0.04431	65	0.51609	0.15177	0.04040	93	0.05996	1.32379	144.952	0.18766	0.30606
2-oxoacid oxidoreductase (ferredoxin)	0.49389	0.02500	0.53282	0.08437	0.03603	65	0.46668	0.10797	0.03407	93	0.04959	1.33376	147.566	0.18434	0.30321
Site-specific DNA-methyltransferase (adenine-specific)	0.47921	0.02528	0.51718	0.08530	0.03623	65	0.45267	0.11122	0.03458	93	0.05008	1.28794	148.186	0.19977	0.32220
Type I site-specific deoxyribonuclease	0.42086	0.02698	0.43782	0.11246	0.04160	65	0.40901	0.11768	0.03557	93	0.05473	0.52639	139.822	0.59945	0.69416
Beta-galactosidase	0.40945	0.02341	0.43686	0.07635	0.03427	65	0.39028	0.09374	0.03175	93	0.04672	0.99706	146.115	0.32038	0.43845
Alpha-L-fucosidase	0.40586	0.02201	0.43435	0.06588	0.03184	65	0.38595	0.08381	0.03002	93	0.04376	1.10621	147.363	0.27044	0.40253
DNA-directed RNA polymerase	0.39996	0.02003	0.43885	0.05537	0.02919	65	0.37278	0.06781	0.02700	93	0.03976	1.66180	146.025	0.09870	0.22225
23S rRNA pseudouridine(1911/1915/1917) synthase	0.39457	0.01963	0.43104	0.05221	0.02834	65	0.36908	0.06593	0.02663	93	0.03889	1.59341	147.105	0.11322	0.22225
C-terminal processing peptidase	0.39457	0.01963	0.43104	0.05221	0.02834	65	0.36908	0.06593	0.02663	93	0.03889	1.59341	147.105	0.11322	0.22225
Beta-N-acetylhexosaminidase	0.37051	0.02348	0.40339	0.08646	0.03647	65	0.34752	0.08718	0.03062	93	0.04762	1.17335	138.236	0.24267	0.37372
Long-chain-fatty-acid–CoA ligase	0.36482	0.01875	0.39036	0.04622	0.02667	65	0.34697	0.06182	0.02578	93	0.03709	1.16969	149.002	0.24399	0.37472
[Formate-C-acetyltransferase]-activating enzyme	0.35029	0.01795	0.38326	0.04396	0.02601	65	0.32725	0.05503	0.02433	93	0.03561	1.57263	146.805	0.11796	0.22842
Ribonucleoside-diphosphate reductase	0.31527	0.01747	0.35311	0.04417	0.02607	65	0.28883	0.04985	0.02315	93	0.03486	1.84371	142.922	0.06730	0.22225
Glutathione peroxidase	0.30699	0.01633	0.33469	0.03788	0.02414	65	0.28763	0.04465	0.02191	93	0.03260	1.44346	144.610	0.15105	0.26607
Undecaprenyl-diphosphate phosphatase	0.29978	0.01534	0.32305	0.03138	0.02197	65	0.28352	0.04100	0.02100	93	0.03039	1.30064	148.249	0.19540	0.31602
Alpha-amylase	0.28930	0.01515	0.31881	0.03192	0.02216	65	0.26867	0.03865	0.02038	93	0.03011	1.66497	145.606	0.09807	0.22225
S-adenosylmethionine:tRNA ribosyltransferase-isomerase	0.26844	0.01354	0.29517	0.02567	0.01987	65	0.24975	0.03070	0.01817	93	0.02693	1.68701	145.154	0.09375	0.22225
H(+)-transporting two-sector ATPase	0.26619	0.01332	0.28820	0.02337	0.01896	65	0.25081	0.03102	0.01826	93	0.02633	1.42001	148.764	0.15770	0.27184
Peroxiredoxin	0.26584	0.01334	0.28951	0.02403	0.01923	65	0.24930	0.03058	0.01813	93	0.02643	1.52172	147.373	0.13022	0.23785
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	0.26498	0.01320	0.29007	0.02375	0.01911	65	0.24744	0.02968	0.01786	93	0.02616	1.62961	146.746	0.10533	0.22225
GTP diphosphokinase	0.26463	0.01318	0.28930	0.02361	0.01906	65	0.24739	0.02967	0.01786	93	0.02612	1.60449	146.937	0.11075	0.22225
Mannose-1-phosphate guanylyltransferase	0.26337	0.01310	0.28814	0.02335	0.01895	65	0.24605	0.02930	0.01775	93	0.02597	1.62068	146.893	0.10723	0.22225
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
Dipeptidyl-peptidase IV	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
DNA topoisomerase (ATP-hydrolyzing)	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
Exodeoxyribonuclease VII	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
Fumarate reductase (quinol)	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
IMP cyclohydrolase	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
Phenylalanine–tRNA ligase	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
Phosphoribosylaminoimidazolecarboxamide formyltransferase	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
Ribonuclease H	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
Succinate dehydrogenase (quinone)	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
tRNA dimethylallyltransferase	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
Uridine kinase	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
XTP/dITP diphosphatase	0.26305	0.01308	0.28736	0.02321	0.01889	65	0.24605	0.02930	0.01775	93	0.02592	1.59341	147.105	0.11322	0.22225
Xaa-Pro aminopeptidase	0.26200	0.01307	0.28485	0.02318	0.01888	65	0.24602	0.02929	0.01775	93	0.02592	1.49854	147.131	0.13613	0.24787
5’-nucleotidase	0.25993	0.01298	0.28443	0.02293	0.01878	65	0.24281	0.02874	0.01758	93	0.02573	1.61809	146.846	0.10779	0.22225
Bleomycin hydrolase	0.25835	0.01291	0.28250	0.02269	0.01868	65	0.24147	0.02847	0.01750	93	0.02560	1.60278	146.884	0.11113	0.22225
DNA (cytosine-5-)-methyltransferase	0.25690	0.01515	0.27995	0.03447	0.02303	65	0.24078	0.03728	0.02002	93	0.03052	1.28362	141.201	0.20138	0.32298
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing)	0.25682	0.01303	0.28151	0.02326	0.01892	65	0.23956	0.02889	0.01762	93	0.02585	1.62225	146.526	0.10690	0.22225
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)	0.25506	0.01408	0.26873	0.02734	0.02051	65	0.24552	0.03424	0.01919	93	0.02808	0.82654	146.819	0.40984	0.53325
Phosphoglycolate phosphatase	0.25456	0.01353	0.27916	0.02652	0.02020	65	0.23737	0.03017	0.01801	93	0.02706	1.54419	143.238	0.12475	0.23196
Peptidyl-dipeptidase Dcp	0.25241	0.01308	0.27698	0.02417	0.01928	65	0.23524	0.02861	0.01754	93	0.02607	1.60113	144.770	0.11153	0.22225
Coproporphyrinogen dehydrogenase	0.25017	0.01274	0.27182	0.02251	0.01861	65	0.23503	0.02757	0.01722	93	0.02535	1.45116	146.021	0.14888	0.26524
Dephospho-CoA kinase	0.24817	0.01256	0.27105	0.02146	0.01817	65	0.23218	0.02698	0.01703	93	0.02490	1.56087	146.948	0.12071	0.23069
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	0.24625	0.01248	0.26719	0.02119	0.01805	65	0.23162	0.02671	0.01695	93	0.02476	1.43634	147.050	0.15303	0.26690
Aldose 1-epimerase	0.24621	0.01249	0.26468	0.02106	0.01800	65	0.23331	0.02698	0.01703	93	0.02478	1.26589	147.605	0.20755	0.32833
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	0.24568	0.01243	0.26525	0.02088	0.01792	65	0.23200	0.02670	0.01694	93	0.02466	1.34791	147.538	0.17975	0.29652
Methionyl aminopeptidase	0.24039	0.01230	0.26134	0.02080	0.01789	65	0.22576	0.02578	0.01665	93	0.02444	1.45601	146.454	0.14753	0.26364
Aspartate kinase	0.22979	0.01190	0.24660	0.01916	0.01717	65	0.21805	0.02449	0.01623	93	0.02362	1.20846	147.511	0.22880	0.35908
Thiamine-phosphate diphosphorylase	0.22949	0.01571	0.26310	0.03808	0.02420	65	0.20600	0.03872	0.02041	93	0.03166	1.80390	138.602	0.07342	0.22225
Glycerol-3-phosphate dehydrogenase	0.22509	0.01704	0.24874	0.04274	0.02564	65	0.20856	0.04790	0.02270	93	0.03424	1.17314	142.645	0.24270	0.37372
Fructokinase	0.22493	0.01183	0.24048	0.01942	0.01728	65	0.21407	0.02391	0.01603	93	0.02358	1.12021	146.213	0.26446	0.39772
Sialate O-acetylesterase	0.22155	0.01351	0.23055	0.02458	0.01945	65	0.21526	0.03202	0.01856	93	0.02688	0.56898	148.155	0.57023	0.67243
Aspartate transaminase	0.22082	0.01255	0.23782	0.02236	0.01855	65	0.20894	0.02654	0.01689	93	0.02509	1.15106	144.866	0.25160	0.38336
Glucosamine-6-phosphate deaminase	0.21876	0.01245	0.23740	0.02208	0.01843	65	0.20573	0.02605	0.01674	93	0.02490	1.27211	144.642	0.20538	0.32579
Leucine–tRNA ligase	0.21497	0.01138	0.23270	0.01785	0.01657	65	0.20258	0.02212	0.01542	93	0.02264	1.33024	146.458	0.18551	0.30364
Glutamate–ammonia ligase	0.20693	0.01103	0.22563	0.01726	0.01630	65	0.19386	0.02039	0.01481	93	0.02202	1.44298	144.688	0.15119	0.26607
Non-specific serine/threonine protein kinase	0.20554	0.01545	0.22919	0.03762	0.02406	65	0.18901	0.03751	0.02008	93	0.03134	1.28219	137.750	0.20193	0.32298
Uracil-DNA glycosylase	0.20190	0.01099	0.21993	0.01697	0.01616	65	0.18929	0.02036	0.01480	93	0.02191	1.39808	145.271	0.16422	0.28014
Glutamate dehydrogenase (NADP(+))	0.19792	0.01085	0.21825	0.01690	0.01612	65	0.18372	0.01950	0.01448	93	0.02167	1.59352	143.805	0.11324	0.22225
Glycine dehydrogenase (aminomethyl-transferring)	0.19667	0.01254	0.21339	0.02399	0.01921	65	0.18498	0.02537	0.01652	93	0.02534	1.12160	140.261	0.26395	0.39772
Succinate–CoA ligase (ADP-forming)	0.19002	0.01230	0.20732	0.02325	0.01891	65	0.17793	0.02426	0.01615	93	0.02487	1.18177	139.709	0.23930	0.37147
Beta-glucosidase	0.18843	0.01915	0.17968	0.04865	0.02736	65	0.19454	0.06496	0.02643	93	0.03804	-0.39072	148.951	0.69656	0.77560
Hydroxymethylpyrimidine kinase	0.18621	0.01054	0.20880	0.01665	0.01600	65	0.17042	0.01778	0.01383	93	0.02115	1.81471	140.683	0.07170	0.22225
Phosphomethylpyrimidine kinase	0.18621	0.01054	0.20880	0.01665	0.01600	65	0.17042	0.01778	0.01383	93	0.02115	1.81471	140.683	0.07170	0.22225
Serine O-acetyltransferase	0.18128	0.01054	0.19925	0.01615	0.01576	65	0.16871	0.01833	0.01404	93	0.02111	1.44679	143.154	0.15014	0.26607
Signal peptidase I	0.17830	0.01102	0.19862	0.02023	0.01764	65	0.16410	0.01817	0.01398	93	0.02251	1.53344	133.085	0.12754	0.23443
3-oxoacyl-[acyl-carrier-protein] reductase	0.17707	0.00962	0.18460	0.01170	0.01342	65	0.17181	0.01674	0.01342	93	0.01897	0.67408	150.964	0.50129	0.61233
Fumarate hydratase	0.17270	0.01097	0.19072	0.01794	0.01661	65	0.16011	0.01958	0.01451	93	0.02206	1.38772	141.565	0.16740	0.28014
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	0.17019	0.00923	0.17711	0.01056	0.01274	65	0.16535	0.01555	0.01293	93	0.01816	0.64816	151.730	0.51786	0.62597
Alpha-galactosidase	0.16998	0.01108	0.18309	0.01759	0.01645	65	0.16082	0.02066	0.01491	93	0.02220	1.00322	144.483	0.31743	0.43845
DNA-(apurinic or apyrimidinic site) lyase	0.16895	0.00926	0.18686	0.01238	0.01380	65	0.15643	0.01413	0.01233	93	0.01850	1.64511	143.375	0.10214	0.22225
Exodeoxyribonuclease III	0.16895	0.00926	0.18686	0.01238	0.01380	65	0.15643	0.01413	0.01233	93	0.01850	1.64511	143.375	0.10214	0.22225
Glucokinase	0.16874	0.00946	0.18300	0.01311	0.01420	65	0.15878	0.01478	0.01260	93	0.01899	1.27551	142.870	0.20420	0.32481
Asparaginase	0.16639	0.00926	0.18087	0.01215	0.01367	65	0.15627	0.01443	0.01246	93	0.01849	1.32988	144.920	0.18565	0.30364
Serine-type D-Ala-D-Ala carboxypeptidase	0.15720	0.00852	0.16929	0.00979	0.01227	65	0.14875	0.01260	0.01164	93	0.01691	1.21410	147.758	0.22665	0.35757
O-acetylhomoserine aminocarboxypropyltransferase	0.15553	0.01046	0.16240	0.01587	0.01563	65	0.15072	0.01842	0.01407	93	0.02103	0.55497	144.006	0.57977	0.67953
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	0.15516	0.00856	0.16687	0.00948	0.01208	65	0.14698	0.01298	0.01181	93	0.01690	1.17734	149.705	0.24093	0.37299
Acid phosphatase	0.15166	0.01170	0.16649	0.02111	0.01802	65	0.14130	0.02197	0.01537	93	0.02368	1.06392	139.586	0.28920	0.41967
2’,3’-cyclic-nucleotide 2’-phosphodiesterase	0.15127	0.00807	0.16172	0.00857	0.01148	65	0.14397	0.01146	0.01110	93	0.01597	1.11142	149.010	0.26818	0.40019
3’-nucleotidase	0.15127	0.00807	0.16172	0.00857	0.01148	65	0.14397	0.01146	0.01110	93	0.01597	1.11142	149.010	0.26818	0.40019
1-deoxy-D-xylulose-5-phosphate synthase	0.15048	0.00815	0.16622	0.00996	0.01238	65	0.13948	0.01069	0.01072	93	0.01638	1.63320	140.871	0.10466	0.22225
N-acetylmuramoyl-L-alanine amidase	0.14847	0.00807	0.16052	0.00894	0.01173	65	0.14004	0.01116	0.01096	93	0.01605	1.27613	146.725	0.20393	0.32481
Mannan endo-1,4-beta-mannosidase	0.14690	0.01095	0.14658	0.01464	0.01501	65	0.14713	0.02216	0.01544	93	0.02153	-0.02577	152.403	0.97947	0.97947
Beta-ketoacyl-[acyl-carrier-protein] synthase III	0.14634	0.00806	0.16469	0.01083	0.01291	65	0.13350	0.00956	0.01014	93	0.01641	1.90036	132.300	0.05956	0.22225
Cadmium-exporting ATPase	0.14419	0.00787	0.16093	0.00957	0.01213	65	0.13249	0.00972	0.01022	93	0.01587	1.79231	138.576	0.07527	0.22225
Dihydrofolate reductase	0.14419	0.00787	0.16093	0.00957	0.01213	65	0.13249	0.00972	0.01022	93	0.01587	1.79231	138.576	0.07527	0.22225
GTP cyclohydrolase I	0.14419	0.00787	0.16093	0.00957	0.01213	65	0.13249	0.00972	0.01022	93	0.01587	1.79231	138.576	0.07527	0.22225
Zinc-exporting ATPase	0.14419	0.00787	0.16093	0.00957	0.01213	65	0.13249	0.00972	0.01022	93	0.01587	1.79231	138.576	0.07527	0.22225
8-oxo-dGTP diphosphatase	0.14331	0.01023	0.15438	0.01629	0.01583	65	0.13558	0.01672	0.01341	93	0.02075	0.90634	138.994	0.36632	0.48647
Cu(2+)-exporting ATPase	0.14329	0.00767	0.15706	0.00807	0.01114	65	0.13366	0.01001	0.01037	93	0.01522	1.53766	146.494	0.12629	0.23361
Methionine synthase	0.14305	0.00983	0.15178	0.01518	0.01528	65	0.13695	0.01537	0.01286	93	0.01997	0.74295	138.413	0.45877	0.57998
Glutamate synthase (NADH)	0.14154	0.00833	0.14871	0.00960	0.01216	65	0.13654	0.01196	0.01134	93	0.01662	0.73214	146.631	0.46525	0.58434
Glutamate synthase (NADPH)	0.14154	0.00833	0.14871	0.00960	0.01216	65	0.13654	0.01196	0.01134	93	0.01662	0.73214	146.631	0.46525	0.58434
D-Ala-D-Ala dipeptidase	0.14098	0.00800	0.15580	0.01023	0.01254	65	0.13063	0.00989	0.01031	93	0.01624	1.55015	136.396	0.12342	0.23196
Triose-phosphate isomerase	0.13928	0.00722	0.15330	0.00750	0.01074	65	0.12948	0.00859	0.00961	93	0.01441	1.65315	143.515	0.10049	0.22225
3-deoxy-manno-octulosonate cytidylyltransferase	0.13921	0.00722	0.15285	0.00741	0.01068	65	0.12967	0.00869	0.00967	93	0.01440	1.60931	144.393	0.10973	0.22225
Methionine adenosyltransferase	0.13921	0.00722	0.15285	0.00741	0.01068	65	0.12967	0.00869	0.00967	93	0.01440	1.60931	144.393	0.10973	0.22225
Cob(I)yrinic acid a,c-diamide adenosyltransferase	0.13912	0.00828	0.14917	0.01019	0.01252	65	0.13210	0.01125	0.01100	93	0.01667	1.02447	142.039	0.30735	0.43845
Dihydroorotase	0.13691	0.00714	0.15149	0.00757	0.01079	65	0.12672	0.00823	0.00941	93	0.01432	1.73024	141.440	0.08577	0.22225
Endopeptidase La	0.13691	0.00714	0.15149	0.00757	0.01079	65	0.12672	0.00823	0.00941	93	0.01432	1.73024	141.440	0.08577	0.22225
Isoleucine–tRNA ligase	0.13691	0.00714	0.15149	0.00757	0.01079	65	0.12672	0.00823	0.00941	93	0.01432	1.73024	141.440	0.08577	0.22225
Phosphoribosylformylglycinamidine synthase	0.13691	0.00714	0.15149	0.00757	0.01079	65	0.12672	0.00823	0.00941	93	0.01432	1.73024	141.440	0.08577	0.22225
Aspartate ammonia-lyase	0.13596	0.00756	0.14844	0.00723	0.01054	65	0.12724	0.01018	0.01046	93	0.01485	1.42750	150.544	0.15551	0.26958
23S rRNA pseudouridine(746) synthase	0.13565	0.00730	0.14895	0.00778	0.01094	65	0.12636	0.00875	0.00970	93	0.01462	1.54553	142.761	0.12443	0.23196
tRNA pseudouridine(32) synthase	0.13565	0.00730	0.14895	0.00778	0.01094	65	0.12636	0.00875	0.00970	93	0.01462	1.54553	142.761	0.12443	0.23196
UDP-glucose 4-epimerase	0.13496	0.00690	0.14738	0.00648	0.00998	65	0.12627	0.00814	0.00936	93	0.01368	1.54295	146.936	0.12499	0.23196
Transketolase	0.13469	0.00682	0.14755	0.00647	0.00997	65	0.12570	0.00785	0.00918	93	0.01356	1.61166	145.688	0.10920	0.22225
16S rRNA (cytidine(1402)-2’-O)-methyltransferase	0.13464	0.00688	0.14661	0.00639	0.00992	65	0.12627	0.00814	0.00936	93	0.01363	1.49157	147.395	0.13795	0.24960
3’(2’),5’-bisphosphate nucleotidase	0.13464	0.00688	0.14661	0.00639	0.00992	65	0.12627	0.00814	0.00936	93	0.01363	1.49157	147.395	0.13795	0.24960
3-deoxy-manno-octulosonate-8-phosphatase	0.13311	0.00665	0.14562	0.00605	0.00964	65	0.12436	0.00753	0.00900	93	0.01319	1.61107	146.640	0.10931	0.22225
Amidophosphoribosyltransferase	0.13276	0.00663	0.14516	0.00597	0.00959	65	0.12410	0.00751	0.00898	93	0.01314	1.60303	146.932	0.11107	0.22225
UDP-glucose 6-dehydrogenase	0.13276	0.00663	0.14516	0.00597	0.00959	65	0.12410	0.00751	0.00898	93	0.01314	1.60303	146.932	0.11107	0.22225
3,4-dihydroxy-2-butanone-4-phosphate synthase	0.13260	0.00668	0.14619	0.00643	0.00994	65	0.12311	0.00734	0.00888	93	0.01333	1.73100	143.370	0.08560	0.22225
Histidine kinase	0.13258	0.00668	0.14619	0.00643	0.00994	65	0.12306	0.00733	0.00888	93	0.01333	1.73494	143.337	0.08490	0.22225
Uroporphyrinogen-III synthase	0.13254	0.00663	0.14368	0.00580	0.00945	65	0.12475	0.00767	0.00908	93	0.01311	1.44451	148.651	0.15070	0.26607
Phosphoribosylglycinamide formyltransferase	0.13244	0.00661	0.14438	0.00589	0.00952	65	0.12410	0.00751	0.00898	93	0.01309	1.55023	147.450	0.12323	0.23196
GTP cyclohydrolase II	0.13155	0.00654	0.14368	0.00580	0.00945	65	0.12308	0.00733	0.00888	93	0.01296	1.58937	147.133	0.11412	0.22289
(2E,6E)-farnesyl diphosphate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
(Kdo)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
(Kdo)(2)-lipid IV(A) (2-8) 3-deoxy-D-manno-octulosonic acid transferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
(Kdo)(3)-lipid IV(A) (2-4) 3-deoxy-D-manno-octulosonic acid transferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
[Acyl-carrier-protein] S-malonyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
1-acylglycerol-3-phosphate O-acyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
1-deoxy-D-xylulose-5-phosphate reductoisomerase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
1,4-alpha-glucan branching enzyme	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
1,4-dihydroxy-2-naphthoate polyprenyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
1,4-dihydroxy-2-naphthoyl-CoA synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
16S rRNA (cytosine(1402)-N(4))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
16S rRNA (guanine(527)-N(7))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
16S rRNA (uracil(1498)-N(3))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
2-iminobutanoate/2-iminopropanoate deaminase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
23S rRNA (adenine(2503)-C(2))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
23S rRNA (cytosine(1962)-C(5))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
23S rRNA (uracil(1939)-C(5))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
23S rRNA pseudouridine(2605) synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
3-dehydroquinate dehydratase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
3-dehydroquinate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
3-deoxy-8-phosphooctulonate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
3-phosphoshikimate 1-carboxyvinyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
4-alpha-glucanotransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
4-hydroxy-tetrahydrodipicolinate reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
4-hydroxy-tetrahydrodipicolinate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
4-hydroxythreonine-4-phosphate dehydrogenase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
5-(carboxyamino)imidazole ribonucleotide mutase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
5-amino-6-(5-phosphoribosylamino)uracil reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
5-formyltetrahydrofolate cyclo-ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
6-phosphofructokinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
6,7-dimethyl-8-ribityllumazine synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
7-cyano-7-deazaguanine synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Acetate kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
acetylglucosaminyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Adenine phosphoribosyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Adenosylhomocysteine nucleosidase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Adenylate kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Adenylosuccinate lyase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Adenylosuccinate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Alanine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Alanine racemase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
All-trans-octaprenyl-diphosphate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Aminoacyl-tRNA hydrolase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Arabinose-5-phosphate isomerase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Arginine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Arginine decarboxylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Asparagine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Aspartate–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Aspartate-semialdehyde dehydrogenase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Aspartate carbamoyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Beta-ketoacyl-[acyl-carrier-protein] synthase II	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Biotin–[acetyl-CoA-carboxylase] ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Branched-chain-amino-acid transaminase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Carboxynorspermidine decarboxylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
CDP-diacylglycerol–serine O-phosphatidyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Chorismate mutase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Chorismate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Crossover junction endodeoxyribonuclease	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
CTP synthase (glutamine hydrolyzing)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Cysteine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Cysteine desulfurase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Cytidine deaminase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
D-alanine–D-alanine ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
dCMP deaminase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Demethylmenaquinone methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Deoxyribose-phosphate aldolase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
dGTPase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Diamine N-acetyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Diaminohydroxyphosphoribosylaminopyrimidine deaminase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Dihydrofolate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Dihydroneopterin aldolase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Dihydroorotate dehydrogenase (NAD(+))	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Dihydropteroate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Dimethylallyltranstransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Dipeptidyl-peptidase III	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Diphosphate–fructose-6-phosphate 1-phosphotransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
diphosphate specific)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
DNA ligase (NAD(+))	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Dolichyl-phosphate beta-D-mannosyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
dTDP-4-dehydrorhamnose 3,5-epimerase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
dTDP-4-dehydrorhamnose reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
dTDP-glucose 4,6-dehydratase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
dUTP diphosphatase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Endopeptidase Clp	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Epoxyqueuosine reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
FAD synthetase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
FMN reductase (NAD(P)H)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Fructose-bisphosphatase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Fructose-bisphosphate aldolase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
GDP-L-fucose synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
GDP-mannose 4,6-dehydratase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Geranylgeranyl diphosphate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glucose-1-phosphate thymidylyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glucose-6-phosphate isomerase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glutamate–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glutamate racemase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glutamine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glycerate dehydrogenase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glycerol-3-phosphate dehydrogenase (NAD(P)(+))	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glycine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glycine hydroxymethyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Glycogen phosphorylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
GMP synthase (glutamine-hydrolyzing)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Guanylate kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Histidine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Hypoxanthine phosphoribosyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
IMP dehydrogenase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Iron-chelate-transporting ATPase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Isochorismate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Kdo(2)-lipid IV(A) lauroyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
L-serine ammonia-lyase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
L-threonylcarbamoyladenylate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Lipid-A-disaccharide synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Lysine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Malate dehydrogenase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Mannose-6-phosphate isomerase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Methenyltetrahydrofolate cyclohydrolase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Methionine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Methionyl-tRNA formyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Methylated-DNA–[protein]-cysteine S-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Methylenetetrahydrofolate dehydrogenase (NADP(+))	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
N-carbamoylputrescine amidase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
N(6)-L-threonylcarbamoyladenine synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
NAD(+) diphosphatase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
NAD(+) kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
NAD(+) synthase (glutamine-hydrolyzing)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
NAD(P)H-hydrate epimerase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Nicotinamide-nucleotide amidase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Nicotinate-nucleotide adenylyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Oligonucleotidase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Orotate phosphoribosyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Orotidine-5’-phosphate decarboxylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Pantetheine-phosphate adenylyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Pantothenate kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Peptide-methionine (R)-S-oxide reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Peptide-methionine (S)-S-oxide reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Peptide chain release factor N(5)-glutamine methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Peptide deformylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphate acetyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphatidate cytidylyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphatidylserine decarboxylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phospho-N-acetylmuramoyl-pentapeptide-transferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphoenolpyruvate carboxykinase (ATP)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphoglycerate kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphomannomutase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphopyruvate hydratase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphoribosylamine–glycine ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphoribosylaminoimidazolesuccinocarboxamide synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Phosphoribosylformylglycinamidine cyclo-ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Polyribonucleotide nucleotidyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
PreQ(1) synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Proline–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Protein-disulfide reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Purine-nucleoside phosphorylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Pyruvate carboxylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Pyruvate kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Pyruvate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Pyruvate, phosphate dikinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Riboflavin kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Riboflavin synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Ribonuclease P	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Ribonuclease Z	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Ribonucleoside-triphosphate reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Ribose-5-phosphate isomerase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Ribose-phosphate diphosphokinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Ribulose-phosphate 3-epimerase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
RNA helicase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Saccharopine dehydrogenase (NAD(+), L-lysine-forming)	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Selenocysteine lyase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Serine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Shikimate dehydrogenase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Shikimate kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Signal peptidase II	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Starch synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Tetraacyldisaccharide 4’-kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Tetrahydrofolate synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Thiamine-phosphate kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Thioredoxin-disulfide reductase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Threonine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Thymidine kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Tripeptide aminopeptidase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA-guanine(34) transglycosylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA (guanine(37)-N(1))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA (guanine(46)-N(7))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA pseudouridine(38-40) synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA pseudouridine(55) synthase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA(adenine(34)) deaminase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
tRNA(Ile)-lysidine synthetase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Tryptophan–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Tyrosine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UDP-2,3-diacylglucosamine diphosphatase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UDP-N-acetylmuramate–L-alanine ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UDP-N-acetylmuramate dehydrogenase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UMP kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
UMP/CMP kinase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Uracil phosphoribosyltransferase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Uridine phosphorylase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Valine–tRNA ligase	0.13152	0.00654	0.14368	0.00580	0.00945	65	0.12303	0.00733	0.00888	93	0.01296	1.59341	147.105	0.11322	0.22225
Nicotinate phosphoribosyltransferase	0.13120	0.00654	0.14291	0.00579	0.00944	65	0.12303	0.00733	0.00888	93	0.01296	1.53448	147.178	0.12706	0.23429
3-methyl-2-oxobutanoate hydroxymethyltransferase	0.13051	0.00653	0.14368	0.00580	0.00945	65	0.12130	0.00727	0.00884	93	0.01294	1.72959	146.821	0.08581	0.22225
Aspartate 1-decarboxylase	0.13051	0.00653	0.14368	0.00580	0.00945	65	0.12130	0.00727	0.00884	93	0.01294	1.72959	146.821	0.08581	0.22225
Pantoate–beta-alanine ligase (AMP-forming)	0.13051	0.00653	0.14368	0.00580	0.00945	65	0.12130	0.00727	0.00884	93	0.01294	1.72959	146.821	0.08581	0.22225
Phosphopantothenate–cysteine ligase	0.13051	0.00653	0.14368	0.00580	0.00945	65	0.12130	0.00727	0.00884	93	0.01294	1.72959	146.821	0.08581	0.22225
Phosphopantothenoylcysteine decarboxylase	0.13051	0.00653	0.14368	0.00580	0.00945	65	0.12130	0.00727	0.00884	93	0.01294	1.72959	146.821	0.08581	0.22225
Diaminopimelate dehydrogenase	0.12994	0.00650	0.14175	0.00573	0.00939	65	0.12169	0.00722	0.00881	93	0.01288	1.55743	147.030	0.12152	0.23069
Phosphoglycerate dehydrogenase	0.12994	0.00650	0.14175	0.00573	0.00939	65	0.12169	0.00722	0.00881	93	0.01288	1.55743	147.030	0.12152	0.23069
Phosphoserine transaminase	0.12994	0.00650	0.14175	0.00573	0.00939	65	0.12169	0.00722	0.00881	93	0.01288	1.55743	147.030	0.12152	0.23069
DNA-3-methyladenine glycosylase I	0.12967	0.00818	0.14355	0.00992	0.01235	65	0.11996	0.01089	0.01082	93	0.01642	1.43608	141.845	0.15318	0.26690
Protein-tyrosine-phosphatase	0.12922	0.00656	0.13975	0.00599	0.00960	65	0.12187	0.00732	0.00887	93	0.01307	1.36854	145.912	0.17325	0.28825
Nitrite reductase (cytochrome; ammonia-forming)	0.12914	0.00655	0.14040	0.00598	0.00959	65	0.12127	0.00726	0.00884	93	0.01304	1.46693	145.732	0.14455	0.25911
Bacterial non-heme ferritin	0.12841	0.00652	0.14075	0.00581	0.00946	65	0.11978	0.00722	0.00881	93	0.01293	1.62225	146.526	0.10690	0.22225
Enoyl-[acyl-carrier-protein] reductase (NADH)	0.12841	0.00652	0.14075	0.00581	0.00946	65	0.11978	0.00722	0.00881	93	0.01293	1.62225	146.526	0.10690	0.22225
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)	0.12841	0.00652	0.14075	0.00581	0.00946	65	0.11978	0.00722	0.00881	93	0.01293	1.62225	146.526	0.10690	0.22225
o-succinylbenzoate–CoA ligase	0.12841	0.00652	0.14075	0.00581	0.00946	65	0.11978	0.00722	0.00881	93	0.01293	1.62225	146.526	0.10690	0.22225
Phosphoribosylanthranilate isomerase	0.12841	0.00652	0.14075	0.00581	0.00946	65	0.11978	0.00722	0.00881	93	0.01293	1.62225	146.526	0.10690	0.22225
Ribonuclease III	0.12838	0.00661	0.14284	0.00577	0.00942	65	0.11827	0.00750	0.00898	93	0.01302	1.88826	148.110	0.06095	0.22225
Hydroxylamine reductase	0.12835	0.00663	0.14106	0.00611	0.00969	65	0.11947	0.00740	0.00892	93	0.01317	1.63906	145.626	0.10336	0.22225
Formate C-acetyltransferase	0.12788	0.00651	0.13924	0.00591	0.00954	65	0.11993	0.00715	0.00877	93	0.01296	1.48990	145.571	0.13842	0.24966
Thymidylate synthase	0.12436	0.00780	0.13995	0.00938	0.01201	65	0.11346	0.00960	0.01016	93	0.01573	1.68383	138.907	0.09446	0.22225
Pyridoxal kinase	0.12404	0.00656	0.13981	0.00577	0.00942	65	0.11302	0.00728	0.00885	93	0.01292	2.07253	147.096	0.03996	0.22225
Thiamine diphosphokinase	0.12311	0.00666	0.13730	0.00606	0.00966	65	0.11319	0.00750	0.00898	93	0.01319	1.82792	146.407	0.06960	0.22225
Galactokinase	0.12270	0.00649	0.13355	0.00607	0.00966	65	0.11512	0.00700	0.00868	93	0.01299	1.41925	143.782	0.15799	0.27184
Maltose O-acetyltransferase	0.12179	0.00694	0.13319	0.00697	0.01036	65	0.11382	0.00798	0.00926	93	0.01390	1.39377	143.496	0.16554	0.28014
Protoporphyrinogen oxidase	0.12128	0.00647	0.13168	0.00615	0.00973	65	0.11401	0.00687	0.00859	93	0.01298	1.36155	142.474	0.17549	0.29031
Formate–tetrahydrofolate ligase	0.11885	0.00645	0.12643	0.00596	0.00958	65	0.11356	0.00700	0.00868	93	0.01292	0.99605	144.472	0.32089	0.43845
S-ribosylhomocysteine lyase	0.11885	0.00645	0.12643	0.00596	0.00958	65	0.11356	0.00700	0.00868	93	0.01292	0.99605	144.472	0.32089	0.43845
Glycine C-acetyltransferase	0.11846	0.00921	0.12432	0.01230	0.01376	65	0.11436	0.01428	0.01239	93	0.01851	0.53816	144.021	0.59130	0.68747
Fructan beta-fructosidase	0.11780	0.00646	0.12392	0.00607	0.00966	65	0.11352	0.00700	0.00867	93	0.01298	0.80097	143.778	0.42447	0.54767
Glutamine–fructose-6-phosphate transaminase (isomerizing)	0.11658	0.00640	0.12527	0.00595	0.00956	65	0.11050	0.00680	0.00855	93	0.01283	1.15136	143.458	0.25150	0.38336
Pullulanase	0.11574	0.00639	0.12350	0.00587	0.00951	65	0.11031	0.00684	0.00857	93	0.01280	1.03035	144.133	0.30457	0.43662
Cystathionine beta-lyase	0.11424	0.00642	0.12004	0.00596	0.00957	65	0.11019	0.00694	0.00864	93	0.01290	0.76374	144.196	0.44627	0.56665
Tryptophan synthase	0.11201	0.00667	0.12059	0.00678	0.01022	65	0.10602	0.00720	0.00880	93	0.01348	1.08097	140.434	0.28157	0.41481
Calcium-transporting ATPase	0.11178	0.00646	0.12564	0.00591	0.00953	65	0.10208	0.00691	0.00862	93	0.01285	1.83311	144.317	0.06885	0.22225
Xanthine phosphoribosyltransferase	0.11178	0.00646	0.12564	0.00591	0.00953	65	0.10208	0.00691	0.00862	93	0.01285	1.83311	144.317	0.06885	0.22225
Histidinol-phosphate transaminase	0.11119	0.00761	0.12547	0.00963	0.01217	65	0.10121	0.00867	0.00966	93	0.01554	1.56112	133.194	0.12087	0.23069
NADH dehydrogenase	0.10992	0.00626	0.12016	0.00566	0.00933	65	0.10276	0.00651	0.00837	93	0.01253	1.38851	143.673	0.16713	0.28014
Prolyl oligopeptidase	0.10919	0.00643	0.11994	0.00599	0.00960	65	0.10167	0.00686	0.00859	93	0.01288	1.41847	143.501	0.15822	0.27184
1,4-beta-mannosyl-N-acetylglucosamine phosphorylase	0.10611	0.00622	0.11479	0.00544	0.00915	65	0.10005	0.00654	0.00838	93	0.01241	1.18814	145.316	0.23672	0.36844
Beta-1,4-mannooligosaccharide phosphorylase	0.10611	0.00622	0.11479	0.00544	0.00915	65	0.10005	0.00654	0.00838	93	0.01241	1.18814	145.316	0.23672	0.36844
Exo-alpha-sialidase	0.10611	0.00622	0.11479	0.00544	0.00915	65	0.10005	0.00654	0.00838	93	0.01241	1.18814	145.316	0.23672	0.36844
Phosphoserine phosphatase	0.10588	0.00621	0.11069	0.00590	0.00953	65	0.10252	0.00626	0.00820	93	0.01257	0.65026	140.403	0.51659	0.62597
N-acylglucosamine 2-epimerase	0.10506	0.00622	0.11229	0.00549	0.00919	65	0.10001	0.00654	0.00839	93	0.01244	0.98644	145.048	0.32556	0.44129
Nicotinamidase	0.10352	0.00641	0.12007	0.00568	0.00935	65	0.09195	0.00679	0.00855	93	0.01267	2.22025	145.147	0.02795	0.22225
Glycerate 3-kinase	0.10324	0.00626	0.11187	0.00577	0.00943	65	0.09721	0.00647	0.00834	93	0.01259	1.16435	142.641	0.24623	0.37716
Lipoyl synthase	0.10270	0.00675	0.10764	0.00616	0.00973	65	0.09925	0.00798	0.00926	93	0.01344	0.62467	147.985	0.53315	0.63648
Aspartate–ammonia ligase	0.10167	0.00606	0.10906	0.00539	0.00911	65	0.09650	0.00610	0.00810	93	0.01218	1.03020	143.011	0.30465	0.43662
N-acetylneuraminate lyase	0.10165	0.00621	0.10955	0.00562	0.00930	65	0.09613	0.00643	0.00831	93	0.01247	1.07638	143.475	0.28356	0.41481
Anthranilate synthase	0.10149	0.00677	0.11249	0.00714	0.01048	65	0.09379	0.00726	0.00883	93	0.01371	1.36425	138.581	0.17470	0.28983
Aminomethyltransferase	0.09833	0.00627	0.10670	0.00600	0.00961	65	0.09249	0.00634	0.00826	93	0.01267	1.12160	140.261	0.26395	0.39772
Dihydrolipoyl dehydrogenase	0.09833	0.00627	0.10670	0.00600	0.00961	65	0.09249	0.00634	0.00826	93	0.01267	1.12160	140.261	0.26395	0.39772
Diaminopimelate decarboxylase	0.09827	0.00620	0.10291	0.00568	0.00935	65	0.09502	0.00637	0.00828	93	0.01249	0.63226	142.698	0.52823	0.63322
Homoserine dehydrogenase	0.09827	0.00620	0.10291	0.00568	0.00935	65	0.09502	0.00637	0.00828	93	0.01249	0.63226	142.698	0.52823	0.63322
Homoserine O-succinyltransferase	0.09827	0.00620	0.10291	0.00568	0.00935	65	0.09502	0.00637	0.00828	93	0.01249	0.63226	142.698	0.52823	0.63322
Acetate–CoA ligase	0.09750	0.00609	0.10362	0.00538	0.00910	65	0.09323	0.00622	0.00818	93	0.01223	0.85001	143.874	0.39673	0.51736
Aminodeoxychorismate lyase	0.09591	0.00638	0.10577	0.00623	0.00979	65	0.08901	0.00652	0.00838	93	0.01288	1.30117	139.883	0.19534	0.31602
Aminodeoxychorismate synthase	0.09591	0.00638	0.10577	0.00623	0.00979	65	0.08901	0.00652	0.00838	93	0.01288	1.30117	139.883	0.19534	0.31602
Cysteine synthase	0.09515	0.00611	0.09999	0.00545	0.00916	65	0.09177	0.00625	0.00820	93	0.01229	0.66803	143.527	0.50519	0.61472
Butyrate kinase	0.09396	0.00628	0.10575	0.00591	0.00953	65	0.08573	0.00635	0.00827	93	0.01262	1.58715	140.984	0.11472	0.22289
Phosphate butyryltransferase	0.09396	0.00628	0.10575	0.00591	0.00953	65	0.08573	0.00635	0.00827	93	0.01262	1.58715	140.984	0.11472	0.22289
Inositol-3-phosphate synthase	0.09150	0.00632	0.10232	0.00612	0.00971	65	0.08394	0.00636	0.00827	93	0.01275	1.44143	139.489	0.15170	0.26617
L-aspartate oxidase	0.09142	0.00610	0.09922	0.00575	0.00941	65	0.08597	0.00596	0.00801	93	0.01235	1.07297	139.423	0.28514	0.41481
Nicotinate-nucleotide diphosphorylase (carboxylating)	0.09142	0.00610	0.09922	0.00575	0.00941	65	0.08597	0.00596	0.00801	93	0.01235	1.07297	139.423	0.28514	0.41481
Quinolinate synthase	0.09142	0.00610	0.09922	0.00575	0.00941	65	0.08597	0.00596	0.00801	93	0.01235	1.07297	139.423	0.28514	0.41481
Superoxide reductase	0.09092	0.00608	0.10212	0.00566	0.00933	65	0.08309	0.00589	0.00796	93	0.01227	1.55169	139.564	0.12300	0.23196
Levanase	0.08973	0.00605	0.09653	0.00531	0.00904	65	0.08498	0.00611	0.00810	93	0.01214	0.95181	143.645	0.34279	0.45837
Formimidoyltetrahydrofolate cyclodeaminase	0.08849	0.00612	0.09491	0.00587	0.00950	65	0.08401	0.00596	0.00800	93	0.01242	0.87711	138.526	0.38195	0.50033
Glutamate formimidoyltransferase	0.08849	0.00612	0.09491	0.00587	0.00950	65	0.08401	0.00596	0.00800	93	0.01242	0.87711	138.526	0.38195	0.50033
Histidine ammonia-lyase	0.08849	0.00612	0.09491	0.00587	0.00950	65	0.08401	0.00596	0.00800	93	0.01242	0.87711	138.526	0.38195	0.50033
Imidazolonepropionase	0.08849	0.00612	0.09491	0.00587	0.00950	65	0.08401	0.00596	0.00800	93	0.01242	0.87711	138.526	0.38195	0.50033
Urocanate hydratase	0.08849	0.00612	0.09491	0.00587	0.00950	65	0.08401	0.00596	0.00800	93	0.01242	0.87711	138.526	0.38195	0.50033
Inorganic diphosphatase	0.08744	0.00591	0.09291	0.00506	0.00882	65	0.08361	0.00585	0.00793	93	0.01186	0.78341	143.856	0.43467	0.55481
Hyaluronoglucosaminidase	0.08632	0.00600	0.09204	0.00513	0.00889	65	0.08232	0.00611	0.00811	93	0.01203	0.80811	145.011	0.42035	0.54448
Methylenetetrahydrofolate reductase (NAD(P)H)	0.08596	0.00597	0.08841	0.00521	0.00896	65	0.08425	0.00596	0.00801	93	0.01201	0.34644	143.443	0.72952	0.78152
Alpha-glucosidase	0.08199	0.00608	0.08999	0.00542	0.00913	65	0.07640	0.00611	0.00810	93	0.01221	1.11305	142.859	0.26756	0.40019
D-lactate dehydrogenase	0.08190	0.00588	0.09152	0.00527	0.00901	65	0.07519	0.00555	0.00773	93	0.01187	1.37612	140.110	0.17098	0.28530
Methylmalonyl-CoA mutase	0.08118	0.00588	0.08414	0.00495	0.00873	65	0.07911	0.00586	0.00794	93	0.01180	0.42622	144.760	0.67058	0.75392
Beta-ketoacyl-[acyl-carrier-protein] synthase I	0.07733	0.00880	0.06687	0.00925	0.01193	65	0.08464	0.01429	0.01240	93	0.01720	-1.03307	152.846	0.30320	0.43662
Glucose-1-phosphatase	0.07571	0.00585	0.08319	0.00527	0.00901	65	0.07048	0.00549	0.00768	93	0.01184	1.07334	139.615	0.28497	0.41481
2-dehydropantoate 2-reductase	0.07218	0.00569	0.07556	0.00499	0.00877	65	0.06981	0.00525	0.00751	93	0.01154	0.49861	139.998	0.61884	0.71093
Carbonate dehydratase	0.06596	0.00561	0.06865	0.00496	0.00874	65	0.06407	0.00501	0.00734	93	0.01141	0.40107	138.293	0.68898	0.76864
Arylsulfatase	0.06462	0.00559	0.06788	0.00483	0.00862	65	0.06235	0.00506	0.00738	93	0.01135	0.48679	139.872	0.62717	0.71907
Phosphomethylpyrimidine synthase	0.05938	0.00550	0.06998	0.00512	0.00887	65	0.05197	0.00445	0.00692	93	0.01125	1.60063	131.674	0.11186	0.22225
Galactoside O-acetyltransferase	0.05510	0.00526	0.06505	0.00463	0.00844	65	0.04815	0.00413	0.00667	93	0.01075	1.57117	132.804	0.11852	0.22875
Glycerol kinase	0.05310	0.00498	0.06225	0.00411	0.00795	65	0.04670	0.00374	0.00634	93	0.01017	1.52977	133.689	0.12844	0.23533
All-trans-retinol 13,14-reductase	0.05270	0.00683	0.04689	0.00605	0.00965	65	0.05676	0.00832	0.00946	93	0.01351	-0.73034	149.855	0.46632	0.58442
Prephenate dehydratase	0.05052	0.00514	0.04612	0.00384	0.00769	65	0.05360	0.00442	0.00690	93	0.01033	-0.72481	143.699	0.46975	0.58744
Cobaltochelatase	0.04497	0.00516	0.04929	0.00450	0.00832	65	0.04195	0.00403	0.00659	93	0.01061	0.69191	132.991	0.49020	0.60133
Type II site-specific deoxyribonuclease	0.04472	0.00629	0.05129	0.00637	0.00990	65	0.04013	0.00620	0.00816	93	0.01283	0.87038	136.686	0.38562	0.50400
Acetolactate synthase	0.04408	0.00703	0.04225	0.00713	0.01047	65	0.04537	0.00838	0.00949	93	0.01413	-0.22088	144.503	0.82549	0.85964
Superoxide dismutase	0.04350	0.00483	0.04591	0.00397	0.00781	65	0.04181	0.00352	0.00616	93	0.00995	0.41288	132.559	0.68036	0.76048
2-dehydro-3-deoxygluconokinase	0.04288	0.00676	0.03962	0.00599	0.00960	65	0.04516	0.00816	0.00937	93	0.01341	-0.41288	149.582	0.68028	0.76048
Indole-3-glycerol-phosphate synthase	0.04260	0.00465	0.04464	0.00345	0.00729	65	0.04118	0.00341	0.00606	93	0.00948	0.36572	137.392	0.71513	0.78152
Methylaspartate mutase	0.04118	0.00689	0.04704	0.00790	0.01103	65	0.03708	0.00724	0.00883	93	0.01412	0.70494	134.018	0.48207	0.59261
UDP-galactopyranose mutase	0.03809	0.00462	0.04235	0.00384	0.00768	65	0.03510	0.00307	0.00575	93	0.00959	0.75562	127.810	0.45127	0.57174
6-carboxytetrahydropterin synthase	0.03772	0.00470	0.04123	0.00380	0.00765	65	0.03527	0.00329	0.00595	93	0.00969	0.61468	131.421	0.53983	0.64050
6-pyruvoyltetrahydropterin synthase	0.03772	0.00470	0.04123	0.00380	0.00765	65	0.03527	0.00329	0.00595	93	0.00969	0.61468	131.421	0.53983	0.64050
23S rRNA (adenine(2085)-N(6))-dimethyltransferase	0.03742	0.00450	0.04318	0.00342	0.00726	65	0.03340	0.00304	0.00572	93	0.00924	1.05920	132.564	0.29143	0.42185
Alkaline phosphatase	0.03500	0.00452	0.03879	0.00380	0.00765	65	0.03235	0.00286	0.00554	93	0.00944	0.68113	124.877	0.49705	0.60844
Dipeptidase E	0.03360	0.00442	0.03313	0.00306	0.00686	65	0.03393	0.00313	0.00580	93	0.00898	-0.08951	138.957	0.92880	0.93202
Threonine ammonia-lyase	0.03274	0.00433	0.03606	0.00342	0.00726	65	0.03041	0.00267	0.00536	93	0.00902	0.62655	126.594	0.53209	0.63648
Arabinogalactan endo-beta-1,4-galactanase	0.03134	0.00420	0.03242	0.00293	0.00671	65	0.03058	0.00272	0.00540	93	0.00862	0.21316	134.569	0.83153	0.86282
Alpha-N-acetylglucosaminidase	0.02891	0.00615	0.02313	0.00488	0.00866	65	0.03296	0.00675	0.00852	93	0.01215	-0.80902	150.060	0.41978	0.54448
Glycerophosphodiester phosphodiesterase	0.02857	0.00456	0.02949	0.00349	0.00733	65	0.02793	0.00318	0.00585	93	0.00938	0.16583	133.714	0.86854	0.89481
N-acetylmuramic acid 6-phosphate etherase	0.02767	0.00404	0.02489	0.00210	0.00568	65	0.02962	0.00293	0.00562	93	0.00799	-0.59243	150.337	0.55445	0.65650
Arabinan endo-1,5-alpha-L-arabinosidase	0.02741	0.00387	0.02544	0.00207	0.00565	65	0.02878	0.00259	0.00527	93	0.00773	-0.43190	146.695	0.66645	0.75392
Diaminopimelate epimerase	0.02700	0.00381	0.02787	0.00223	0.00586	65	0.02639	0.00237	0.00505	93	0.00773	0.19060	140.398	0.84912	0.87636
LL-diaminopimelate aminotransferase	0.02700	0.00381	0.02787	0.00223	0.00586	65	0.02639	0.00237	0.00505	93	0.00773	0.19060	140.398	0.84912	0.87636
Glucuronate isomerase	0.02549	0.00394	0.02137	0.00177	0.00521	65	0.02838	0.00293	0.00561	93	0.00766	-0.91523	154.205	0.36150	0.48117
Alpha-D-xyloside xylohydrolase	0.02548	0.00379	0.02273	0.00187	0.00536	65	0.02740	0.00257	0.00526	93	0.00751	-0.62073	149.868	0.53572	0.63823
Threonine synthase	0.02519	0.00377	0.02196	0.00179	0.00524	65	0.02744	0.00258	0.00526	93	0.00743	-0.73860	151.197	0.46130	0.58190
Adenosylcobalamin/alpha-ribazole phosphatase	0.02388	0.00356	0.02068	0.00148	0.00477	65	0.02611	0.00238	0.00506	93	0.00695	-0.78102	153.646	0.43599	0.55481
Adenosylcobinamide-GDP ribazoletransferase	0.02388	0.00356	0.02068	0.00148	0.00477	65	0.02611	0.00238	0.00506	93	0.00695	-0.78102	153.646	0.43599	0.55481
Adenosylcobinamide-phosphate guanylyltransferase	0.02388	0.00356	0.02068	0.00148	0.00477	65	0.02611	0.00238	0.00506	93	0.00695	-0.78102	153.646	0.43599	0.55481
Adenosylcobinamide kinase	0.02388	0.00356	0.02068	0.00148	0.00477	65	0.02611	0.00238	0.00506	93	0.00695	-0.78102	153.646	0.43599	0.55481
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase	0.02388	0.00356	0.02068	0.00148	0.00477	65	0.02611	0.00238	0.00506	93	0.00695	-0.78102	153.646	0.43599	0.55481
(4S)-4-hydroxy-2-oxoglutarate aldolase	0.02303	0.00370	0.02112	0.00178	0.00524	65	0.02436	0.00245	0.00513	93	0.00733	-0.44125	149.826	0.65967	0.75335
2-dehydro-3-deoxy-phosphogluconate aldolase	0.02303	0.00370	0.02112	0.00178	0.00524	65	0.02436	0.00245	0.00513	93	0.00733	-0.44125	149.826	0.65967	0.75335
4-O-beta-D-mannosyl-D-glucose phosphorylase	0.02223	0.00353	0.01764	0.00141	0.00466	65	0.02544	0.00235	0.00503	93	0.00685	-1.13757	154.315	0.25706	0.39066
Dihydroxy-acid dehydratase	0.02204	0.00352	0.02112	0.00178	0.00524	65	0.02268	0.00209	0.00475	93	0.00707	-0.22088	144.503	0.82549	0.85964
Ketol-acid reductoisomerase (NADP(+))	0.02204	0.00352	0.02112	0.00178	0.00524	65	0.02268	0.00209	0.00475	93	0.00707	-0.22088	144.503	0.82549	0.85964
Gluconate 5-dehydrogenase	0.02203	0.00352	0.02117	0.00179	0.00525	65	0.02264	0.00209	0.00474	93	0.00707	-0.20778	144.246	0.83569	0.86559
Xylulokinase	0.02201	0.00351	0.02112	0.00178	0.00524	65	0.02264	0.00209	0.00474	93	0.00706	-0.21413	144.428	0.83074	0.86282
Alanine dehydrogenase	0.02190	0.00352	0.02066	0.00179	0.00524	65	0.02278	0.00209	0.00475	93	0.00707	-0.29945	144.413	0.76503	0.80245
Non-reducing end alpha-L-arabinofuranosidase	0.02141	0.00353	0.02120	0.00185	0.00533	65	0.02157	0.00207	0.00472	93	0.00712	-0.05203	142.617	0.95858	0.96024
Mannonate dehydratase	0.02109	0.00350	0.02042	0.00176	0.00521	65	0.02157	0.00207	0.00472	93	0.00703	-0.16304	144.482	0.87071	0.89546
Choline-phosphate cytidylyltransferase	0.02059	0.00344	0.02352	0.00198	0.00551	65	0.01854	0.00181	0.00441	93	0.00706	0.70494	134.018	0.48207	0.59261
Methylaspartate ammonia-lyase	0.02059	0.00344	0.02352	0.00198	0.00551	65	0.01854	0.00181	0.00441	93	0.00706	0.70494	134.018	0.48207	0.59261
Tryptophanase	0.02059	0.00344	0.02352	0.00198	0.00551	65	0.01854	0.00181	0.00441	93	0.00706	0.70494	134.018	0.48207	0.59261
Thymidylate synthase (FAD)	0.02007	0.00326	0.01881	0.00145	0.00472	65	0.02094	0.00186	0.00447	93	0.00650	-0.32792	147.729	0.74343	0.78693
L-arabinose isomerase	0.01894	0.00323	0.01780	0.00141	0.00466	65	0.01973	0.00183	0.00444	93	0.00643	-0.30075	148.045	0.76403	0.80245
L-ribulose-5-phosphate 4-epimerase	0.01894	0.00323	0.01780	0.00141	0.00466	65	0.01973	0.00183	0.00444	93	0.00643	-0.30075	148.045	0.76403	0.80245
Pectinesterase	0.01880	0.00326	0.01765	0.00148	0.00477	65	0.01961	0.00183	0.00443	93	0.00651	-0.30023	146.378	0.76443	0.80245
5-dehydro-4-deoxy-D-glucuronate isomerase	0.01848	0.00322	0.01688	0.00139	0.00462	65	0.01961	0.00183	0.00443	93	0.00640	-0.42642	148.552	0.67042	0.75392
Altronate dehydratase	0.01848	0.00322	0.01688	0.00139	0.00462	65	0.01961	0.00183	0.00443	93	0.00640	-0.42642	148.552	0.67042	0.75392
Tagaturonate reductase	0.01848	0.00322	0.01688	0.00139	0.00462	65	0.01961	0.00183	0.00443	93	0.00640	-0.42642	148.552	0.67042	0.75392
Chondroitin-sulfate-ABC endolyase	0.01817	0.00322	0.01610	0.00137	0.00460	65	0.01961	0.00183	0.00443	93	0.00639	-0.54890	148.868	0.58390	0.68024
Chondroitin-sulfate-ABC exolyase	0.01817	0.00322	0.01610	0.00137	0.00460	65	0.01961	0.00183	0.00443	93	0.00639	-0.54890	148.868	0.58390	0.68024
Fructuronate reductase	0.01817	0.00322	0.01610	0.00137	0.00460	65	0.01961	0.00183	0.00443	93	0.00639	-0.54890	148.868	0.58390	0.68024
Beta-fructofuranosidase	0.01721	0.00319	0.01456	0.00123	0.00435	65	0.01906	0.00187	0.00449	93	0.00625	-0.71857	152.532	0.47351	0.59072
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	0.01715	0.00341	0.01886	0.00198	0.00551	65	0.01595	0.00176	0.00435	93	0.00703	0.41410	132.799	0.67947	0.76048
Lysozyme	0.01644	0.00333	0.02180	0.00233	0.00598	65	0.01268	0.00134	0.00379	93	0.00708	1.28775	113.020	0.20046	0.32241
Leucyltransferase	0.01613	0.00335	0.01886	0.00198	0.00551	65	0.01423	0.00164	0.00421	93	0.00693	0.66794	129.605	0.50536	0.61472
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)	0.01603	0.00334	0.01820	0.00196	0.00549	65	0.01451	0.00164	0.00420	93	0.00692	0.53299	129.906	0.59495	0.69033
Nitric-oxide reductase (cytochrome c)	0.01582	0.00335	0.01809	0.00197	0.00550	65	0.01423	0.00164	0.00421	93	0.00692	0.55712	129.852	0.57841	0.67931
Dextranase	0.01406	0.00282	0.01373	0.00122	0.00433	65	0.01429	0.00129	0.00373	93	0.00572	-0.09911	140.345	0.92119	0.92599
Phosphatidylglycerophosphatase	0.01400	0.00308	0.01802	0.00197	0.00551	65	0.01119	0.00117	0.00355	93	0.00656	1.04229	114.441	0.29947	0.43241
Beta-lactamase	0.01383	0.00293	0.01589	0.00139	0.00462	65	0.01239	0.00134	0.00380	93	0.00598	0.58609	136.401	0.55878	0.66028
L-rhamnose isomerase	0.01317	0.00301	0.01192	0.00124	0.00436	65	0.01405	0.00158	0.00412	93	0.00600	-0.35474	147.413	0.72329	0.78152
Rhamnulokinase	0.01317	0.00301	0.01192	0.00124	0.00436	65	0.01405	0.00158	0.00412	93	0.00600	-0.35474	147.413	0.72329	0.78152
Rhamnulose-1-phosphate aldolase	0.01317	0.00301	0.01192	0.00124	0.00436	65	0.01405	0.00158	0.00412	93	0.00600	-0.35474	147.413	0.72329	0.78152
Maltose alpha-D-glucosyltransferase	0.01300	0.00300	0.01245	0.00135	0.00456	65	0.01338	0.00149	0.00400	93	0.00606	-0.15297	141.979	0.87864	0.90201
UDP-glucuronate 4-epimerase	0.01268	0.00273	0.01408	0.00106	0.00404	65	0.01170	0.00127	0.00370	93	0.00548	0.43564	145.391	0.66375	0.75392
Glycerol-3-phosphate cytidylyltransferase	0.01267	0.00300	0.01725	0.00196	0.00550	65	0.00947	0.00104	0.00334	93	0.00643	1.21009	109.604	0.22885	0.35908
4-carboxymuconolactone decarboxylase	0.01208	0.00270	0.01416	0.00106	0.00405	65	0.01063	0.00122	0.00362	93	0.00543	0.64950	143.609	0.51705	0.62597
Cyclic pyranopterin phosphate synthase	0.01176	0.00269	0.01338	0.00105	0.00401	65	0.01063	0.00122	0.00362	93	0.00541	0.50921	144.268	0.61138	0.70376
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0.01176	0.00269	0.01338	0.00105	0.00401	65	0.01063	0.00122	0.00362	93	0.00541	0.50921	144.268	0.61138	0.70376
UDP-glucuronate decarboxylase	0.01176	0.00269	0.01338	0.00105	0.00401	65	0.01063	0.00122	0.00362	93	0.00541	0.50921	144.268	0.61138	0.70376
Alpha-glucuronidase	0.01102	0.00265	0.00930	0.00084	0.00360	65	0.01222	0.00131	0.00375	93	0.00520	-0.56115	153.036	0.57552	0.67729
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming)	0.01070	0.00264	0.00852	0.00082	0.00354	65	0.01222	0.00131	0.00375	93	0.00516	-0.71542	153.657	0.47544	0.59072
Formyltetrahydrofolate deformylase	0.01070	0.00264	0.00852	0.00082	0.00354	65	0.01222	0.00131	0.00375	93	0.00516	-0.71542	153.657	0.47544	0.59072
Lipoate–protein ligase	0.01056	0.00274	0.00720	0.00078	0.00346	65	0.01291	0.00147	0.00397	93	0.00527	-1.08388	155.709	0.28010	0.41477
(R)-2-methylmalate dehydratase	0.00684	0.00324	0.00820	0.00203	0.00559	65	0.00590	0.00142	0.00391	93	0.00682	0.33663	121.543	0.73697	0.78152
3-isopropylmalate dehydratase	0.00684	0.00324	0.00820	0.00203	0.00559	65	0.00590	0.00142	0.00391	93	0.00682	0.33663	121.543	0.73697	0.78152
Lactoylglutathione lyase	0.00647	0.00219	0.00387	0.00033	0.00225	65	0.00829	0.00105	0.00336	93	0.00405	-1.08932	149.749	0.27776	0.41237
Sulfate adenylyltransferase	0.00623	0.00290	0.00586	0.00121	0.00432	65	0.00649	0.00143	0.00391	93	0.00583	-0.10880	144.556	0.91351	0.91987
L-threonine aldolase	0.00545	0.00176	0.00700	0.00062	0.00310	65	0.00436	0.00040	0.00208	93	0.00373	0.70639	117.912	0.48134	0.59261
Gingipain R	0.00539	0.00208	0.00781	0.00107	0.00405	65	0.00370	0.00042	0.00212	93	0.00457	0.89934	98.630	0.37066	0.49111
L-rhamnose mutarotase	0.00527	0.00208	0.00555	0.00073	0.00336	65	0.00508	0.00066	0.00266	93	0.00428	0.11022	132.912	0.91240	0.91987
Aconitate hydratase	0.00356	0.00185	0.00590	0.00087	0.00366	65	0.00191	0.00031	0.00183	93	0.00410	0.97374	95.817	0.33264	0.44583
Isocitrate dehydrogenase (NADP(+))	0.00356	0.00185	0.00590	0.00087	0.00366	65	0.00191	0.00031	0.00183	93	0.00410	0.97374	95.817	0.33264	0.44583
Polar-amino-acid-transporting ATPase	0.00347	0.00166	0.00161	0.00007	0.00104	65	0.00476	0.00069	0.00273	93	0.00292	-1.07874	117.046	0.28292	0.41481
(R)-citramalate synthase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
2-isopropylmalate synthase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
3-isopropylmalate dehydrogenase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Acetylglutamate kinase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Acetylornithine deacetylase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Acetylornithine transaminase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Argininosuccinate lyase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Argininosuccinate synthase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
ATP phosphoribosyltransferase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Histidinol-phosphatase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Histidinol dehydrogenase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Imidazoleglycerol-phosphate dehydratase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
isomerase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
N-acetyl-gamma-glutamyl-phosphate reductase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
N-succinylornithine carbamoyltransferase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Phosphoribosyl-AMP cyclohydrolase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Phosphoribosyl-ATP diphosphatase	0.00342	0.00162	0.00410	0.00051	0.00280	65	0.00295	0.00035	0.00195	93	0.00341	0.33663	121.543	0.73697	0.78152
Anthranilate phosphoribosyltransferase	0.00339	0.00162	0.00410	0.00051	0.00280	65	0.00290	0.00036	0.00195	93	0.00341	0.35080	121.551	0.72634	0.78152
Potassium-transporting ATPase	0.00316	0.00310	0.00752	0.00368	0.00752	65	0.00010	0.00000	0.00010	93	0.00752	0.98624	64.024	0.32773	0.44129
Creatininase	0.00315	0.00164	0.00084	0.00003	0.00071	65	0.00476	0.00069	0.00273	93	0.00282	-1.39249	104.041	0.16674	0.28014
Exo-1,4-beta-D-glucosaminidase	0.00315	0.00164	0.00084	0.00003	0.00071	65	0.00476	0.00069	0.00273	93	0.00282	-1.39249	104.041	0.16674	0.28014
N-acetylneuraminate synthase	0.00315	0.00164	0.00084	0.00003	0.00071	65	0.00476	0.00069	0.00273	93	0.00282	-1.39249	104.041	0.16674	0.28014
N-acylneuraminate cytidylyltransferase	0.00315	0.00164	0.00084	0.00003	0.00071	65	0.00476	0.00069	0.00273	93	0.00282	-1.39249	104.041	0.16674	0.28014
RNA ligase (ATP)	0.00315	0.00164	0.00084	0.00003	0.00071	65	0.00476	0.00069	0.00273	93	0.00282	-1.39249	104.041	0.16674	0.28014
4-phosphoerythronate dehydrogenase	0.00311	0.00145	0.00293	0.00030	0.00216	65	0.00324	0.00036	0.00196	93	0.00291	-0.10880	144.556	0.91351	0.91987
8-amino-7-oxononanoate synthase	0.00311	0.00145	0.00293	0.00030	0.00216	65	0.00324	0.00036	0.00196	93	0.00291	-0.10880	144.556	0.91351	0.91987
Adenylyl-sulfate kinase	0.00311	0.00145	0.00293	0.00030	0.00216	65	0.00324	0.00036	0.00196	93	0.00291	-0.10880	144.556	0.91351	0.91987
AMP nucleosidase	0.00311	0.00145	0.00293	0.00030	0.00216	65	0.00324	0.00036	0.00196	93	0.00291	-0.10880	144.556	0.91351	0.91987
Exodeoxyribonuclease V	0.00311	0.00145	0.00293	0.00030	0.00216	65	0.00324	0.00036	0.00196	93	0.00291	-0.10880	144.556	0.91351	0.91987
Nucleoside-diphosphate kinase	0.00311	0.00145	0.00293	0.00030	0.00216	65	0.00324	0.00036	0.00196	93	0.00291	-0.10880	144.556	0.91351	0.91987
Polynucleotide adenylyltransferase	0.00311	0.00145	0.00293	0.00030	0.00216	65	0.00324	0.00036	0.00196	93	0.00291	-0.10880	144.556	0.91351	0.91987
Pyridoxine 5’-phosphate synthase	0.00311	0.00145	0.00293	0.00030	0.00216	65	0.00324	0.00036	0.00196	93	0.00291	-0.10880	144.556	0.91351	0.91987
Xylose isomerase	0.00307	0.00159	0.00332	0.00047	0.00270	65	0.00290	0.00036	0.00195	93	0.00333	0.12651	124.682	0.89953	0.91987
CDP-glycerol glycerophosphotransferase	0.00230	0.00133	0.00393	0.00050	0.00276	65	0.00116	0.00013	0.00116	93	0.00300	0.92313	86.745	0.35850	0.47828
Hippurate hydrolase	0.00207	0.00126	0.00251	0.00041	0.00251	65	0.00176	0.00014	0.00125	93	0.00280	0.26828	95.453	0.78906	0.82616
Pyrroline-5-carboxylate reductase	0.00171	0.00071	0.00244	0.00012	0.00137	65	0.00120	0.00005	0.00073	93	0.00155	0.80158	99.840	0.42470	0.54767
Alpha-L-rhamnosidase	0.00158	0.00065	0.00193	0.00009	0.00116	65	0.00134	0.00005	0.00075	93	0.00138	0.43390	114.502	0.66517	0.75392
Nitrous-oxide reductase	0.00158	0.00065	0.00193	0.00009	0.00116	65	0.00134	0.00005	0.00075	93	0.00138	0.43390	114.502	0.66517	0.75392
Type III site-specific deoxyribonuclease	0.00133	0.00080	0.00078	0.00004	0.00078	65	0.00172	0.00014	0.00125	93	0.00147	-0.64553	145.619	0.51960	0.62676
Cellobiose phosphorylase	0.00124	0.00060	0.00148	0.00007	0.00104	65	0.00107	0.00005	0.00071	93	0.00126	0.32436	119.723	0.74623	0.78844
Citrate CoA-transferase	0.00105	0.00103	0.00251	0.00041	0.00251	65	0.00003	0.00000	0.00003	93	0.00251	0.98624	64.024	0.32773	0.44129
Citrate lyase holo-[acyl-carrier protein] synthase	0.00105	0.00103	0.00251	0.00041	0.00251	65	0.00003	0.00000	0.00003	93	0.00251	0.98624	64.024	0.32773	0.44129
Citryl-CoA lyase	0.00105	0.00103	0.00251	0.00041	0.00251	65	0.00003	0.00000	0.00003	93	0.00251	0.98624	64.024	0.32773	0.44129
RNA-directed DNA polymerase	0.00105	0.00103	0.00251	0.00041	0.00251	65	0.00003	0.00000	0.00003	93	0.00251	0.98624	64.024	0.32773	0.44129
Glucosylceramidase	0.00092	0.00051	0.00070	0.00003	0.00070	65	0.00107	0.00005	0.00071	93	0.00100	-0.36761	151.566	0.71368	0.78152
2-iminoacetate synthase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Asparagine synthase (glutamine-hydrolyzing)	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Aspartyl aminopeptidase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Cellulase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Citrate (Si)-synthase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
D-glycero-alpha-D-manno-heptose-7-phosphate kinase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
D-sedoheptulose 7-phosphate isomerase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Endo-1,4-beta-xylanase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Glutamate-5-semialdehyde dehydrogenase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Glutamate 5-kinase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Phosphoadenylyl-sulfate reductase (thioredoxin)	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Prolyl aminopeptidase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845
Thiazole synthase	0.00032	0.00032	0.00078	0.00004	0.00078	65	0.00000	0.00000	0.00000	93	0.00078	1.00000	64.000	0.32108	0.43845

plot.dat <- tb.ra %>%
  arrange(desc(`Overall Mean`)) %>%
  slice_head(n=50) %>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    diff_se = SEpooled,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*diff_se,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*diff_se
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.05))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.10,y = 25,
             angle=90,
             label="q-value (FDR Corrected p-value)")+
    labs(x="Mean Difference in RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p <- p1 + p2 +
  plot_annotation(title="Stratefied EC Data - Prevotella spp. (genus level only): 50 most abundant descriptions")
p

ggsave("output/updated-figures-2021-05-20/picrust-prevo-EC.pdf",p,units="in", height=12, width=10)

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

    0     1 
38726 52756 

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
 -7.50   -6.68   -4.88    1.25   29.69  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)    
(Intercept)    3.336      0.177   18.85   <2e-16 ***
tumor         -0.230      0.296   -0.78     0.44    
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 81.936)

    Null deviance: 8507.2  on 157  degrees of freedom
Residual deviance: 8456.6  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 6

Run over all descriptors

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")

description	Est	SE	p	fdr_p
(2E,6E)-farnesyl diphosphate synthase	-0.230	0.296	0.438	0.635
(4S)-4-hydroxy-2-oxoglutarate aldolase	-0.628	0.582	0.282	0.635
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)	-0.230	0.296	0.438	0.635
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)	-0.230	0.296	0.438	0.635
(Kdo)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase	-0.230	0.296	0.438	0.635
(Kdo)(2)-lipid IV(A) (2-8) 3-deoxy-D-manno-octulosonic acid transferase	-0.230	0.296	0.438	0.635
(Kdo)(3)-lipid IV(A) (2-4) 3-deoxy-D-manno-octulosonic acid transferase	-0.230	0.296	0.438	0.635
(R)-2-methylmalate dehydratase	-0.100	1.127	0.930	0.968
(R)-citramalate synthase	-0.100	1.127	0.930	0.968
[Acyl-carrier-protein] S-malonyltransferase	-0.230	0.296	0.438	0.635
[Formate-C-acetyltransferase]-activating enzyme	-0.204	0.299	0.496	0.635
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase	-0.230	0.296	0.438	0.635
1-acylglycerol-3-phosphate O-acyltransferase	-0.230	0.296	0.438	0.635
1-deoxy-D-xylulose-5-phosphate reductoisomerase	-0.230	0.296	0.438	0.635
1-deoxy-D-xylulose-5-phosphate synthase	-0.211	0.305	0.489	0.635
1,4-alpha-glucan branching enzyme	-0.230	0.296	0.438	0.635
1,4-beta-mannosyl-N-acetylglucosamine phosphorylase	-0.234	0.288	0.419	0.635
1,4-dihydroxy-2-naphthoate polyprenyltransferase	-0.230	0.296	0.438	0.635
1,4-dihydroxy-2-naphthoyl-CoA synthase	-0.230	0.296	0.438	0.635
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase	-0.230	0.296	0.438	0.635
16S rRNA (cytidine(1402)-2’-O)-methyltransferase	-0.242	0.294	0.412	0.635
16S rRNA (cytosine(1402)-N(4))-methyltransferase	-0.230	0.296	0.438	0.635
16S rRNA (guanine(527)-N(7))-methyltransferase	-0.230	0.296	0.438	0.635
16S rRNA (uracil(1498)-N(3))-methyltransferase	-0.230	0.296	0.438	0.635
2’,3’-cyclic-nucleotide 2’-phosphodiesterase	-0.285	0.310	0.360	0.635
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	-0.240	0.304	0.431	0.635
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-0.230	0.296	0.438	0.635
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-0.232	0.307	0.452	0.635
2-dehydro-3-deoxy-phosphogluconate aldolase	-0.628	0.582	0.282	0.635
2-dehydro-3-deoxygluconokinase	-0.577	0.590	0.329	0.635
2-dehydropantoate 2-reductase	-0.220	0.329	0.504	0.635
2-iminoacetate synthase	18.519	3411.091	0.996	0.997
2-iminobutanoate/2-iminopropanoate deaminase	-0.230	0.296	0.438	0.635
2-isopropylmalate synthase	-0.100	1.127	0.930	0.968
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase	-0.230	0.296	0.438	0.635
2-oxoacid oxidoreductase (ferredoxin)	-0.241	0.306	0.433	0.635
2-oxoglutarate synthase	-0.237	0.303	0.434	0.635
23S rRNA (adenine(2085)-N(6))-dimethyltransferase	0.141	0.367	0.701	0.790
23S rRNA (adenine(2503)-C(2))-methyltransferase	-0.230	0.296	0.438	0.635
23S rRNA (cytosine(1962)-C(5))-methyltransferase	-0.230	0.296	0.438	0.635
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase	-0.230	0.296	0.438	0.635
23S rRNA (uracil(1939)-C(5))-methyltransferase	-0.230	0.296	0.438	0.635
23S rRNA pseudouridine(1911/1915/1917) synthase	-0.230	0.296	0.438	0.635
23S rRNA pseudouridine(2605) synthase	-0.230	0.296	0.438	0.635
23S rRNA pseudouridine(746) synthase	-0.223	0.336	0.508	0.635
3’-nucleotidase	-0.285	0.310	0.360	0.635
3’(2’),5’-bisphosphate nucleotidase	-0.242	0.294	0.412	0.635
3-dehydroquinate dehydratase	-0.230	0.296	0.438	0.635
3-dehydroquinate synthase	-0.230	0.296	0.438	0.635
3-deoxy-8-phosphooctulonate synthase	-0.230	0.296	0.438	0.635
3-deoxy-manno-octulosonate-8-phosphatase	-0.232	0.301	0.441	0.635
3-deoxy-manno-octulosonate cytidylyltransferase	-0.243	0.292	0.407	0.635
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	-0.331	0.309	0.285	0.635
3-isopropylmalate dehydratase	-0.100	1.127	0.930	0.968
3-isopropylmalate dehydrogenase	-0.100	1.127	0.930	0.968
3-methyl-2-oxobutanoate hydroxymethyltransferase	-0.213	0.298	0.477	0.635
3-oxoacyl-[acyl-carrier-protein] reductase	-0.342	0.306	0.265	0.635
3-phosphoshikimate 1-carboxyvinyltransferase	-0.230	0.296	0.438	0.635
3,4-dihydroxy-2-butanone-4-phosphate synthase	-0.226	0.295	0.445	0.635
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase	-0.230	0.296	0.438	0.635
4-alpha-glucanotransferase	-0.230	0.296	0.438	0.635
4-carboxymuconolactone decarboxylase	-0.135	0.612	0.825	0.905
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-0.230	0.296	0.438	0.635
4-hydroxy-tetrahydrodipicolinate reductase	-0.230	0.296	0.438	0.635
4-hydroxy-tetrahydrodipicolinate synthase	-0.230	0.296	0.438	0.635
4-hydroxythreonine-4-phosphate dehydrogenase	-0.230	0.296	0.438	0.635
4-O-beta-D-mannosyl-D-glucose phosphorylase	-0.588	0.587	0.318	0.635
4-phosphoerythronate dehydrogenase	-0.754	1.120	0.502	0.635
5’-nucleotidase	-0.225	0.298	0.452	0.635
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming)	-0.789	0.881	0.372	0.635
5-(carboxyamino)imidazole ribonucleotide mutase	-0.230	0.296	0.438	0.635
5-amino-6-(5-phosphoribosylamino)uracil reductase	-0.230	0.296	0.438	0.635
5-dehydro-4-deoxy-D-glucuronate isomerase	-0.676	0.652	0.302	0.635
5-formyltetrahydrofolate cyclo-ligase	-0.230	0.296	0.438	0.635
6-carboxytetrahydropterin synthase	-0.395	0.451	0.383	0.635
6-phosphofructokinase	-0.230	0.296	0.438	0.635
6-pyruvoyltetrahydropterin synthase	-0.395	0.451	0.383	0.635
6,7-dimethyl-8-ribityllumazine synthase	-0.230	0.296	0.438	0.635
7-cyano-7-deazaguanine synthase	-0.230	0.296	0.438	0.635
8-amino-7-oxononanoate synthase	-0.754	1.120	0.502	0.635
8-oxo-dGTP diphosphatase	-0.128	0.324	0.693	0.790
Acetate–CoA ligase	-0.203	0.301	0.500	0.635
Acetate kinase	-0.230	0.296	0.438	0.635
Acetolactate synthase	-0.548	0.584	0.350	0.635
acetylglucosaminyltransferase	-0.230	0.296	0.438	0.635
Acetylglutamate kinase	-0.100	1.127	0.930	0.968
Acetylornithine deacetylase	-0.100	1.127	0.930	0.968
Acetylornithine transaminase	-0.100	1.127	0.930	0.968
Acid phosphatase	-0.073	0.305	0.811	0.902
Aconitate hydratase	-0.429	1.387	0.758	0.845
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase	-0.230	0.296	0.438	0.635
Adenine phosphoribosyltransferase	-0.230	0.296	0.438	0.635
Adenosylcobalamin/alpha-ribazole phosphatase	-0.680	0.538	0.208	0.635
Adenosylcobinamide-GDP ribazoletransferase	-0.680	0.538	0.208	0.635
Adenosylcobinamide-phosphate guanylyltransferase	-0.680	0.538	0.208	0.635
Adenosylcobinamide kinase	-0.680	0.538	0.208	0.635
Adenosylhomocysteine nucleosidase	-0.230	0.296	0.438	0.635
Adenylate kinase	-0.230	0.296	0.438	0.635
Adenylosuccinate lyase	-0.230	0.296	0.438	0.635
Adenylosuccinate synthase	-0.230	0.296	0.438	0.635
Adenylyl-sulfate kinase	-0.754	1.120	0.502	0.635
Alanine–tRNA ligase	-0.230	0.296	0.438	0.635
Alanine dehydrogenase	-0.647	0.554	0.244	0.635
Alanine racemase	-0.230	0.296	0.438	0.635
Aldose 1-epimerase	-0.243	0.306	0.429	0.635
Alkaline phosphatase	-0.400	0.466	0.392	0.635
All-trans-octaprenyl-diphosphate synthase	-0.230	0.296	0.438	0.635
All-trans-retinol 13,14-reductase	-0.696	0.523	0.185	0.635
Alpha-amylase	-0.248	0.296	0.404	0.635
Alpha-D-xyloside xylohydrolase	-0.603	0.561	0.284	0.635
Alpha-galactosidase	-0.168	0.287	0.561	0.685
Alpha-glucosidase	-0.117	0.305	0.702	0.790
Alpha-glucuronidase	-0.788	0.881	0.373	0.635
Alpha-L-fucosidase	-0.244	0.296	0.412	0.635
Alpha-L-rhamnosidase	-0.319	0.983	0.746	0.837
Alpha-N-acetylglucosaminidase	-0.855	0.801	0.287	0.635
Altronate dehydratase	-0.676	0.652	0.302	0.635
Amidophosphoribosyltransferase	-0.219	0.308	0.477	0.635
Aminoacyl-tRNA hydrolase	-0.230	0.296	0.438	0.635
Aminodeoxychorismate lyase	-0.158	0.328	0.632	0.736
Aminodeoxychorismate synthase	-0.158	0.328	0.632	0.736
Aminomethyltransferase	-0.190	0.321	0.556	0.680
AMP nucleosidase	-0.754	1.120	0.502	0.635
Anthranilate phosphoribosyltransferase	-0.089	1.133	0.938	0.969
Anthranilate synthase	-0.163	0.338	0.630	0.736
Arabinan endo-1,5-alpha-L-arabinosidase	-0.573	0.507	0.260	0.635
Arabinogalactan endo-beta-1,4-galactanase	-0.483	0.529	0.363	0.635
Arabinose-5-phosphate isomerase	-0.230	0.296	0.438	0.635
Arginine–tRNA ligase	-0.230	0.296	0.438	0.635
Arginine decarboxylase	-0.230	0.296	0.438	0.635
Argininosuccinate lyase	-0.100	1.127	0.930	0.968
Argininosuccinate synthase	-0.100	1.127	0.930	0.968
Arylsulfatase	-0.131	0.339	0.701	0.790
Asparaginase	-0.260	0.336	0.441	0.635
Asparagine–tRNA ligase	-0.230	0.296	0.438	0.635
Asparagine synthase (glutamine-hydrolyzing)	18.519	3411.091	0.996	0.997
Aspartate–ammonia ligase	-0.213	0.293	0.468	0.635
Aspartate–tRNA ligase	-0.230	0.296	0.438	0.635
Aspartate-semialdehyde dehydrogenase	-0.230	0.296	0.438	0.635
Aspartate 1-decarboxylase	-0.213	0.298	0.477	0.635
Aspartate ammonia-lyase	-0.259	0.322	0.423	0.635
Aspartate carbamoyltransferase	-0.230	0.296	0.438	0.635
Aspartate kinase	-0.249	0.296	0.402	0.635
Aspartate transaminase	-0.235	0.289	0.416	0.635
Aspartyl aminopeptidase	18.519	3411.091	0.996	0.997
ATP phosphoribosyltransferase	-0.100	1.127	0.930	0.968
Bacterial non-heme ferritin	-0.219	0.301	0.468	0.635
Beta-1,4-mannooligosaccharide phosphorylase	-0.234	0.288	0.419	0.635
Beta-fructofuranosidase	-0.496	0.487	0.311	0.635
Beta-galactosidase	-0.246	0.296	0.408	0.635
Beta-glucosidase	-0.399	0.427	0.352	0.635
Beta-ketoacyl-[acyl-carrier-protein] synthase I	-0.741	0.488	0.131	0.635
Beta-ketoacyl-[acyl-carrier-protein] synthase II	-0.230	0.296	0.438	0.635
Beta-ketoacyl-[acyl-carrier-protein] synthase III	-0.223	0.335	0.506	0.635
Beta-lactamase	-0.298	0.574	0.604	0.718
Beta-N-acetylhexosaminidase	-0.212	0.270	0.432	0.635
Biotin–[acetyl-CoA-carboxylase] ligase	-0.230	0.296	0.438	0.635
Bleomycin hydrolase	-0.224	0.296	0.452	0.635
Branched-chain-amino-acid transaminase	-0.230	0.296	0.438	0.635
Butyrate kinase	-0.147	0.329	0.655	0.755
C-terminal processing peptidase	-0.230	0.296	0.438	0.635
Cadmium-exporting ATPase	-0.201	0.284	0.481	0.635
Calcium-transporting ATPase	-0.156	0.300	0.605	0.718
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	-0.232	0.298	0.439	0.635
Carbonate dehydratase	-0.169	0.333	0.614	0.727
Carboxynorspermidine decarboxylase	-0.230	0.296	0.438	0.635
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	-0.227	0.517	0.662	0.761
CDP-diacylglycerol–serine O-phosphatidyltransferase	-0.230	0.296	0.438	0.635
CDP-glycerol glycerophosphotransferase	0.092	1.404	0.948	0.979
Cellobiose phosphorylase	0.154	1.349	0.909	0.968
Cellulase	18.519	3411.091	0.996	0.997
Choline-phosphate cytidylyltransferase	-0.221	0.572	0.699	0.790
Chondroitin-sulfate-ABC endolyase	-0.677	0.652	0.301	0.635
Chondroitin-sulfate-ABC exolyase	-0.677	0.652	0.301	0.635
Chorismate mutase	-0.230	0.296	0.438	0.635
Chorismate synthase	-0.230	0.296	0.438	0.635
Citrate (Si)-synthase	18.519	3411.091	0.996	0.997
Citrate CoA-transferase	2.304	1.989	0.248	0.635
Citrate lyase holo-[acyl-carrier protein] synthase	2.304	1.989	0.248	0.635
Citryl-CoA lyase	2.304	1.989	0.248	0.635
Cob(I)yrinic acid a,c-diamide adenosyltransferase	-0.256	0.335	0.446	0.635
Cobaltochelatase	-0.341	0.419	0.416	0.635
Coproporphyrinogen dehydrogenase	-0.227	0.294	0.441	0.635
Creatininase	-2.232	1.933	0.250	0.635
Crossover junction endodeoxyribonuclease	-0.230	0.296	0.438	0.635
CTP synthase (glutamine hydrolyzing)	-0.230	0.296	0.438	0.635
Cu(2+)-exporting ATPase	-0.224	0.285	0.434	0.635
Cyclic pyranopterin phosphate synthase	-0.137	0.613	0.823	0.905
Cystathionine beta-lyase	-0.267	0.319	0.403	0.635
Cysteine–tRNA ligase	-0.230	0.296	0.438	0.635
Cysteine desulfurase	-0.230	0.296	0.438	0.635
Cysteine synthase	-0.260	0.313	0.407	0.635
Cytidine deaminase	-0.230	0.296	0.438	0.635
D-Ala-D-Ala dipeptidase	-0.199	0.288	0.490	0.635
D-alanine–D-alanine ligase	-0.230	0.296	0.438	0.635
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase	18.519	3411.091	0.996	0.997
D-glycero-alpha-D-manno-heptose-7-phosphate kinase	18.519	3411.091	0.996	0.997
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	18.519	3411.091	0.996	0.997
D-lactate dehydrogenase	-0.088	0.288	0.760	0.846
D-sedoheptulose 7-phosphate isomerase	18.519	3411.091	0.996	0.997
dCMP deaminase	-0.230	0.296	0.438	0.635
Demethylmenaquinone methyltransferase	-0.230	0.296	0.438	0.635
Deoxyribose-phosphate aldolase	-0.230	0.296	0.438	0.635
Dephospho-CoA kinase	-0.228	0.308	0.459	0.635
Dextranase	-0.282	0.509	0.580	0.704
dGTPase	-0.230	0.296	0.438	0.635
Diamine N-acetyltransferase	-0.230	0.296	0.438	0.635
Diaminohydroxyphosphoribosylaminopyrimidine deaminase	-0.230	0.296	0.438	0.635
Diaminopimelate decarboxylase	-0.274	0.307	0.374	0.635
Diaminopimelate dehydrogenase	-0.228	0.293	0.436	0.635
Diaminopimelate epimerase	-0.394	0.395	0.320	0.635
Dihydrofolate reductase	-0.201	0.284	0.481	0.635
Dihydrofolate synthase	-0.230	0.296	0.438	0.635
Dihydrolipoyl dehydrogenase	-0.190	0.321	0.556	0.680
Dihydroneopterin aldolase	-0.230	0.296	0.438	0.635
Dihydroorotase	-0.220	0.308	0.477	0.635
Dihydroorotate dehydrogenase (NAD(+))	-0.230	0.296	0.438	0.635
Dihydropteroate synthase	-0.230	0.296	0.438	0.635
Dihydroxy-acid dehydratase	-0.548	0.584	0.350	0.635
Dimethylallyltranstransferase	-0.230	0.296	0.438	0.635
Dipeptidase E	-0.619	0.514	0.230	0.635
Dipeptidyl-peptidase III	-0.230	0.296	0.438	0.635
Dipeptidyl-peptidase IV	-0.230	0.296	0.438	0.635
Diphosphate–fructose-6-phosphate 1-phosphotransferase	-0.230	0.296	0.438	0.635
diphosphate specific)	-0.230	0.296	0.438	0.635
DNA-(apurinic or apyrimidinic site) lyase	-0.138	0.295	0.642	0.745
DNA-3-methyladenine glycosylase I	-0.227	0.333	0.497	0.635
DNA-directed DNA polymerase	-0.228	0.295	0.441	0.635
DNA-directed RNA polymerase	-0.227	0.300	0.450	0.635
DNA (cytosine-5-)-methyltransferase	-0.244	0.306	0.427	0.635
DNA helicase	-0.238	0.300	0.428	0.635
DNA ligase (NAD(+))	-0.230	0.296	0.438	0.635
DNA topoisomerase	-0.294	0.331	0.376	0.635
DNA topoisomerase (ATP-hydrolyzing)	-0.230	0.296	0.438	0.635
Dolichyl-phosphate beta-D-mannosyltransferase	-0.230	0.296	0.438	0.635
dTDP-4-dehydrorhamnose 3,5-epimerase	-0.230	0.296	0.438	0.635
dTDP-4-dehydrorhamnose reductase	-0.230	0.296	0.438	0.635
dTDP-glucose 4,6-dehydratase	-0.230	0.296	0.438	0.635
dUTP diphosphatase	-0.230	0.296	0.438	0.635
Endo-1,4-beta-xylanase	18.519	3411.091	0.996	0.997
Endopeptidase Clp	-0.230	0.296	0.438	0.635
Endopeptidase La	-0.220	0.308	0.477	0.635
Enoyl-[acyl-carrier-protein] reductase (NADH)	-0.219	0.301	0.468	0.635
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)	-0.219	0.301	0.468	0.635
Epoxyqueuosine reductase	-0.230	0.296	0.438	0.635
Exo-1,4-beta-D-glucosaminidase	-2.232	1.933	0.250	0.635
Exo-alpha-sialidase	-0.234	0.288	0.419	0.635
Exodeoxyribonuclease III	-0.138	0.295	0.642	0.745
Exodeoxyribonuclease V	-0.754	1.120	0.502	0.635
Exodeoxyribonuclease VII	-0.230	0.296	0.438	0.635
FAD synthetase	-0.230	0.296	0.438	0.635
FMN reductase (NAD(P)H)	-0.230	0.296	0.438	0.635
Formate–tetrahydrofolate ligase	-0.263	0.312	0.401	0.635
Formate C-acetyltransferase	-0.215	0.295	0.468	0.635
Formimidoyltetrahydrofolate cyclodeaminase	-0.162	0.333	0.626	0.734
Formyltetrahydrofolate deformylase	-0.789	0.881	0.372	0.635
Fructan beta-fructosidase	-0.268	0.313	0.394	0.635
Fructokinase	-0.239	0.302	0.431	0.635
Fructose-bisphosphatase	-0.230	0.296	0.438	0.635
Fructose-bisphosphate aldolase	-0.230	0.296	0.438	0.635
Fructuronate reductase	-0.677	0.652	0.301	0.635
Fumarate hydratase	-0.228	0.345	0.510	0.635
Fumarate reductase (quinol)	-0.230	0.296	0.438	0.635
Galactokinase	-0.224	0.269	0.406	0.635
Galactoside O-acetyltransferase	-0.062	0.367	0.865	0.945
GDP-L-fucose synthase	-0.230	0.296	0.438	0.635
GDP-mannose 4,6-dehydratase	-0.230	0.296	0.438	0.635
Geranylgeranyl diphosphate synthase	-0.230	0.296	0.438	0.635
Gingipain R	-0.001	1.049	0.999	0.999
Glucokinase	-0.268	0.292	0.361	0.635
Gluconate 5-dehydrogenase	-0.542	0.584	0.355	0.635
Glucosamine-6-phosphate deaminase	-0.226	0.290	0.438	0.635
Glucose-1-phosphatase	-0.072	0.305	0.815	0.904
Glucose-1-phosphate thymidylyltransferase	-0.230	0.296	0.438	0.635
Glucose-6-phosphate isomerase	-0.230	0.296	0.438	0.635
Glucosylceramidase	0.151	1.352	0.911	0.968
Glucuronate isomerase	-0.839	0.582	0.151	0.635
Glutamate–ammonia ligase	-0.204	0.294	0.489	0.635
Glutamate–tRNA ligase	-0.230	0.296	0.438	0.635
Glutamate-5-semialdehyde dehydrogenase	18.519	3411.091	0.996	0.997
Glutamate 5-kinase	18.519	3411.091	0.996	0.997
Glutamate dehydrogenase (NADP(+))	-0.154	0.290	0.596	0.718
Glutamate formimidoyltransferase	-0.162	0.333	0.626	0.734
Glutamate racemase	-0.230	0.296	0.438	0.635
Glutamate synthase (NADH)	-0.323	0.318	0.311	0.635
Glutamate synthase (NADPH)	-0.323	0.318	0.311	0.635
Glutamine–fructose-6-phosphate transaminase (isomerizing)	-0.243	0.311	0.436	0.635
Glutamine–tRNA ligase	-0.230	0.296	0.438	0.635
Glutathione peroxidase	-0.203	0.301	0.502	0.635
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	-0.230	0.296	0.438	0.635
Glycerate 3-kinase	-0.206	0.323	0.524	0.647
Glycerate dehydrogenase	-0.230	0.296	0.438	0.635
Glycerol-3-phosphate cytidylyltransferase	0.358	0.550	0.516	0.641
Glycerol-3-phosphate dehydrogenase	-0.228	0.331	0.492	0.635
Glycerol-3-phosphate dehydrogenase (NAD(P)(+))	-0.230	0.296	0.438	0.635
Glycerol kinase	-0.075	0.341	0.826	0.905
Glycerophosphodiester phosphodiesterase	-0.647	0.496	0.194	0.635
Glycine–tRNA ligase	-0.230	0.296	0.438	0.635
Glycine C-acetyltransferase	-0.323	0.372	0.387	0.635
Glycine dehydrogenase (aminomethyl-transferring)	-0.190	0.321	0.556	0.680
Glycine hydroxymethyltransferase	-0.230	0.296	0.438	0.635
Glycogen phosphorylase	-0.230	0.296	0.438	0.635
GMP synthase (glutamine-hydrolyzing)	-0.230	0.296	0.438	0.635
GTP cyclohydrolase I	-0.201	0.284	0.481	0.635
GTP cyclohydrolase II	-0.231	0.296	0.437	0.635
GTP diphosphokinase	-0.231	0.299	0.439	0.635
Guanylate kinase	-0.230	0.296	0.438	0.635
H(+)-transporting two-sector ATPase	-0.237	0.295	0.423	0.635
Hippurate hydrolase	-1.546	2.070	0.456	0.635
Histidine–tRNA ligase	-0.230	0.296	0.438	0.635
Histidine ammonia-lyase	-0.162	0.333	0.626	0.734
Histidine kinase	-0.226	0.296	0.445	0.635
Histidinol-phosphatase	-0.100	1.127	0.930	0.968
Histidinol-phosphate transaminase	-0.159	0.284	0.576	0.702
Histidinol dehydrogenase	-0.100	1.127	0.930	0.968
Homoserine dehydrogenase	-0.274	0.307	0.374	0.635
Homoserine O-succinyltransferase	-0.274	0.307	0.374	0.635
Hyaluronoglucosaminidase	-0.247	0.317	0.437	0.635
Hydroxylamine reductase	-0.206	0.301	0.494	0.635
Hydroxymethylpyrimidine kinase	-0.134	0.312	0.669	0.765
Hypoxanthine phosphoribosyltransferase	-0.230	0.296	0.438	0.635
Imidazoleglycerol-phosphate dehydratase	-0.100	1.127	0.930	0.968
Imidazolonepropionase	-0.162	0.333	0.626	0.734
IMP cyclohydrolase	-0.230	0.296	0.438	0.635
IMP dehydrogenase	-0.230	0.296	0.438	0.635
Indole-3-glycerol-phosphate synthase	-0.376	0.442	0.397	0.635
Inorganic diphosphatase	-0.240	0.317	0.450	0.635
Inositol-3-phosphate synthase	-0.144	0.334	0.667	0.765
Iron-chelate-transporting ATPase	-0.230	0.296	0.438	0.635
Isochorismate synthase	-0.230	0.296	0.438	0.635
Isocitrate dehydrogenase (NADP(+))	-0.429	1.387	0.758	0.845
Isoleucine–tRNA ligase	-0.220	0.308	0.477	0.635
isomerase	-0.100	1.127	0.930	0.968
Kdo(2)-lipid IV(A) lauroyltransferase	-0.230	0.296	0.438	0.635
Ketol-acid reductoisomerase (NADP(+))	-0.548	0.584	0.350	0.635
L-arabinose isomerase	-0.670	0.642	0.298	0.635
L-aspartate oxidase	-0.172	0.328	0.602	0.718
L-rhamnose isomerase	-0.810	0.830	0.330	0.635
L-rhamnose mutarotase	-0.846	0.965	0.382	0.635
L-ribulose-5-phosphate 4-epimerase	-0.670	0.642	0.298	0.635
L-serine ammonia-lyase	-0.230	0.296	0.438	0.635
L-threonine aldolase	-0.170	0.761	0.824	0.905
L-threonylcarbamoyladenylate synthase	-0.230	0.296	0.438	0.635
Lactoylglutathione lyase	-1.045	0.919	0.257	0.635
Leucine–tRNA ligase	-0.222	0.299	0.458	0.635
Leucyltransferase	0.056	0.493	0.910	0.968
Levanase	-0.223	0.321	0.489	0.635
Lipid-A-disaccharide synthase	-0.230	0.296	0.438	0.635
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase	-0.230	0.296	0.438	0.635
Lipoate–protein ligase	-0.717	0.722	0.322	0.635
Lipoyl synthase	-0.230	0.317	0.469	0.635
LL-diaminopimelate aminotransferase	-0.394	0.395	0.320	0.635
Long-chain-fatty-acid–CoA ligase	-0.247	0.302	0.414	0.635
Lysine–tRNA ligase	-0.230	0.296	0.438	0.635
Lysozyme	0.038	0.447	0.932	0.968
Malate dehydrogenase	-0.230	0.296	0.438	0.635
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))	-0.230	0.296	0.438	0.635
Maltose alpha-D-glucosyltransferase	-0.629	0.781	0.422	0.635
Maltose O-acetyltransferase	-0.230	0.328	0.484	0.635
Mannan endo-1,4-beta-mannosidase	-0.329	0.354	0.354	0.635
Mannonate dehydratase	-0.692	0.616	0.263	0.635
Mannose-1-phosphate guanylyltransferase	-0.230	0.296	0.438	0.635
Mannose-6-phosphate isomerase	-0.230	0.296	0.438	0.635
Methenyltetrahydrofolate cyclohydrolase	-0.230	0.296	0.438	0.635
Methionine–tRNA ligase	-0.230	0.296	0.438	0.635
Methionine adenosyltransferase	-0.243	0.292	0.407	0.635
Methionine synthase	-0.206	0.312	0.510	0.635
Methionyl-tRNA formyltransferase	-0.230	0.296	0.438	0.635
Methionyl aminopeptidase	-0.224	0.289	0.440	0.635
Methylaspartate ammonia-lyase	-0.221	0.572	0.699	0.790
Methylaspartate mutase	-0.221	0.572	0.699	0.790
Methylated-DNA–[protein]-cysteine S-methyltransferase	-0.230	0.296	0.438	0.635
Methylenetetrahydrofolate dehydrogenase (NADP(+))	-0.230	0.296	0.438	0.635
Methylenetetrahydrofolate reductase (NAD(P)H)	-0.264	0.307	0.391	0.635
Methylmalonyl-CoA mutase	-0.246	0.310	0.427	0.635
N-acetyl-gamma-glutamyl-phosphate reductase	-0.100	1.127	0.930	0.968
N-acetylmuramic acid 6-phosphate etherase	-0.747	0.519	0.152	0.635
N-acetylmuramoyl-L-alanine amidase	-0.285	0.315	0.367	0.635
N-acetylneuraminate lyase	-0.206	0.295	0.486	0.635
N-acetylneuraminate synthase	-2.232	1.933	0.250	0.635
N-acylglucosamine 2-epimerase	-0.240	0.289	0.409	0.635
N-acylneuraminate cytidylyltransferase	-2.232	1.933	0.250	0.635
N-carbamoylputrescine amidase	-0.230	0.296	0.438	0.635
N-succinylornithine carbamoyltransferase	-0.100	1.127	0.930	0.968
N(6)-L-threonylcarbamoyladenine synthase	-0.230	0.296	0.438	0.635
NAD(+) diphosphatase	-0.230	0.296	0.438	0.635
NAD(+) kinase	-0.230	0.296	0.438	0.635
NAD(+) synthase (glutamine-hydrolyzing)	-0.230	0.296	0.438	0.635
NAD(P)H-hydrate epimerase	-0.230	0.296	0.438	0.635
NADH dehydrogenase	-0.211	0.290	0.469	0.635
NADH:ubiquinone reductase (H(+)-translocating)	-0.230	0.296	0.438	0.635
Nicotinamidase	-0.097	0.315	0.757	0.845
Nicotinamide-nucleotide amidase	-0.230	0.296	0.438	0.635
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase	-0.680	0.538	0.208	0.635
Nicotinate-nucleotide adenylyltransferase	-0.230	0.296	0.438	0.635
Nicotinate-nucleotide diphosphorylase (carboxylating)	-0.172	0.328	0.602	0.718
Nicotinate phosphoribosyltransferase	-0.231	0.296	0.438	0.635
Nitric-oxide reductase (cytochrome c)	0.054	0.493	0.913	0.968
Nitrite reductase (cytochrome; ammonia-forming)	-0.217	0.299	0.469	0.635
Nitrous-oxide reductase	-0.319	0.983	0.746	0.837
Non-reducing end alpha-L-arabinofuranosidase	-0.691	0.615	0.263	0.635
Non-specific serine/threonine protein kinase	-0.044	0.314	0.889	0.968
Nucleoside-diphosphate kinase	-0.754	1.120	0.502	0.635
O-acetylhomoserine aminocarboxypropyltransferase	-0.208	0.306	0.498	0.635
o-succinylbenzoate–CoA ligase	-0.219	0.301	0.468	0.635
Oligonucleotidase	-0.230	0.296	0.438	0.635
Orotate phosphoribosyltransferase	-0.230	0.296	0.438	0.635
Orotidine-5’-phosphate decarboxylase	-0.230	0.296	0.438	0.635
Pantetheine-phosphate adenylyltransferase	-0.230	0.296	0.438	0.635
Pantoate–beta-alanine ligase (AMP-forming)	-0.213	0.298	0.477	0.635
Pantothenate kinase	-0.230	0.296	0.438	0.635
Pectinesterase	-0.674	0.651	0.302	0.635
Peptide-methionine (R)-S-oxide reductase	-0.230	0.296	0.438	0.635
Peptide-methionine (S)-S-oxide reductase	-0.230	0.296	0.438	0.635
Peptide chain release factor N(5)-glutamine methyltransferase	-0.230	0.296	0.438	0.635
Peptide deformylase	-0.230	0.296	0.438	0.635
Peptidyl-dipeptidase Dcp	-0.233	0.311	0.453	0.635
Peptidylprolyl isomerase	-0.215	0.294	0.466	0.635
Peroxiredoxin	-0.236	0.295	0.424	0.635
Phenylalanine–tRNA ligase	-0.230	0.296	0.438	0.635
Phosphate acetyltransferase	-0.230	0.296	0.438	0.635
Phosphate butyryltransferase	-0.147	0.329	0.655	0.755
Phosphatidate cytidylyltransferase	-0.230	0.296	0.438	0.635
Phosphatidylglycerophosphatase	-0.015	0.569	0.979	0.997
Phosphatidylserine decarboxylase	-0.230	0.296	0.438	0.635
Phospho-N-acetylmuramoyl-pentapeptide-transferase	-0.230	0.296	0.438	0.635
Phosphoadenylyl-sulfate reductase (thioredoxin)	18.519	3411.091	0.996	0.997
Phosphoenolpyruvate carboxykinase (ATP)	-0.230	0.296	0.438	0.635
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)	-0.230	0.296	0.438	0.635
Phosphoglycerate dehydrogenase	-0.228	0.293	0.436	0.635
Phosphoglycerate kinase	-0.230	0.296	0.438	0.635
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)	0.038	0.480	0.937	0.969
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)	-0.291	0.314	0.356	0.635
Phosphoglycolate phosphatase	-0.223	0.280	0.427	0.635
Phosphomannomutase	-0.230	0.296	0.438	0.635
Phosphomethylpyrimidine kinase	-0.134	0.312	0.669	0.765
Phosphomethylpyrimidine synthase	0.014	0.383	0.970	0.997
Phosphopantothenate–cysteine ligase	-0.213	0.298	0.477	0.635
Phosphopantothenoylcysteine decarboxylase	-0.213	0.298	0.477	0.635
Phosphopyruvate hydratase	-0.230	0.296	0.438	0.635
Phosphoribosyl-AMP cyclohydrolase	-0.100	1.127	0.930	0.968
Phosphoribosyl-ATP diphosphatase	-0.100	1.127	0.930	0.968
Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase	-0.230	0.296	0.438	0.635
Phosphoribosylamine–glycine ligase	-0.230	0.296	0.438	0.635
Phosphoribosylaminoimidazolecarboxamide formyltransferase	-0.230	0.296	0.438	0.635
Phosphoribosylaminoimidazolesuccinocarboxamide synthase	-0.230	0.296	0.438	0.635
Phosphoribosylanthranilate isomerase	-0.219	0.301	0.468	0.635
Phosphoribosylformylglycinamidine cyclo-ligase	-0.230	0.296	0.438	0.635
Phosphoribosylformylglycinamidine synthase	-0.220	0.308	0.477	0.635
Phosphoribosylglycinamide formyltransferase	-0.219	0.308	0.477	0.635
Phosphoserine phosphatase	-0.237	0.319	0.459	0.635
Phosphoserine transaminase	-0.228	0.293	0.436	0.635
Polar-amino-acid-transporting ATPase	-2.168	1.874	0.249	0.635
Polynucleotide adenylyltransferase	-0.754	1.120	0.502	0.635
Polyribonucleotide nucleotidyltransferase	-0.230	0.296	0.438	0.635
Potassium-transporting ATPase	2.304	1.989	0.248	0.635
Prephenate dehydratase	-0.644	0.452	0.157	0.635
PreQ(1) synthase	-0.230	0.296	0.438	0.635
Proline–tRNA ligase	-0.230	0.296	0.438	0.635
Prolyl aminopeptidase	18.519	3411.091	0.996	0.997
Prolyl oligopeptidase	-0.210	0.327	0.521	0.645
Protein-disulfide reductase	-0.230	0.296	0.438	0.635
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	-0.137	0.613	0.823	0.905
Protein-tyrosine-phosphatase	-0.237	0.301	0.432	0.635
Protoporphyrinogen oxidase	-0.232	0.293	0.430	0.635
Pullulanase	-0.252	0.318	0.429	0.635
Purine-nucleoside phosphorylase	-0.230	0.296	0.438	0.635
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing)	-0.219	0.301	0.468	0.635
Pyridoxal kinase	-0.186	0.306	0.545	0.671
Pyridoxine 5’-phosphate synthase	-0.754	1.120	0.502	0.635
Pyrroline-5-carboxylate reductase	0.139	1.250	0.912	0.968
Pyruvate carboxylase	-0.230	0.296	0.438	0.635
Pyruvate kinase	-0.230	0.296	0.438	0.635
Pyruvate synthase	-0.230	0.296	0.438	0.635
Pyruvate, phosphate dikinase	-0.230	0.296	0.438	0.635
Quinolinate synthase	-0.172	0.328	0.602	0.718
Rhamnulokinase	-0.810	0.830	0.330	0.635
Rhamnulose-1-phosphate aldolase	-0.810	0.830	0.330	0.635
Riboflavin kinase	-0.230	0.296	0.438	0.635
Riboflavin synthase	-0.230	0.296	0.438	0.635
Ribonuclease H	-0.230	0.296	0.438	0.635
Ribonuclease III	-0.217	0.299	0.469	0.635
Ribonuclease P	-0.230	0.296	0.438	0.635
Ribonuclease Z	-0.230	0.296	0.438	0.635
Ribonucleoside-diphosphate reductase	-0.160	0.292	0.584	0.707
Ribonucleoside-triphosphate reductase	-0.230	0.296	0.438	0.635
Ribose-5-phosphate isomerase	-0.230	0.296	0.438	0.635
Ribose-phosphate diphosphokinase	-0.230	0.296	0.438	0.635
Ribulose-phosphate 3-epimerase	-0.230	0.296	0.438	0.635
RNA-directed DNA polymerase	2.304	1.989	0.248	0.635
RNA helicase	-0.230	0.296	0.438	0.635
RNA ligase (ATP)	-2.232	1.933	0.250	0.635
S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-0.225	0.301	0.457	0.635
S-ribosylhomocysteine lyase	-0.263	0.312	0.401	0.635
Saccharopine dehydrogenase (NAD(+), L-lysine-forming)	-0.230	0.296	0.438	0.635
Selenocysteine lyase	-0.230	0.296	0.438	0.635
Serine–tRNA ligase	-0.230	0.296	0.438	0.635
Serine-type D-Ala-D-Ala carboxypeptidase	-0.288	0.314	0.360	0.635
Serine O-acetyltransferase	-0.157	0.290	0.590	0.713
Shikimate dehydrogenase	-0.230	0.296	0.438	0.635
Shikimate kinase	-0.230	0.296	0.438	0.635
Sialate O-acetylesterase	-0.283	0.313	0.368	0.635
Signal peptidase I	-0.223	0.297	0.456	0.635
Signal peptidase II	-0.230	0.296	0.438	0.635
Site-specific DNA-methyltransferase (adenine-specific)	-0.214	0.306	0.485	0.635
Starch synthase	-0.230	0.296	0.438	0.635
Succinate–CoA ligase (ADP-forming)	-0.173	0.329	0.600	0.718
Succinate dehydrogenase (quinone)	-0.230	0.296	0.438	0.635
Sulfate adenylyltransferase	-0.754	1.120	0.502	0.635
Superoxide dismutase	-0.396	0.395	0.317	0.635
Superoxide reductase	-0.166	0.321	0.605	0.718
synthase	-0.230	0.296	0.438	0.635
Tagaturonate reductase	-0.676	0.652	0.302	0.635
Tetraacyldisaccharide 4’-kinase	-0.230	0.296	0.438	0.635
Tetrahydrofolate synthase	-0.230	0.296	0.438	0.635
Thiamine-phosphate diphosphorylase	-0.063	0.337	0.853	0.934
Thiamine-phosphate kinase	-0.230	0.296	0.438	0.635
Thiamine diphosphokinase	-0.198	0.307	0.519	0.643
Thiazole synthase	18.519	3411.091	0.996	0.997
Thioredoxin-disulfide reductase	-0.230	0.296	0.438	0.635
Threonine–tRNA ligase	-0.230	0.296	0.438	0.635
Threonine ammonia-lyase	-0.378	0.462	0.414	0.635
Threonine synthase	-0.606	0.561	0.282	0.635
Thymidine kinase	-0.230	0.296	0.438	0.635
Thymidylate synthase	-0.172	0.309	0.579	0.704
Thymidylate synthase (FAD)	-0.625	0.575	0.278	0.635
Transketolase	-0.234	0.306	0.446	0.635
Triose-phosphate isomerase	-0.240	0.307	0.435	0.635
Tripeptide aminopeptidase	-0.230	0.296	0.438	0.635
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase	-0.230	0.296	0.438	0.635
tRNA-guanine(34) transglycosylase	-0.230	0.296	0.438	0.635
tRNA (guanine(37)-N(1))-methyltransferase	-0.230	0.296	0.438	0.635
tRNA (guanine(46)-N(7))-methyltransferase	-0.230	0.296	0.438	0.635
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	-0.230	0.296	0.438	0.635
tRNA dimethylallyltransferase	-0.230	0.296	0.438	0.635
tRNA pseudouridine(32) synthase	-0.223	0.336	0.508	0.635
tRNA pseudouridine(38-40) synthase	-0.230	0.296	0.438	0.635
tRNA pseudouridine(55) synthase	-0.230	0.296	0.438	0.635
tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase	-0.230	0.296	0.438	0.635
tRNA(adenine(34)) deaminase	-0.230	0.296	0.438	0.635
tRNA(Ile)-lysidine synthetase	-0.230	0.296	0.438	0.635
Tryptophan–tRNA ligase	-0.230	0.296	0.438	0.635
Tryptophan synthase	-0.229	0.301	0.447	0.635
Tryptophanase	-0.221	0.572	0.699	0.790
Type I site-specific deoxyribonuclease	-0.237	0.303	0.435	0.635
Type II site-specific deoxyribonuclease	-0.343	0.461	0.459	0.635
Type III site-specific deoxyribonuclease	-5.080	10.936	0.643	0.745
Tyrosine–tRNA ligase	-0.230	0.296	0.438	0.635
UDP-2,3-diacylglucosamine diphosphatase	-0.230	0.296	0.438	0.635
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-0.230	0.296	0.438	0.635
UDP-3-O-acyl-N-acetylglucosamine deacetylase	-0.230	0.296	0.438	0.635
UDP-galactopyranose mutase	-0.337	0.418	0.421	0.635
UDP-glucose 4-epimerase	-0.241	0.294	0.412	0.635
UDP-glucose 6-dehydrogenase	-0.219	0.308	0.477	0.635
UDP-glucuronate 4-epimerase	-0.057	0.574	0.921	0.968
UDP-glucuronate decarboxylase	-0.137	0.613	0.823	0.905
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-0.230	0.296	0.438	0.635
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	-0.287	0.294	0.330	0.635
UDP-N-acetylmuramate–L-alanine ligase	-0.230	0.296	0.438	0.635
UDP-N-acetylmuramate dehydrogenase	-0.230	0.296	0.438	0.635
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase	-0.230	0.296	0.438	0.635
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	-0.230	0.296	0.438	0.635
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase	-0.230	0.296	0.438	0.635
UMP kinase	-0.230	0.296	0.438	0.635
UMP/CMP kinase	-0.230	0.296	0.438	0.635
Undecaprenyl-diphosphate phosphatase	-0.274	0.301	0.364	0.635
Uracil-DNA glycosylase	-0.204	0.307	0.507	0.635
Uracil phosphoribosyltransferase	-0.230	0.296	0.438	0.635
Uridine kinase	-0.230	0.296	0.438	0.635
Uridine phosphorylase	-0.230	0.296	0.438	0.635
Urocanate hydratase	-0.162	0.333	0.626	0.734
Uroporphyrinogen-III synthase	-0.248	0.296	0.403	0.635
Valine–tRNA ligase	-0.230	0.296	0.438	0.635
Xaa-Pro aminopeptidase	-0.233	0.297	0.434	0.635
Xanthine phosphoribosyltransferase	-0.156	0.300	0.605	0.718
XTP/dITP diphosphatase	-0.230	0.296	0.438	0.635
Xylose isomerase	-0.092	1.135	0.935	0.969
Xylulokinase	-0.546	0.585	0.352	0.635
Zinc-exporting ATPase	-0.201	0.284	0.481	0.635

# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ec_stratefied_prevo_data_results.csv", row.names = F)

Part 2 KO Data

descriptions <- readr::read_tsv("data/PICRUST/ko_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.

colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/KO_prevo.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,.fns = sum))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  ) %>%
  mutate(
    ID = substr(ID, 2, 99)
  )

d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)

Joining, by = "ID"

Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object

mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(ID) %>%
  mutate(
    dem = ifelse(sum(Abundance)==0, 1, sum(Abundance)),
    RelAbundance = Abundance/dem*100) %>%
  ungroup()%>%
  group_by(description)%>%
  mutate(avgRA = mean(RelAbundance))

Abundance

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(RelAbundance),
            Overall.SE = sd(RelAbundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(RelAbundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra <- left_join(tb.ra1, tb.ra2m)

Joining, by = "description"

tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )


kable(tb.ra, format="html", digits=5, caption="Stratefied KO Data - Prevotella spp. (genus level only): Average RelAbundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")

Stratefied KO Data - Prevotella spp. (genus level only): Average RelAbundance of Each Description (sorted in descending order)

description	Overall Mean	Overall SE	Tumor Mean	Tumor Var	Tumor SE	Tumor Ng	Non-Tumor Mean	Non-Tumor Var	Non-Tumor SE	Non-Tumor Ng	SEpooled	t	df	p	fdr_p
rpoE; RNA polymerase sigma-70 factor, ECF subfamily	0.60820	0.03108	0.64798	0.12618	0.04406	65	0.58039	0.17083	0.04286	93	0.06147	1.09959	149.379	0.27328	0.40992
TC.FEV.OM; iron complex outermembrane recepter protein	0.56645	0.02877	0.61137	0.11142	0.04140	65	0.53505	0.14332	0.03926	93	0.05705	1.33758	147.737	0.18309	0.30818
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial	0.33043	0.01770	0.35661	0.04427	0.02610	65	0.31213	0.05287	0.02384	93	0.03535	1.25829	145.101	0.21031	0.34268
fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8]	0.31007	0.01556	0.34047	0.03353	0.02271	65	0.28883	0.04087	0.02096	93	0.03091	1.67089	145.859	0.09689	0.23153
hlpA, ompH; outer membrane protein	0.30286	0.01505	0.33066	0.03064	0.02171	65	0.28344	0.03881	0.02043	93	0.02981	1.58388	147.213	0.11537	0.23153
acm; lysozyme	0.29051	0.01543	0.31531	0.03337	0.02266	65	0.27317	0.04027	0.02081	93	0.03076	1.37007	145.497	0.17278	0.29466
ABC-2.P; ABC-2 type transport system permease protein	0.28741	0.01529	0.31044	0.03292	0.02251	65	0.27131	0.03952	0.02061	93	0.03052	1.28199	145.292	0.20189	0.33020
tonB; periplasmic protein TonB	0.27255	0.01476	0.30222	0.03252	0.02237	65	0.25182	0.03510	0.01943	93	0.02963	1.70106	141.125	0.09113	0.23153
topB; DNA topoisomerase III [EC:5.99.1.2]	0.24004	0.01388	0.25976	0.02789	0.02072	65	0.22626	0.03209	0.01858	93	0.02782	1.20375	143.677	0.23066	0.36341
hupB; DNA-binding protein HU-beta	0.23916	0.01204	0.25950	0.01946	0.01730	65	0.22494	0.02505	0.01641	93	0.02385	1.44928	147.758	0.14938	0.27457
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102]	0.22715	0.01129	0.24799	0.01724	0.01628	65	0.21258	0.02183	0.01532	93	0.02236	1.58388	147.213	0.11537	0.23153
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]	0.22715	0.01129	0.24799	0.01724	0.01628	65	0.21258	0.02183	0.01532	93	0.02236	1.58388	147.213	0.11537	0.23153
ABC-2.A; ABC-2 type transport system ATP-binding protein	0.22551	0.01205	0.24118	0.02031	0.01768	65	0.21456	0.02476	0.01632	93	0.02406	1.10671	145.859	0.27024	0.40626
pqqL; zinc protease [EC:3.4.24.-]	0.22030	0.01175	0.24047	0.01899	0.01709	65	0.20621	0.02350	0.01590	93	0.02334	1.46745	146.397	0.14440	0.26754
rpoD; RNA polymerase primary sigma factor	0.21601	0.01084	0.23685	0.01607	0.01572	65	0.20144	0.02001	0.01467	93	0.02150	1.64697	146.628	0.10171	0.23153
HEXA_B; hexosaminidase [EC:3.2.1.52]	0.21344	0.01346	0.23216	0.02826	0.02085	65	0.20037	0.02879	0.01759	93	0.02728	1.16526	138.671	0.24592	0.38224
K07133; uncharacterized protein	0.21333	0.01136	0.23039	0.01800	0.01664	65	0.20140	0.02192	0.01535	93	0.02264	1.28013	145.825	0.20253	0.33080
lacZ; beta-galactosidase [EC:3.2.1.23]	0.21093	0.01242	0.22759	0.02244	0.01858	65	0.19928	0.02566	0.01661	93	0.02492	1.13591	143.443	0.25789	0.39294
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]	0.21016	0.01081	0.22473	0.01535	0.01537	65	0.19997	0.02056	0.01487	93	0.02138	1.15781	149.037	0.24879	0.38414
ampG; MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG	0.19585	0.01001	0.21459	0.01385	0.01460	65	0.18274	0.01696	0.01350	93	0.01989	1.60164	146.012	0.11140	0.23153
yfbK; Ca-activated chloride channel homolog	0.19015	0.00989	0.20627	0.01347	0.01440	65	0.17889	0.01667	0.01339	93	0.01966	1.39272	146.403	0.16581	0.29098
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]	0.18742	0.01019	0.20431	0.01518	0.01528	65	0.17561	0.01707	0.01355	93	0.02042	1.40492	142.768	0.16222	0.28900
K07025; putative hydrolase of the HAD superfamily	0.18508	0.00979	0.20178	0.01313	0.01421	65	0.17341	0.01636	0.01326	93	0.01944	1.45885	146.647	0.14675	0.27108
gpx; glutathione peroxidase [EC:1.11.1.9]	0.17688	0.00942	0.19277	0.01262	0.01394	65	0.16577	0.01485	0.01264	93	0.01881	1.43485	144.544	0.15349	0.27772
FUCA; alpha-L-fucosidase [EC:3.2.1.51]	0.17043	0.00936	0.18172	0.01201	0.01359	65	0.16254	0.01510	0.01274	93	0.01863	1.02962	146.976	0.30488	0.43751
lacI, galR; LacI family transcriptional regulator	0.16916	0.00913	0.18385	0.01174	0.01344	65	0.15888	0.01403	0.01228	93	0.01821	1.37163	145.118	0.17230	0.29428
ENDOG; endonuclease G, mitochondrial	0.16836	0.00888	0.18396	0.01093	0.01297	65	0.15746	0.01336	0.01198	93	0.01766	1.50035	145.950	0.13568	0.25590
TC.FEV.OM2, cirA, cfrA, hmuR; outer membrane receptor for ferrienterochelin and colicins	0.16668	0.00890	0.18167	0.01139	0.01324	65	0.15621	0.01315	0.01189	93	0.01779	1.43096	143.815	0.15461	0.27888
parA, soj; chromosome partitioning protein	0.16529	0.00885	0.17727	0.01045	0.01268	65	0.15692	0.01366	0.01212	93	0.01754	1.16031	148.261	0.24779	0.38309
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]	0.15913	0.00814	0.17280	0.00900	0.01177	65	0.14957	0.01136	0.01105	93	0.01615	1.43841	147.074	0.15244	0.27669
uvrA; excinuclease ABC subunit A	0.15864	0.00812	0.17514	0.00942	0.01204	65	0.14711	0.01090	0.01083	93	0.01619	1.73161	143.909	0.08549	0.23153
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]	0.15804	0.00812	0.17370	0.00944	0.01205	65	0.14709	0.01090	0.01082	93	0.01620	1.64266	143.819	0.10264	0.23153
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12]	0.15533	0.00782	0.16801	0.00806	0.01114	65	0.14647	0.01070	0.01073	93	0.01546	1.39343	148.774	0.16557	0.29098
K08303; putative protease [EC:3.4.-.-]	0.15450	0.00777	0.16977	0.00844	0.01139	65	0.14383	0.01015	0.01045	93	0.01546	1.67862	145.356	0.09537	0.23153
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]	0.15450	0.00777	0.16977	0.00844	0.01139	65	0.14383	0.01015	0.01045	93	0.01546	1.67862	145.356	0.09537	0.23153
relA; GTP pyrophosphokinase [EC:2.7.6.5]	0.15234	0.00758	0.16644	0.00779	0.01095	65	0.14249	0.00982	0.01028	93	0.01502	1.59496	147.049	0.11287	0.23153
manC, cpsB; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]	0.15162	0.00753	0.16578	0.00771	0.01089	65	0.14172	0.00970	0.01021	93	0.01493	1.61144	146.984	0.10923	0.23153
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
fusA, GFM, EFG; elongation factor G	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
lolC_E; lipoprotein-releasing system permease protein	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
pepD; dipeptidase D [EC:3.4.13.-]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
udk, UCK; uridine kinase [EC:2.7.1.48]	0.15143	0.00752	0.16533	0.00766	0.01086	65	0.14172	0.00970	0.01021	93	0.01491	1.58388	147.213	0.11537	0.23153
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]	0.15083	0.00751	0.16388	0.00765	0.01085	65	0.14170	0.00970	0.01021	93	0.01490	1.48877	147.245	0.13869	0.26029
exbB; biopolymer transport protein ExbB	0.14964	0.00746	0.16364	0.00757	0.01079	65	0.13986	0.00952	0.01012	93	0.01479	1.60801	146.972	0.10998	0.23153
K06950; uncharacterized protein	0.14964	0.00746	0.16364	0.00757	0.01079	65	0.13986	0.00952	0.01012	93	0.01479	1.60801	146.972	0.10998	0.23153
BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40]	0.14873	0.00743	0.16253	0.00749	0.01073	65	0.13909	0.00943	0.01007	93	0.01472	1.59272	147.007	0.11337	0.23153
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]	0.14845	0.00945	0.15496	0.01364	0.01448	65	0.14389	0.01455	0.01251	93	0.01914	0.57837	140.648	0.56394	0.66569
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]	0.14785	0.00867	0.16112	0.01132	0.01320	65	0.13857	0.01219	0.01145	93	0.01747	1.29082	141.024	0.19888	0.32713
gph; phosphoglycolate phosphatase [EC:3.1.3.18]	0.14660	0.00778	0.16063	0.00873	0.01159	65	0.13680	0.01001	0.01037	93	0.01555	1.53227	143.569	0.12766	0.24515
dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5]	0.14537	0.00753	0.15942	0.00799	0.01109	65	0.13555	0.00949	0.01010	93	0.01500	1.59118	144.917	0.11375	0.23153
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	0.14398	0.00732	0.15634	0.00741	0.01068	65	0.13535	0.00912	0.00990	93	0.01456	1.44105	146.185	0.15171	0.27622
ABC-2.TX; HlyD family secretion protein	0.14362	0.00727	0.15407	0.00712	0.01047	65	0.13631	0.00917	0.00993	93	0.01443	1.23056	147.762	0.22044	0.35455
coaE; dephospho-CoA kinase [EC:2.7.1.24]	0.14296	0.00724	0.15602	0.00711	0.01046	65	0.13384	0.00898	0.00983	93	0.01435	1.54529	147.100	0.12443	0.24217
K07098; uncharacterized protein	0.14256	0.00729	0.15464	0.00742	0.01068	65	0.13412	0.00901	0.00984	93	0.01453	1.41266	145.734	0.15989	0.28676
asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA	0.14243	0.00721	0.15383	0.00704	0.01040	65	0.13447	0.00897	0.00982	93	0.01431	1.35304	147.433	0.17812	0.30243
korA, oorA, oforA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]	0.14225	0.00720	0.15337	0.00700	0.01038	65	0.13447	0.00897	0.00982	93	0.01429	1.32309	147.602	0.18785	0.31435
korB, oorB, oforB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]	0.14225	0.00720	0.15337	0.00700	0.01038	65	0.13447	0.00897	0.00982	93	0.01429	1.32309	147.602	0.18785	0.31435
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]	0.14184	0.00719	0.15383	0.00704	0.01040	65	0.13347	0.00887	0.00977	93	0.01427	1.42673	147.054	0.15578	0.28011
galM, GALM; aldose 1-epimerase [EC:5.1.3.3]	0.14183	0.00720	0.15238	0.00699	0.01037	65	0.13445	0.00897	0.00982	93	0.01428	1.25549	147.629	0.21129	0.34315
folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]	0.14152	0.00717	0.15272	0.00694	0.01033	65	0.13370	0.00887	0.00977	93	0.01422	1.33756	147.553	0.18310	0.30818
TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family	0.14042	0.00721	0.15343	0.00713	0.01047	65	0.13134	0.00887	0.00977	93	0.01432	1.54262	146.622	0.12508	0.24217
chrA; chromate transporter	0.13987	0.00743	0.15047	0.00802	0.01111	65	0.13245	0.00918	0.00994	93	0.01491	1.20911	143.476	0.22861	0.36067
map; methionyl aminopeptidase [EC:3.4.11.18]	0.13852	0.00710	0.15048	0.00692	0.01031	65	0.13016	0.00859	0.00961	93	0.01410	1.44166	146.537	0.15153	0.27622
acrA, mexA, adeI, smeD, mtrC, cmeA; membrane fusion protein, multidrug efflux system	0.13744	0.00714	0.14860	0.00709	0.01045	65	0.12964	0.00868	0.00966	93	0.01423	1.33214	145.996	0.18489	0.31029
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family	0.13744	0.00714	0.14860	0.00709	0.01045	65	0.12964	0.00868	0.00966	93	0.01423	1.33214	145.996	0.18489	0.31029
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator	0.13611	0.00747	0.14338	0.00772	0.01090	65	0.13103	0.00961	0.01016	93	0.01490	0.82874	146.607	0.40860	0.52632
K07095; uncharacterized protein	0.13570	0.00739	0.14419	0.00785	0.01099	65	0.12976	0.00919	0.00994	93	0.01482	0.97385	144.345	0.33176	0.44209
SPP; sucrose-6-phosphatase [EC:3.1.3.24]	0.13269	0.00693	0.14663	0.00669	0.01015	65	0.12294	0.00805	0.00931	93	0.01377	1.72111	145.373	0.08736	0.23153
ytfE, scdA; regulator of cell morphogenesis and NO signaling	0.13254	0.00692	0.14422	0.00665	0.01012	65	0.12437	0.00813	0.00935	93	0.01377	1.44108	145.927	0.15171	0.27622
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	0.13190	0.00902	0.15123	0.01255	0.01390	65	0.11839	0.01275	0.01171	93	0.01817	1.80706	138.566	0.07292	0.23153
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4]	0.12970	0.00684	0.13858	0.00650	0.01000	65	0.12349	0.00800	0.00928	93	0.01364	1.10613	146.186	0.27049	0.40626
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	0.12896	0.00678	0.14334	0.00652	0.01001	65	0.11891	0.00760	0.00904	93	0.01349	1.81119	144.221	0.07219	0.23153
acpP; acyl carrier protein	0.12803	0.00773	0.13091	0.00757	0.01079	65	0.12603	0.01083	0.01079	93	0.01526	0.31966	150.965	0.74967	0.80755
SIAE; sialate O-acetylesterase [EC:3.1.1.53]	0.12799	0.00784	0.13305	0.00827	0.01128	65	0.12444	0.01080	0.01078	93	0.01560	0.55163	148.240	0.58203	0.67874
mrdA; penicillin-binding protein 2 [EC:3.4.16.4]	0.12744	0.00675	0.14141	0.00642	0.00994	65	0.11769	0.00759	0.00903	93	0.01343	1.76618	144.744	0.07947	0.23153
aspB; aspartate aminotransferase [EC:2.6.1.1]	0.12739	0.00725	0.13708	0.00745	0.01070	65	0.12062	0.00887	0.00976	93	0.01449	1.13640	144.989	0.25767	0.39294
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]	0.12621	0.00719	0.13684	0.00735	0.01064	65	0.11878	0.00871	0.00968	93	0.01438	1.25651	144.779	0.21095	0.34310
pepO; putative endopeptidase [EC:3.4.24.-]	0.12601	0.00672	0.13943	0.00639	0.00992	65	0.11663	0.00752	0.00899	93	0.01339	1.70274	144.534	0.09077	0.23153
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4]	0.12586	0.00675	0.13781	0.00629	0.00984	65	0.11751	0.00772	0.00911	93	0.01341	1.51356	146.090	0.13230	0.25033
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]	0.12391	0.00658	0.13402	0.00595	0.00957	65	0.11685	0.00740	0.00892	93	0.01308	1.31236	146.576	0.19145	0.31853
moxR; MoxR-like ATPase [EC:3.6.3.-]	0.12123	0.00651	0.13528	0.00607	0.00967	65	0.11141	0.00698	0.00866	93	0.01298	1.83939	143.632	0.06792	0.23153
glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	0.11923	0.00637	0.12997	0.00577	0.00942	65	0.11172	0.00679	0.00854	93	0.01272	1.43497	144.545	0.15346	0.27772
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]	0.11616	0.00631	0.12651	0.00560	0.00928	65	0.10893	0.00671	0.00849	93	0.01258	1.39727	145.199	0.16446	0.29098
E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4]	0.11393	0.00624	0.12555	0.00557	0.00926	65	0.10581	0.00646	0.00833	93	0.01246	1.58497	143.959	0.11517	0.23153
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]	0.11132	0.00657	0.11410	0.00541	0.00912	65	0.10938	0.00788	0.00920	93	0.01296	0.36449	151.447	0.71600	0.79489
bglX; beta-glucosidase [EC:3.2.1.21]	0.10935	0.01120	0.10421	0.01668	0.01602	65	0.11295	0.02219	0.01545	93	0.02225	-0.39300	148.820	0.69488	0.77746
K06871; uncharacterized protein	0.10934	0.00636	0.11961	0.00568	0.00934	65	0.10217	0.00685	0.00858	93	0.01269	1.37403	145.471	0.17155	0.29378
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]	0.10715	0.00606	0.12010	0.00549	0.00919	65	0.09811	0.00587	0.00794	93	0.01215	1.81089	140.712	0.07229	0.23153
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]	0.10596	0.00656	0.12092	0.00700	0.01038	65	0.09551	0.00647	0.00834	93	0.01332	1.90842	134.407	0.05847	0.23153
cysE; serine O-acetyltransferase [EC:2.3.1.30]	0.10445	0.00608	0.11476	0.00537	0.00909	65	0.09724	0.00609	0.00810	93	0.01217	1.43880	143.155	0.15239	0.27669
hsdM; type I restriction enzyme M protein [EC:2.1.1.72]	0.10290	0.00634	0.10801	0.00611	0.00970	65	0.09933	0.00655	0.00839	93	0.01282	0.67637	140.781	0.49992	0.60634
fucP; MFS transporter, FHS family, L-fucose permease	0.10287	0.00589	0.11110	0.00499	0.00876	65	0.09713	0.00579	0.00789	93	0.01179	1.18452	143.987	0.23816	0.37248
lepB; signal peptidase I [EC:3.4.21.89]	0.10260	0.00631	0.11414	0.00659	0.01007	65	0.09453	0.00600	0.00803	93	0.01288	1.52265	133.734	0.13021	0.24759
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]	0.10203	0.00555	0.10630	0.00390	0.00775	65	0.09905	0.00558	0.00775	93	0.01096	0.66141	150.968	0.50936	0.61377
K07481; transposase, IS5 family	0.10110	0.01066	0.11685	0.01857	0.01690	65	0.09009	0.01744	0.01369	93	0.02176	1.23014	135.088	0.22078	0.35460
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]	0.09968	0.00645	0.11106	0.00643	0.00995	65	0.09174	0.00659	0.00842	93	0.01303	1.48256	138.958	0.14046	0.26172
E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22]	0.09793	0.00637	0.10541	0.00580	0.00945	65	0.09271	0.00683	0.00857	93	0.01276	0.99593	144.582	0.32095	0.43751
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2]	0.09734	0.00535	0.10760	0.00413	0.00797	65	0.09018	0.00472	0.00712	93	0.01069	1.63046	143.410	0.10520	0.23153
glk; glucokinase [EC:2.7.1.2]	0.09720	0.00545	0.10530	0.00433	0.00816	65	0.09154	0.00493	0.00728	93	0.01094	1.25810	143.236	0.21040	0.34268
bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]	0.09704	0.00534	0.10337	0.00382	0.00767	65	0.09261	0.00499	0.00733	93	0.01061	1.01429	148.250	0.31210	0.43751
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	0.09574	0.00531	0.10398	0.00398	0.00783	65	0.08997	0.00476	0.00716	93	0.01061	1.32104	145.174	0.18857	0.31509
K07052; uncharacterized protein	0.09411	0.00537	0.09918	0.00338	0.00721	65	0.09057	0.00539	0.00761	93	0.01049	0.82141	153.503	0.41269	0.52981
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]	0.09066	0.00494	0.09753	0.00329	0.00711	65	0.08585	0.00425	0.00676	93	0.00981	1.19025	147.899	0.23586	0.37059
eptC; heptose-I-phosphate ethanolaminephosphotransferase [EC:2.7.8.-]	0.09023	0.00532	0.09842	0.00439	0.00822	65	0.08450	0.00450	0.00696	93	0.01077	1.29249	138.929	0.19833	0.32713
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]	0.08978	0.00604	0.09373	0.00530	0.00903	65	0.08702	0.00614	0.00812	93	0.01215	0.55213	143.953	0.58171	0.67874
AMY, amyA, malS; alpha-amylase [EC:3.2.1.1]	0.08950	0.00511	0.09851	0.00354	0.00738	65	0.08321	0.00447	0.00693	93	0.01013	1.51141	147.067	0.13283	0.25092
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14]	0.08918	0.00488	0.09590	0.00309	0.00689	65	0.08448	0.00423	0.00674	93	0.00964	1.18386	149.686	0.23835	0.37248
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]	0.08743	0.00476	0.09606	0.00321	0.00703	65	0.08140	0.00379	0.00639	93	0.00950	1.54357	144.669	0.12488	0.24217
phoN; acid phosphatase (class A) [EC:3.1.3.2]	0.08726	0.00673	0.09577	0.00697	0.01036	65	0.08131	0.00727	0.00884	93	0.01362	1.06142	139.659	0.29033	0.42619
ABC-2.OM, wza; polysaccharide biosynthesis/export protein	0.08720	0.00467	0.09312	0.00286	0.00664	65	0.08306	0.00385	0.00644	93	0.00925	1.08789	149.211	0.27840	0.41652
cpdB; 2’,3’-cyclic-nucleotide 2’-phosphodiesterase / 3’-nucleotidase [EC:3.1.4.16 3.1.3.6]	0.08720	0.00467	0.09312	0.00286	0.00664	65	0.08306	0.00385	0.00644	93	0.00925	1.08789	149.211	0.27840	0.41652
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	0.08660	0.00468	0.09560	0.00327	0.00709	65	0.08031	0.00353	0.00616	93	0.00940	1.62662	141.095	0.10605	0.23153
radA, sms; DNA repair protein RadA/Sms	0.08629	0.00463	0.09201	0.00279	0.00655	65	0.08230	0.00379	0.00639	93	0.00915	1.06193	149.498	0.28998	0.42619
feoB; ferrous iron transport protein B	0.08485	0.00465	0.09302	0.00313	0.00694	65	0.07913	0.00357	0.00619	93	0.00930	1.49264	143.269	0.13773	0.25934
crcB, FEX; fluoride exporter	0.08436	0.00451	0.09162	0.00273	0.00648	65	0.07929	0.00353	0.00616	93	0.00894	1.37838	147.853	0.17017	0.29333
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]	0.08420	0.00462	0.09470	0.00356	0.00740	65	0.07686	0.00315	0.00582	93	0.00941	1.89524	132.461	0.06024	0.23153
tatD; TatD DNase family protein [EC:3.1.21.-]	0.08418	0.00453	0.09197	0.00280	0.00657	65	0.07874	0.00351	0.00615	93	0.00899	1.47120	146.865	0.14338	0.26608
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]	0.08293	0.00450	0.09248	0.00311	0.00692	65	0.07625	0.00319	0.00586	93	0.00906	1.79056	139.000	0.07554	0.23153
fldA, nifF, isiB; flavodoxin I	0.08293	0.00450	0.09248	0.00311	0.00692	65	0.07625	0.00319	0.00586	93	0.00906	1.79056	139.000	0.07554	0.23153
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]	0.08293	0.00450	0.09248	0.00311	0.00692	65	0.07625	0.00319	0.00586	93	0.00906	1.79056	139.000	0.07554	0.23153
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17	0.08293	0.00450	0.09248	0.00311	0.00692	65	0.07625	0.00319	0.00586	93	0.00906	1.79056	139.000	0.07554	0.23153
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5]	0.08293	0.00450	0.09248	0.00311	0.00692	65	0.07625	0.00319	0.00586	93	0.00906	1.79056	139.000	0.07554	0.23153
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13]	0.08261	0.00568	0.08762	0.00507	0.00883	65	0.07911	0.00514	0.00743	93	0.01154	0.73721	138.453	0.46224	0.57956
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]	0.08248	0.00589	0.08885	0.00542	0.00913	65	0.07802	0.00555	0.00773	93	0.01196	0.90534	138.949	0.36685	0.47947
copB; Cu2+-exporting ATPase [EC:3.6.3.4]	0.08239	0.00438	0.09028	0.00263	0.00636	65	0.07688	0.00327	0.00593	93	0.00870	1.54205	146.519	0.12522	0.24217
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14]	0.08151	0.00481	0.08532	0.00315	0.00696	65	0.07884	0.00403	0.00658	93	0.00958	0.67693	147.598	0.49951	0.60634
lemA; LemA protein	0.08107	0.00440	0.08803	0.00273	0.00648	65	0.07620	0.00327	0.00593	93	0.00878	1.34563	145.243	0.18052	0.30472
vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]	0.08105	0.00458	0.08949	0.00333	0.00715	65	0.07515	0.00325	0.00591	93	0.00928	1.54530	136.792	0.12458	0.24217
K07005; uncharacterized protein	0.08083	0.00439	0.08854	0.00285	0.00662	65	0.07544	0.00315	0.00582	93	0.00881	1.48603	141.999	0.13949	0.26095
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]	0.08022	0.00416	0.08825	0.00250	0.00620	65	0.07461	0.00286	0.00554	93	0.00832	1.64017	143.509	0.10316	0.23153
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]	0.08017	0.00416	0.08799	0.00247	0.00616	65	0.07471	0.00289	0.00557	93	0.00831	1.59919	144.310	0.11197	0.23153
metK; S-adenosylmethionine synthetase [EC:2.5.1.6]	0.08017	0.00416	0.08799	0.00247	0.00616	65	0.07471	0.00289	0.00557	93	0.00831	1.59919	144.310	0.11197	0.23153
fic; cell filamentation protein	0.08011	0.00422	0.08937	0.00272	0.00647	65	0.07364	0.00280	0.00549	93	0.00848	1.85444	139.105	0.06579	0.23153
K07085; putative transport protein	0.07896	0.00411	0.08635	0.00235	0.00601	65	0.07380	0.00286	0.00555	93	0.00818	1.53440	145.873	0.12710	0.24448
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	0.07879	0.00410	0.08711	0.00248	0.00617	65	0.07297	0.00272	0.00540	93	0.00820	1.72409	141.759	0.08687	0.23153
lon; ATP-dependent Lon protease [EC:3.4.21.53]	0.07879	0.00410	0.08711	0.00248	0.00617	65	0.07297	0.00272	0.00540	93	0.00820	1.72409	141.759	0.08687	0.23153
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]	0.07879	0.00410	0.08711	0.00248	0.00617	65	0.07297	0.00272	0.00540	93	0.00820	1.72409	141.759	0.08687	0.23153
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]	0.07879	0.00410	0.08711	0.00248	0.00617	65	0.07297	0.00272	0.00540	93	0.00820	1.72409	141.759	0.08687	0.23153
URA4, pyrC; dihydroorotase [EC:3.5.2.3]	0.07879	0.00410	0.08711	0.00248	0.00617	65	0.07297	0.00272	0.00540	93	0.00820	1.72409	141.759	0.08687	0.23153
uup; ABC transport system ATP-binding/permease protein	0.07879	0.00410	0.08711	0.00248	0.00617	65	0.07297	0.00272	0.00540	93	0.00820	1.72409	141.759	0.08687	0.23153
K07011; uncharacterized protein	0.07855	0.00402	0.08432	0.00203	0.00559	65	0.07451	0.00290	0.00558	93	0.00790	1.24135	150.863	0.21640	0.34980
aspA; aspartate ammonia-lyase [EC:4.3.1.1]	0.07837	0.00437	0.08545	0.00241	0.00609	65	0.07341	0.00342	0.00606	93	0.00859	1.40148	150.772	0.16313	0.29017
rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]	0.07806	0.00419	0.08564	0.00255	0.00626	65	0.07275	0.00288	0.00557	93	0.00838	1.53891	143.067	0.12604	0.24325
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]	0.07791	0.00632	0.08606	0.00621	0.00978	65	0.07221	0.00637	0.00827	93	0.01281	1.08059	138.933	0.28175	0.41851
comM; magnesium chelatase family protein	0.07770	0.00396	0.08360	0.00198	0.00552	65	0.07358	0.00282	0.00550	93	0.00779	1.28489	150.846	0.20080	0.32937
ftsZ; cell division protein FtsZ	0.07769	0.00397	0.08480	0.00214	0.00574	65	0.07272	0.00269	0.00538	93	0.00787	1.53550	146.945	0.12681	0.24434
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	0.07754	0.00392	0.08489	0.00213	0.00573	65	0.07240	0.00260	0.00529	93	0.00779	1.60224	145.811	0.11127	0.23153
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]	0.07752	0.00395	0.08314	0.00195	0.00547	65	0.07358	0.00282	0.00550	93	0.00776	1.23170	151.281	0.21997	0.35428
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198]	0.07751	0.00396	0.08435	0.00211	0.00570	65	0.07272	0.00269	0.00538	93	0.00784	1.48355	147.441	0.14006	0.26160
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]	0.07681	0.00384	0.08423	0.00203	0.00558	65	0.07163	0.00249	0.00518	93	0.00762	1.65445	146.205	0.10018	0.23153
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]	0.07663	0.00382	0.08378	0.00200	0.00554	65	0.07163	0.00249	0.00518	93	0.00758	1.60156	146.755	0.11140	0.23153
ssb; single-strand DNA-binding protein	0.07663	0.00382	0.08378	0.00200	0.00554	65	0.07163	0.00249	0.00518	93	0.00758	1.60156	146.755	0.11140	0.23153
greA; transcription elongation factor GreA	0.07649	0.00383	0.08312	0.00195	0.00547	65	0.07186	0.00254	0.00523	93	0.00757	1.48674	148.262	0.13921	0.26085
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	0.07643	0.00381	0.08352	0.00198	0.00551	65	0.07148	0.00249	0.00517	93	0.00756	1.59413	146.988	0.11306	0.23153
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	0.07643	0.00381	0.08352	0.00198	0.00551	65	0.07148	0.00249	0.00517	93	0.00756	1.59413	146.988	0.11306	0.23153
hemD, UROS; uroporphyrinogen-III synthase [EC:4.2.1.75]	0.07631	0.00382	0.08266	0.00192	0.00543	65	0.07186	0.00254	0.00523	93	0.00754	1.43307	148.798	0.15394	0.27809
K09155; uncharacterized protein	0.07614	0.00384	0.08366	0.00212	0.00571	65	0.07088	0.00243	0.00511	93	0.00766	1.66767	143.501	0.09756	0.23153
yjbB; phosphate:Na+ symporter	0.07590	0.00378	0.08312	0.00195	0.00547	65	0.07086	0.00243	0.00511	93	0.00749	1.63742	146.633	0.10369	0.23153
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]	0.07573	0.00376	0.08266	0.00192	0.00543	65	0.07089	0.00243	0.00511	93	0.00745	1.57980	147.242	0.11630	0.23300
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ABC.FEV.P; iron complex transport system permease protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ABC.FEV.S; iron complex transport system substrate-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ABC.SN.S; NitT/TauT family transport system substrate-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ABCF3; ATP-binding cassette, subfamily F, member 3	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ackA; acetate kinase [EC:2.7.2.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
adk, AK; adenylate kinase [EC:2.7.4.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
aguB; N-carbamoylputrescine amidase [EC:3.5.1.53]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
AIBP, nnrE; NAD(P)H-hydrate epimerase [EC:5.1.99.6]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
alr; alanine racemase [EC:5.1.1.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
apbE; FAD:protein FMN transferase [EC:2.7.1.180]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
argR, ahrC; transcriptional regulator of arginine metabolism	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
AROA1, aroA; chorismate mutase [EC:5.4.99.5]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
aroB; 3-dehydroquinate synthase [EC:4.2.3.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
aroC; chorismate synthase [EC:4.2.3.5]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
aroE; shikimate dehydrogenase [EC:1.1.1.25]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ATPF0A, atpB; F-type H+-transporting ATPase subunit a	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ATPF0B, atpF; F-type H+-transporting ATPase subunit b	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ATPF0C, atpE; F-type H+-transporting ATPase subunit c	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
bamD; outer membrane protein assembly factor BamD	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
BCP, PRXQ, DOT5; peroxiredoxin Q/BCP [EC:1.11.1.15]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
cdd, CDA; cytidine deaminase [EC:3.5.4.5]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
clpC; ATP-dependent Clp protease ATP-binding subunit ClpC	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
cmk; CMP/dCMP kinase [EC:2.7.4.25]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
comEB; dCMP deaminase [EC:3.5.4.12]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
comEC; competence protein ComEC	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
corA; magnesium transporter	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
cydA; cytochrome bd ubiquinol oxidase subunit I [EC:1.10.3.14]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
cydB; cytochrome bd ubiquinol oxidase subunit II [EC:1.10.3.14]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dgt; dGTPase [EC:3.1.5.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dinB; DNA polymerase IV [EC:2.7.7.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dnaA; chromosomal replication initiator protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dnaB; replicative DNA helicase [EC:3.6.4.12]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dnaG; DNA primase [EC:2.7.7.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dnaJ; molecular chaperone DnaJ	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dnaK, HSPA9; molecular chaperone DnaK	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
DPP3; dipeptidyl-peptidase III [EC:3.4.14.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dsbD; thiol:disulfide interchange protein DsbD [EC:1.8.1.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E3.2.1.1A; alpha-amylase [EC:3.2.1.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E3.6.1.22, NUDT12, nudC; NAD+ diphosphatase [EC:3.6.1.22]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E4.2.1.2A, fumA, fumB; fumarate hydratase, class I [EC:4.2.1.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E6.3.5.1, NADSYN1, QNS1, nadE; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
efp; elongation factor P	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
engA, der; GTPase	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
engB; GTP-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ENO, eno; enolase [EC:4.2.1.11]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
entC; isochorismate synthase [EC:5.4.4.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
era, ERAL1; GTPase	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
fixA, etfB; electron transfer flavoprotein beta subunit	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
fixB, etfA; electron transfer flavoprotein alpha subunit	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
folP; dihydropteroate synthase [EC:2.5.1.15]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
frr, MRRF, RRF; ribosome recycling factor	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ftsA; cell division protein FtsA	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ftsE; cell division transport system ATP-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ftsK, spoIIIE; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ftsQ; cell division protein FtsQ	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ftsW, spoVE; cell division protein FtsW	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ftsX; cell division transport system permease protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ftsY; fused signal recognition particle receptor	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
glgA; starch synthase [EC:2.4.1.21]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
gmd, GMDS; GDPmannose 4,6-dehydratase [EC:4.2.1.47]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
groEL, HSPD1; chaperonin GroEL	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
groES, HSPE1; chaperonin GroES	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
GRPE; molecular chaperone GrpE	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
gyrA; DNA gyrase subunit A [EC:5.99.1.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
gyrB; DNA gyrase subunit B [EC:5.99.1.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
hflX; GTPase	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
HINT1, hinT, hit; histidine triad (HIT) family protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
holA; DNA polymerase III subunit delta [EC:2.7.7.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
hprA; glycerate dehydrogenase [EC:1.1.1.29]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
hslR; ribosome-associated heat shock protein Hsp15	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
HSP90A, htpG; molecular chaperone HtpG	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
infA; translation initiation factor IF-1	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
infB, MTIF2; translation initiation factor IF-2	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
infC, MTIF3; translation initiation factor IF-3	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
K00243; uncharacterized protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
K06890; uncharacterized protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
K07027; glycosyltransferase 2 family protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
K07037; uncharacterized protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
K07082; UPF0755 protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
K07137; uncharacterized protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
K07164; uncharacterized protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
K09861; uncharacterized protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
kdtA, waaA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
korC, oorC; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
korD, oorD; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lepA; GTP-binding protein LepA	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lptF; lipopolysaccharide export system permease protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lptG; lipopolysaccharide export system permease protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lspA; signal peptidase II [EC:3.4.23.36]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
lysC; aspartate kinase [EC:2.7.2.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
maf; septum formation protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
manB; phosphomannomutase [EC:5.4.2.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mdh; malate dehydrogenase [EC:1.1.1.37]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
menB; naphthoate synthase [EC:4.1.3.36]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
menD; 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:2.2.1.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
motB; chemotaxis protein MotB	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mreB; rod shape-determining protein MreB and related proteins	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mreC; rod shape-determining protein MreC	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mrp, NUBPL; ATP-binding protein involved in chromosome partitioning	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mscL; large conductance mechanosensitive channel	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mtgA; monofunctional glycosyltransferase [EC:2.4.1.129]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
murI; glutamate racemase [EC:5.1.1.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mutL; DNA mismatch repair protein MutL	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mutS; DNA mismatch repair protein MutS	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mutS2; DNA mismatch repair protein MutS2	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nfrA2; FMN reductase [NAD(P)H] [EC:1.5.1.39]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nqrA; Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC:1.6.5.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nqrB; Na+-transporting NADH:ubiquinone oxidoreductase subunit B [EC:1.6.5.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nqrC; Na+-transporting NADH:ubiquinone oxidoreductase subunit C [EC:1.6.5.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nqrD; Na+-transporting NADH:ubiquinone oxidoreductase subunit D [EC:1.6.5.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nqrE; Na+-transporting NADH:ubiquinone oxidoreductase subunit E [EC:1.6.5.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nqrF; Na+-transporting NADH:ubiquinone oxidoreductase subunit F [EC:1.6.5.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nspC; carboxynorspermidine decarboxylase [EC:4.1.1.96]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
NTH; endonuclease III [EC:4.2.99.18]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoA; NADH-quinone oxidoreductase subunit A [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoB; NADH-quinone oxidoreductase subunit B [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoH; NADH-quinone oxidoreductase subunit H [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoI; NADH-quinone oxidoreductase subunit I [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoJ; NADH-quinone oxidoreductase subunit J [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoK; NADH-quinone oxidoreductase subunit K [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoL; NADH-quinone oxidoreductase subunit L [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoM; NADH-quinone oxidoreductase subunit M [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nuoN; NADH-quinone oxidoreductase subunit N [EC:1.6.5.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nupG; MFS transporter, NHS family, nucleoside permease	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nusA; N utilization substance protein A	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nusB; N utilization substance protein B	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
nusG; transcriptional antiterminator NusG	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
obgE, cgtA; GTPase [EC:3.6.5.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
parB, spo0J; chromosome partitioning protein, ParB family	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
parC; topoisomerase IV subunit A [EC:5.99.1.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
parE; topoisomerase IV subunit B [EC:5.99.1.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
PDF, def; peptide deformylase [EC:3.5.1.88]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pepT; tripeptide aminopeptidase [EC:3.4.11.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pfp, PFP; diphosphate-dependent phosphofructokinase [EC:2.7.1.90]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pgm; phosphoglucomutase [EC:5.4.2.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
phnP; phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [EC:3.1.4.55]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
phoH, phoL; phosphate starvation-inducible protein PhoH and related proteins	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
PK, pyk; pyruvate kinase [EC:2.7.1.40]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pnuC; nicotinamide mononucleotide transporter	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
polA; DNA polymerase I [EC:2.7.7.7]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ppnK, NADK; NAD+ kinase [EC:2.7.1.23]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
prfA, MTRF1, MRF1; peptide chain release factor 1	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
prfB; peptide chain release factor 2	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
prfC; peptide chain release factor 3	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pstS; phosphate transport system substrate-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pycB; pyruvate carboxylase subunit B [EC:6.4.1.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pyrDII; dihydroorotate dehydrogenase electron transfer subunit	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pyrG, CTPS; CTP synthase [EC:6.3.4.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pyrH; uridylate kinase [EC:2.7.4.22]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pyrI; aspartate carbamoyltransferase regulatory subunit	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
queG; epoxyqueuosine reductase [EC:1.17.99.6]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
radC; DNA repair protein RadC	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rbfA; ribosome-binding factor A	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
recA; recombination protein RecA	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
recF; DNA replication and repair protein RecF	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
recN; DNA repair protein RecN (Recombination protein N)	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
recO; DNA repair protein RecO (recombination protein O)	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
recR; recombination protein RecR	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
recX; regulatory protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rho; transcription termination factor Rho	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rimM; 16S rRNA processing protein RimM	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rimP; ribosome maturation factor RimP	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rmuC; DNA recombination protein RmuC	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rng, cafA; ribonuclease G [EC:3.1.26.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rnhB; ribonuclease HII [EC:3.1.26.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rnpA; ribonuclease P protein component [EC:3.1.26.5]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rnr, vacB; ribonuclease R [EC:3.1.-.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rny; ribonucrease Y [EC:3.1.-.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rnz; ribonuclease Z [EC:3.1.26.11]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rodA, mrdB; rod shape determining protein RodA	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L25, rplY; large subunit ribosomal protein L25	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L29, rpmC; large subunit ribosomal protein L29	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L31, rpmE; large subunit ribosomal protein L31	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S1, rpsA; small subunit ribosomal protein S1	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S13, rpsM; small subunit ribosomal protein S13	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S19, rpsS; small subunit ribosomal protein S19	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S20, rpsT; small subunit ribosomal protein S20	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S3, rpsC; small subunit ribosomal protein S3	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S4, rpsD; small subunit ribosomal protein S4	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S8, rpsH; small subunit ribosomal protein S8	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rpoN; RNA polymerase sigma-54 factor	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rseP; regulator of sigma E protease [EC:3.4.24.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ruvX; putative holliday junction resolvase [EC:3.1.-.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
SAM50, TOB55, bamA; outer membrane protein insertion porin family	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
sdhB, frdB; succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.1 1.3.5.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
sdhC, frdC; succinate dehydrogenase / fumarate reductase, cytochrome b subunit	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
secA; preprotein translocase subunit SecA	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
secDF; SecD/SecF fusion protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
secG; preprotein translocase subunit SecG	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
secY; preprotein translocase subunit SecY	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
smf; DNA processing protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
smpB; SsrA-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
speA; arginine decarboxylase [EC:4.1.1.19]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
spoU; RNA methyltransferase, TrmH family	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
sppA; protease IV [EC:3.4.21.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
sufB; Fe-S cluster assembly protein SufB	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
sufC; Fe-S cluster assembly ATP-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
sufD; Fe-S cluster assembly protein SufD	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
sufE; cysteine desulfuration protein SufE	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
surE; 5’-nucleotidase [EC:3.1.3.5]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
TC.CIC; chloride channel protein, CIC family	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
TC.POT; proton-dependent oligopeptide transporter, POT family	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tdk, TK; thymidine kinase [EC:2.7.1.21]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
thiJ; protein deglycase [EC:3.5.1.124]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
thiL; thiamine-monophosphate kinase [EC:2.7.4.16]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tig; trigger factor	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
topA; DNA topoisomerase I [EC:5.99.1.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
trkA, ktrA; trk system potassium uptake protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
trkH, trkG, ktrB; trk system potassium uptake protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
trxA; thioredoxin 1	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tsf, TSFM; elongation factor Ts	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
TSTA3, fcl; GDP-L-fucose synthase [EC:1.1.1.271]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
tuf, TUFM; elongation factor Tu	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
typA, bipA; GTP-binding protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
udp, UPP; uridine phosphorylase [EC:2.4.2.3]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
uvrB; excinuclease ABC subunit B	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
uvrC; excinuclease ABC subunit C	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
xerC; integrase/recombinase XerC	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
xerD; integrase/recombinase XerD	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
yajC; preprotein translocase subunit YajC	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ybeB; ribosome-associated protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ycaJ; putative ATPase	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ychF; ribosome-binding ATPase	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
yfiC, trmX; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
yfiH; polyphenol oxidase [EC:1.10.3.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
yggS, PROSC; PLP dependent protein	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
yraN; putative endonuclease	0.07572	0.00376	0.08266	0.00192	0.00543	65	0.07086	0.00243	0.00511	93	0.00745	1.58388	147.213	0.11537	0.23153
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]	0.07553	0.00376	0.08221	0.00191	0.00542	65	0.07086	0.00243	0.00511	93	0.00745	1.52421	147.312	0.12960	0.24692
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15]	0.07553	0.00376	0.08221	0.00191	0.00542	65	0.07086	0.00243	0.00511	93	0.00745	1.52421	147.312	0.12960	0.24692
TC.KEF; monovalent cation:H+ antiporter-2, CPA2 family	0.07549	0.00411	0.08552	0.00246	0.00615	65	0.06847	0.00272	0.00541	93	0.00819	2.08130	142.123	0.03920	0.23153
TC.BASS; bile acid:Na+ symporter, BASS family	0.07518	0.00377	0.08246	0.00199	0.00553	65	0.07009	0.00239	0.00507	93	0.00750	1.64899	145.418	0.10131	0.23153
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5]	0.07513	0.00376	0.08266	0.00192	0.00543	65	0.06986	0.00240	0.00508	93	0.00744	1.72184	146.905	0.08720	0.23153
panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]	0.07513	0.00376	0.08266	0.00192	0.00543	65	0.06986	0.00240	0.00508	93	0.00744	1.72184	146.905	0.08720	0.23153
panC; pantoate–beta-alanine ligase [EC:6.3.2.1]	0.07513	0.00376	0.08266	0.00192	0.00543	65	0.06986	0.00240	0.00508	93	0.00744	1.72184	146.905	0.08720	0.23153
panD; aspartate 1-decarboxylase [EC:4.1.1.11]	0.07513	0.00376	0.08266	0.00192	0.00543	65	0.06986	0.00240	0.00508	93	0.00744	1.72184	146.905	0.08720	0.23153
mltD, dniR; membrane-bound lytic murein transglycosylase D [EC:4.2.2.-]	0.07511	0.00378	0.08122	0.00198	0.00552	65	0.07084	0.00242	0.00511	93	0.00752	1.38064	146.048	0.16950	0.29333
oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator	0.07494	0.00375	0.08221	0.00191	0.00542	65	0.06986	0.00240	0.00508	93	0.00743	1.66216	147.005	0.09861	0.23153
dapdh; diaminopimelate dehydrogenase [EC:1.4.1.16]	0.07481	0.00374	0.08155	0.00189	0.00540	65	0.07009	0.00239	0.00507	93	0.00740	1.54797	147.134	0.12378	0.24171
K07139; uncharacterized protein	0.07481	0.00374	0.08155	0.00189	0.00540	65	0.07009	0.00239	0.00507	93	0.00740	1.54797	147.134	0.12378	0.24171
malY, malT; maltose/moltooligosaccharide transporter	0.07481	0.00374	0.08155	0.00189	0.00540	65	0.07009	0.00239	0.00507	93	0.00740	1.54797	147.134	0.12378	0.24171
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34	0.07481	0.00374	0.08155	0.00189	0.00540	65	0.07009	0.00239	0.00507	93	0.00740	1.54797	147.134	0.12378	0.24171
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]	0.07481	0.00374	0.08155	0.00189	0.00540	65	0.07009	0.00239	0.00507	93	0.00740	1.54797	147.134	0.12378	0.24171
serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52]	0.07481	0.00374	0.08155	0.00189	0.00540	65	0.07009	0.00239	0.00507	93	0.00740	1.54797	147.134	0.12378	0.24171
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]	0.07460	0.00467	0.08256	0.00323	0.00705	65	0.06904	0.00356	0.00619	93	0.00938	1.44185	141.941	0.15155	0.27622
SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5	0.07446	0.00379	0.08138	0.00195	0.00548	65	0.06961	0.00245	0.00514	93	0.00751	1.56780	147.001	0.11908	0.23734
E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48]	0.07439	0.00377	0.08041	0.00198	0.00552	65	0.07019	0.00242	0.00510	93	0.00752	1.35944	146.018	0.17610	0.29989
nrfA; nitrite reductase (cytochrome c-552) [EC:1.7.2.2]	0.07433	0.00377	0.08076	0.00197	0.00551	65	0.06984	0.00240	0.00508	93	0.00749	1.45792	145.849	0.14701	0.27108
nrfH; cytochrome c nitrite reductase small subunit	0.07433	0.00377	0.08076	0.00197	0.00551	65	0.06984	0.00240	0.00508	93	0.00749	1.45792	145.849	0.14701	0.27108
K07000; uncharacterized protein	0.07411	0.00376	0.08143	0.00195	0.00548	65	0.06900	0.00239	0.00507	93	0.00747	1.66499	146.036	0.09806	0.23153
coaW; type II pantothenate kinase [EC:2.7.1.33]	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
E3.1.3.5; 5’-nucleotidase [EC:3.1.3.5]	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10]	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
ftnA, ftn; ferritin [EC:1.16.3.2]	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
K09125; uncharacterized protein	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
menE; O-succinylbenzoic acid—CoA ligase [EC:6.2.1.26]	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6]	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6]	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24]	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
zapA; cell division protein ZapA	0.07393	0.00375	0.08098	0.00192	0.00543	65	0.06900	0.00239	0.00507	93	0.00743	1.61181	146.658	0.10915	0.23153
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]	0.07392	0.00380	0.08218	0.00190	0.00541	65	0.06814	0.00249	0.00517	93	0.00749	1.87655	148.240	0.06254	0.23153
hcp; hydroxylamine reductase [EC:1.7.99.1]	0.07386	0.00381	0.08112	0.00201	0.00557	65	0.06878	0.00245	0.00513	93	0.00757	1.63041	145.713	0.10517	0.23153
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease	0.07374	0.00374	0.08052	0.00191	0.00542	65	0.06900	0.00239	0.00507	93	0.00743	1.55234	146.787	0.12273	0.24171
rlpA; rare lipoprotein A	0.07373	0.00380	0.08173	0.00190	0.00540	65	0.06814	0.00249	0.00517	93	0.00748	1.81748	148.342	0.07116	0.23153
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54]	0.07361	0.00374	0.08011	0.00195	0.00548	65	0.06907	0.00237	0.00504	93	0.00745	1.48171	145.657	0.14058	0.26172
ybdG, mscM; miniconductance mechanosensitive channel	0.07332	0.00376	0.07953	0.00198	0.00552	65	0.06898	0.00239	0.00507	93	0.00749	1.40871	145.558	0.16105	0.28737
K08999; uncharacterized protein	0.07302	0.00372	0.07987	0.00189	0.00540	65	0.06823	0.00235	0.00503	93	0.00738	1.57731	146.596	0.11688	0.23336
pyrP, uraA; uracil permease	0.07283	0.00371	0.07941	0.00188	0.00538	65	0.06823	0.00235	0.00503	93	0.00737	1.51760	146.746	0.13127	0.24919
K07007; uncharacterized protein	0.07260	0.00376	0.07872	0.00197	0.00551	65	0.06833	0.00239	0.00507	93	0.00749	1.38830	145.542	0.16717	0.29098
thyA, TYMS; thymidylate synthase [EC:2.1.1.45]	0.07143	0.00447	0.08038	0.00307	0.00687	65	0.06518	0.00315	0.00582	93	0.00900	1.68884	138.988	0.09349	0.23153
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]	0.07141	0.00377	0.08043	0.00190	0.00541	65	0.06511	0.00241	0.00509	93	0.00743	2.06193	147.224	0.04097	0.23153
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2]	0.07085	0.00383	0.07895	0.00200	0.00555	65	0.06519	0.00249	0.00517	93	0.00758	1.81463	146.567	0.07163	0.23153
galK; galactokinase [EC:2.7.1.6]	0.07068	0.00374	0.07689	0.00201	0.00556	65	0.06634	0.00232	0.00500	93	0.00747	1.41162	143.879	0.16022	0.28676
K08998; uncharacterized protein	0.07068	0.00374	0.07689	0.00201	0.00556	65	0.06634	0.00232	0.00500	93	0.00747	1.41162	143.879	0.16022	0.28676
dps; starvation-inducible DNA-binding protein	0.07047	0.00378	0.07544	0.00213	0.00572	65	0.06699	0.00234	0.00501	93	0.00761	1.11051	141.798	0.26866	0.40456
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	0.07030	0.00394	0.07454	0.00221	0.00583	65	0.06733	0.00262	0.00530	93	0.00788	0.91370	144.741	0.36239	0.47472
maa; maltose O-acetyltransferase [EC:2.3.1.79]	0.07021	0.00400	0.07670	0.00231	0.00596	65	0.06567	0.00266	0.00535	93	0.00801	1.37714	143.668	0.17061	0.29356
PPOX, hemY; protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15]	0.06982	0.00372	0.07575	0.00203	0.00559	65	0.06567	0.00227	0.00494	93	0.00746	1.35116	142.627	0.17878	0.30268
tex; protein Tex	0.06976	0.00369	0.07623	0.00195	0.00548	65	0.06524	0.00227	0.00494	93	0.00738	1.48917	144.137	0.13863	0.26029
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3]	0.06851	0.00372	0.07285	0.00198	0.00552	65	0.06547	0.00233	0.00500	93	0.00745	0.99027	144.500	0.32370	0.43751
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]	0.06851	0.00372	0.07285	0.00198	0.00552	65	0.06547	0.00233	0.00500	93	0.00745	0.99027	144.500	0.32370	0.43751
npdA; NAD-dependent deacetylase [EC:3.5.1.-]	0.06851	0.00372	0.07285	0.00198	0.00552	65	0.06547	0.00233	0.00500	93	0.00745	0.99027	144.500	0.32370	0.43751
yhbH; putative sigma-54 modulation protein	0.06851	0.00372	0.07285	0.00198	0.00552	65	0.06547	0.00233	0.00500	93	0.00745	0.99027	144.500	0.32370	0.43751
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	0.06832	0.00371	0.07240	0.00197	0.00550	65	0.06547	0.00233	0.00500	93	0.00744	0.93132	144.778	0.35324	0.46483
kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29]	0.06804	0.00527	0.07143	0.00403	0.00787	65	0.06567	0.00467	0.00708	93	0.01059	0.54443	143.949	0.58699	0.68383
fruA; fructan beta-fructosidase [EC:3.2.1.80]	0.06790	0.00373	0.07140	0.00202	0.00557	65	0.06545	0.00233	0.00500	93	0.00749	0.79520	143.811	0.42781	0.54380
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12]	0.06760	0.00368	0.07174	0.00194	0.00546	65	0.06470	0.00229	0.00496	93	0.00738	0.95419	144.676	0.34158	0.45143
mraZ; MraZ protein	0.06760	0.00368	0.07174	0.00194	0.00546	65	0.06470	0.00229	0.00496	93	0.00738	0.95419	144.676	0.34158	0.45143
HSP20; HSP20 family protein	0.06752	0.00372	0.07070	0.00201	0.00556	65	0.06530	0.00232	0.00500	93	0.00747	0.72254	143.952	0.47114	0.58301
cutC; copper homeostasis protein	0.06752	0.00370	0.07143	0.00195	0.00547	65	0.06478	0.00232	0.00499	93	0.00741	0.89787	144.940	0.37074	0.48293
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16]	0.06719	0.00369	0.07219	0.00198	0.00552	65	0.06370	0.00226	0.00493	93	0.00740	1.14755	143.403	0.25306	0.38814
pulA; pullulanase [EC:3.2.1.41]	0.06672	0.00368	0.07116	0.00195	0.00548	65	0.06361	0.00228	0.00495	93	0.00738	1.02340	144.183	0.30783	0.43751
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	0.06658	0.00373	0.07231	0.00196	0.00549	65	0.06258	0.00235	0.00503	93	0.00744	1.30606	145.315	0.19360	0.32026
secE; preprotein translocase subunit SecE	0.06616	0.00363	0.07260	0.00184	0.00531	65	0.06166	0.00223	0.00489	93	0.00722	1.51502	145.681	0.13193	0.25005
lldE; L-lactate dehydrogenase complex protein LldE	0.06613	0.00367	0.07116	0.00195	0.00548	65	0.06261	0.00225	0.00492	93	0.00736	1.16232	143.700	0.24703	0.38244
lldF; L-lactate dehydrogenase complex protein LldF	0.06613	0.00367	0.07116	0.00195	0.00548	65	0.06261	0.00225	0.00492	93	0.00736	1.16232	143.700	0.24703	0.38244
lldG; L-lactate dehydrogenase complex protein LldG	0.06613	0.00367	0.07116	0.00195	0.00548	65	0.06261	0.00225	0.00492	93	0.00736	1.16232	143.700	0.24703	0.38244
cbpA; curved DNA-binding protein	0.06612	0.00373	0.07237	0.00196	0.00549	65	0.06175	0.00233	0.00501	93	0.00743	1.42920	144.949	0.15510	0.27932
ina; immune inhibitor A [EC:3.4.24.-]	0.06611	0.00369	0.06972	0.00198	0.00552	65	0.06359	0.00227	0.00494	93	0.00741	0.82689	143.574	0.40967	0.52653
patB, malY; cystathione beta-lyase [EC:4.4.1.8]	0.06585	0.00370	0.06917	0.00198	0.00552	65	0.06353	0.00231	0.00498	93	0.00743	0.75842	144.231	0.44944	0.56632
nhaA; Na+:H+ antiporter, NhaA family	0.06571	0.00376	0.07038	0.00215	0.00575	65	0.06244	0.00229	0.00496	93	0.00759	1.04565	140.611	0.29752	0.43391
K06889; uncharacterized protein	0.06556	0.00394	0.06998	0.00219	0.00580	65	0.06247	0.00265	0.00534	93	0.00788	0.95356	145.626	0.34189	0.45143
trpB; tryptophan synthase beta chain [EC:4.2.1.20]	0.06447	0.00384	0.06911	0.00221	0.00583	65	0.06123	0.00242	0.00510	93	0.00774	1.01835	141.689	0.31025	0.43751
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8]	0.06423	0.00370	0.07220	0.00194	0.00547	65	0.05865	0.00227	0.00494	93	0.00737	1.83853	144.268	0.06804	0.23153
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]	0.06423	0.00370	0.07220	0.00194	0.00547	65	0.05865	0.00227	0.00494	93	0.00737	1.83853	144.268	0.06804	0.23153
ATOX1, ATX1, copZ, golB; copper chaperone	0.06419	0.00370	0.06917	0.00195	0.00548	65	0.06070	0.00230	0.00497	93	0.00740	1.14483	144.481	0.25417	0.38933
hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]	0.06404	0.00436	0.07216	0.00314	0.00695	65	0.05837	0.00286	0.00555	93	0.00890	1.55048	133.762	0.12339	0.24171
yrbG; cation:H+ antiporter	0.06404	0.00370	0.07175	0.00193	0.00545	65	0.05865	0.00227	0.00494	93	0.00735	1.78084	144.565	0.07704	0.23153
K07058; membrane protein	0.06402	0.00368	0.06991	0.00200	0.00555	65	0.05990	0.00221	0.00487	93	0.00739	1.35400	141.992	0.17789	0.30243
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	0.06378	0.00369	0.07122	0.00191	0.00542	65	0.05858	0.00227	0.00494	93	0.00733	1.72314	144.816	0.08700	0.23153
rnfG; electron transport complex protein RnfG	0.06360	0.00368	0.06917	0.00195	0.00548	65	0.05970	0.00226	0.00493	93	0.00737	1.28451	143.906	0.20103	0.32937
ndh; NADH dehydrogenase [EC:1.6.99.3]	0.06341	0.00362	0.06926	0.00188	0.00538	65	0.05932	0.00217	0.00483	93	0.00724	1.37484	143.778	0.17132	0.29378
PREP; prolyl oligopeptidase [EC:3.4.21.26]	0.06292	0.00371	0.06907	0.00199	0.00553	65	0.05861	0.00228	0.00495	93	0.00742	1.40935	143.563	0.16089	0.28737
TC.AGCS; alanine or glycine:cation symporter, AGCS family	0.06189	0.00589	0.06763	0.00533	0.00906	65	0.05788	0.00562	0.00777	93	0.01194	0.81760	140.104	0.41498	0.53216
K09704; uncharacterized protein	0.06151	0.00357	0.06674	0.00184	0.00532	65	0.05786	0.00212	0.00478	93	0.00715	1.24111	143.737	0.21659	0.34980
purT; phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2]	0.06149	0.00363	0.06872	0.00186	0.00535	65	0.05643	0.00220	0.00487	93	0.00723	1.69875	144.763	0.09151	0.23153
mp2; beta-1,4-mannooligosaccharide/beta-1,4-mannosyl-N-acetylglucosamine phosphorylase [EC:2.4.1.319 2.4.1.320]	0.06122	0.00359	0.06616	0.00181	0.00528	65	0.05777	0.00219	0.00485	93	0.00717	1.17120	145.487	0.24343	0.37889
NEU1; sialidase-1 [EC:3.2.1.18]	0.06122	0.00359	0.06616	0.00181	0.00528	65	0.05777	0.00219	0.00485	93	0.00717	1.17120	145.487	0.24343	0.37889
serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3]	0.06103	0.00358	0.06379	0.00196	0.00549	65	0.05911	0.00208	0.00473	93	0.00725	0.64545	140.417	0.51969	0.62363
xanP; xanthine permease XanP	0.06072	0.00367	0.06799	0.00195	0.00547	65	0.05564	0.00221	0.00488	93	0.00733	1.68468	143.230	0.09423	0.23153
RENBP; N-acylglucosamine 2-epimerase [EC:5.1.3.8]	0.06061	0.00359	0.06471	0.00183	0.00530	65	0.05775	0.00219	0.00485	93	0.00718	0.96980	145.221	0.33376	0.44424
pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-]	0.05948	0.00367	0.06899	0.00187	0.00536	65	0.05283	0.00223	0.00490	93	0.00726	2.22516	145.193	0.02761	0.23153
glxK, garK; glycerate 2-kinase [EC:2.7.1.165]	0.05947	0.00361	0.06439	0.00191	0.00543	65	0.05602	0.00215	0.00481	93	0.00725	1.15429	142.745	0.25031	0.38443
lipA; lipoyl synthase [EC:2.8.1.8]	0.05908	0.00388	0.06195	0.00204	0.00560	65	0.05708	0.00263	0.00532	93	0.00772	0.63050	147.835	0.52934	0.63324
K07001; NTE family protein	0.05894	0.00398	0.06157	0.00243	0.00612	65	0.05710	0.00258	0.00527	93	0.00807	0.55357	140.364	0.58075	0.67862
asnA; aspartate–ammonia ligase [EC:6.3.1.1]	0.05864	0.00350	0.06283	0.00179	0.00525	65	0.05570	0.00204	0.00468	93	0.00703	1.01338	143.230	0.31259	0.43751
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3]	0.05861	0.00359	0.06311	0.00187	0.00536	65	0.05548	0.00214	0.00480	93	0.00720	1.06037	143.648	0.29075	0.42619
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36	0.05850	0.00370	0.06554	0.00201	0.00556	65	0.05358	0.00223	0.00490	93	0.00741	1.61328	142.268	0.10890	0.23153
ahpF; alkyl hydroperoxide reductase subunit F [EC:1.6.4.-]	0.05754	0.00363	0.06421	0.00193	0.00544	65	0.05287	0.00216	0.00482	93	0.00727	1.55924	142.686	0.12116	0.24065
oprO_P; phosphate-selective porin OprO and OprP	0.05743	0.00360	0.06410	0.00183	0.00531	65	0.05277	0.00217	0.00483	93	0.00718	1.57768	144.747	0.11682	0.23336
AXY8, FUC95A, afcA; alpha-L-fucosidase 2 [EC:3.2.1.51]	0.05734	0.00363	0.06331	0.00200	0.00555	65	0.05316	0.00211	0.00476	93	0.00731	1.38904	140.221	0.16702	0.29098
perR; Fur family transcriptional regulator, peroxide stress response regulator	0.05702	0.00362	0.06239	0.00202	0.00558	65	0.05327	0.00210	0.00475	93	0.00733	1.24513	139.394	0.21517	0.34849
K06885; uncharacterized protein	0.05694	0.00366	0.06394	0.00198	0.00552	65	0.05204	0.00218	0.00484	93	0.00734	1.62213	141.886	0.10699	0.23153
lysA; diaminopimelate decarboxylase [EC:4.1.1.20]	0.05679	0.00359	0.05945	0.00191	0.00541	65	0.05493	0.00214	0.00480	93	0.00723	0.62500	142.721	0.53297	0.63496
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]	0.05679	0.00359	0.05945	0.00191	0.00541	65	0.05493	0.00214	0.00480	93	0.00723	0.62500	142.721	0.53297	0.63496
thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]	0.05679	0.00359	0.05945	0.00191	0.00541	65	0.05493	0.00214	0.00480	93	0.00723	0.62500	142.721	0.53297	0.63496
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]	0.05657	0.00360	0.06140	0.00199	0.00553	65	0.05319	0.00209	0.00474	93	0.00728	1.12742	140.106	0.26149	0.39582
gcvH, GCSH; glycine cleavage system H protein	0.05657	0.00360	0.06140	0.00199	0.00553	65	0.05319	0.00209	0.00474	93	0.00728	1.12742	140.106	0.26149	0.39582
gcvPA; glycine dehydrogenase subunit 1 [EC:1.4.4.2]	0.05657	0.00360	0.06140	0.00199	0.00553	65	0.05319	0.00209	0.00474	93	0.00728	1.12742	140.106	0.26149	0.39582
gcvPB; glycine dehydrogenase subunit 2 [EC:1.4.4.2]	0.05657	0.00360	0.06140	0.00199	0.00553	65	0.05319	0.00209	0.00474	93	0.00728	1.12742	140.106	0.26149	0.39582
gcvT, AMT; aminomethyltransferase [EC:2.1.2.10]	0.05657	0.00360	0.06140	0.00199	0.00553	65	0.05319	0.00209	0.00474	93	0.00728	1.12742	140.106	0.26149	0.39582
trpG; anthranilate synthase component II [EC:4.1.3.27]	0.05643	0.00365	0.06239	0.00202	0.00558	65	0.05226	0.00215	0.00481	93	0.00737	1.37492	140.389	0.17135	0.29378
ACSS, acs; acetyl-CoA synthetase [EC:6.2.1.1]	0.05624	0.00352	0.05970	0.00179	0.00524	65	0.05382	0.00208	0.00473	93	0.00706	0.83228	144.100	0.40663	0.52436
mgtC; putative Mg2+ transporter-C (MgtC) family protein	0.05618	0.00359	0.05800	0.00190	0.00541	65	0.05491	0.00214	0.00480	93	0.00723	0.42803	142.860	0.66928	0.75538
E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]	0.05600	0.00504	0.06257	0.00431	0.00814	65	0.05141	0.00380	0.00639	93	0.01035	1.07894	132.233	0.28258	0.41851
MAN; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78]	0.05576	0.00357	0.05917	0.00189	0.00539	65	0.05338	0.00211	0.00476	93	0.00720	0.80456	142.509	0.42241	0.53931
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]	0.05558	0.00359	0.05661	0.00194	0.00546	65	0.05486	0.00213	0.00479	93	0.00726	0.24106	141.957	0.80986	0.86483
djlA; DnaJ like chaperone protein	0.05523	0.00356	0.06070	0.00197	0.00550	65	0.05140	0.00201	0.00465	93	0.00720	1.29098	138.722	0.19886	0.32713
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85]	0.05514	0.00367	0.06085	0.00206	0.00563	65	0.05116	0.00215	0.00481	93	0.00740	1.30864	139.697	0.19280	0.31941
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]	0.05514	0.00367	0.06085	0.00206	0.00563	65	0.05116	0.00215	0.00481	93	0.00740	1.30864	139.697	0.19280	0.31941
cysK; cysteine synthase A [EC:2.5.1.47]	0.05500	0.00354	0.05776	0.00183	0.00531	65	0.05307	0.00210	0.00475	93	0.00712	0.65928	143.548	0.51077	0.61420
sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]	0.05466	0.00353	0.05965	0.00192	0.00544	65	0.05117	0.00200	0.00464	93	0.00715	1.18696	139.569	0.23726	0.37178
sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]	0.05466	0.00353	0.05965	0.00192	0.00544	65	0.05117	0.00200	0.00464	93	0.00715	1.18696	139.569	0.23726	0.37178
fes; enterochelin esterase and related enzymes	0.05464	0.00387	0.05728	0.00200	0.00555	65	0.05279	0.00264	0.00533	93	0.00769	0.58316	148.543	0.56067	0.66250
buk; butyrate kinase [EC:2.7.2.7]	0.05406	0.00361	0.06086	0.00196	0.00549	65	0.04930	0.00210	0.00475	93	0.00726	1.59256	140.865	0.11350	0.23153
ptb; phosphate butyryltransferase [EC:2.3.1.19]	0.05406	0.00361	0.06086	0.00196	0.00549	65	0.04930	0.00210	0.00475	93	0.00726	1.59256	140.865	0.11350	0.23153
TC.NSS; neurotransmitter:Na+ symporter, NSS family	0.05399	0.00353	0.05677	0.00188	0.00537	65	0.05205	0.00205	0.00470	93	0.00714	0.66194	141.621	0.50908	0.61377
slo; thiol-activated cytolysin	0.05287	0.00433	0.05651	0.00285	0.00662	65	0.05032	0.00306	0.00574	93	0.00876	0.70668	140.908	0.48093	0.58785
INO1, ISYNA1; myo-inositol-1-phosphate synthase [EC:5.5.1.4]	0.05261	0.00363	0.05886	0.00203	0.00558	65	0.04825	0.00210	0.00475	93	0.00733	1.44661	139.341	0.15025	0.27574
nadA; quinolinate synthase [EC:2.5.1.72]	0.05257	0.00350	0.05707	0.00190	0.00541	65	0.04942	0.00196	0.00459	93	0.00710	1.07780	139.291	0.28299	0.41851
nadB; L-aspartate oxidase [EC:1.4.3.16]	0.05257	0.00350	0.05707	0.00190	0.00541	65	0.04942	0.00196	0.00459	93	0.00710	1.07780	139.291	0.28299	0.41851
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]	0.05257	0.00350	0.05707	0.00190	0.00541	65	0.04942	0.00196	0.00459	93	0.00710	1.07780	139.291	0.28299	0.41851
dfx; superoxide reductase [EC:1.15.1.2]	0.05231	0.00350	0.05877	0.00187	0.00537	65	0.04780	0.00194	0.00457	93	0.00705	1.55480	139.461	0.12226	0.24171
sacC, levB; levanase [EC:3.2.1.65]	0.05188	0.00350	0.05577	0.00178	0.00524	65	0.04916	0.00205	0.00470	93	0.00704	0.93976	143.662	0.34892	0.46019
cidA; holin-like protein	0.05115	0.00361	0.05733	0.00196	0.00549	65	0.04682	0.00211	0.00476	93	0.00727	1.44533	141.025	0.15058	0.27591
FTCD; glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4]	0.05085	0.00351	0.05454	0.00193	0.00546	65	0.04827	0.00196	0.00459	93	0.00713	0.87947	138.406	0.38067	0.49364
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3]	0.05085	0.00351	0.05454	0.00193	0.00546	65	0.04827	0.00196	0.00459	93	0.00713	0.87947	138.406	0.38067	0.49364
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]	0.05085	0.00351	0.05454	0.00193	0.00546	65	0.04827	0.00196	0.00459	93	0.00713	0.87947	138.406	0.38067	0.49364
hutU, UROC1; urocanate hydratase [EC:4.2.1.49]	0.05085	0.00351	0.05454	0.00193	0.00546	65	0.04827	0.00196	0.00459	93	0.00713	0.87947	138.406	0.38067	0.49364
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1]	0.05054	0.00342	0.05365	0.00170	0.00511	65	0.04836	0.00197	0.00460	93	0.00687	0.76915	143.981	0.44306	0.55890
K15977; putative oxidoreductase	0.05050	0.00360	0.05682	0.00198	0.00552	65	0.04608	0.00207	0.00472	93	0.00726	1.47992	139.835	0.14114	0.26235
K07387; putative metalloprotease [EC:3.4.24.-]	0.05050	0.00345	0.05218	0.00173	0.00516	65	0.04932	0.00200	0.00464	93	0.00694	0.41246	143.867	0.68062	0.76594
ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein	0.05041	0.00349	0.05378	0.00177	0.00522	65	0.04805	0.00205	0.00469	93	0.00701	0.81580	143.927	0.41596	0.53284
mntH; manganese transport protein	0.05023	0.00350	0.05426	0.00176	0.00521	65	0.04741	0.00205	0.00470	93	0.00701	0.97632	144.081	0.33054	0.44098
hya; hyaluronoglucosaminidase [EC:3.2.1.35]	0.04989	0.00348	0.05315	0.00172	0.00514	65	0.04762	0.00205	0.00470	93	0.00697	0.79367	145.094	0.42868	0.54432
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]	0.04970	0.00346	0.05109	0.00175	0.00519	65	0.04872	0.00200	0.00464	93	0.00696	0.34073	143.377	0.73381	0.79489
ompX; outer membrane protein X	0.04961	0.00360	0.05545	0.00209	0.00567	65	0.04553	0.00201	0.00465	93	0.00733	1.35269	136.141	0.17840	0.30246
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]	0.04937	0.00342	0.05527	0.00180	0.00526	65	0.04525	0.00186	0.00447	93	0.00690	1.45093	139.408	0.14905	0.27440
K01163; uncharacterized protein	0.04905	0.00345	0.05442	0.00183	0.00530	65	0.04530	0.00190	0.00452	93	0.00697	1.30985	139.621	0.19240	0.31941
malZ; alpha-glucosidase [EC:3.2.1.20]	0.04717	0.00349	0.05176	0.00179	0.00525	65	0.04396	0.00202	0.00466	93	0.00702	1.11112	142.932	0.26838	0.40456
ldhA; D-lactate dehydrogenase [EC:1.1.1.28]	0.04713	0.00338	0.05265	0.00174	0.00518	65	0.04327	0.00184	0.00445	93	0.00682	1.37363	140.164	0.17175	0.29378
hlyIII; hemolysin III	0.04580	0.00330	0.04853	0.00156	0.00491	65	0.04389	0.00183	0.00444	93	0.00662	0.70011	144.342	0.48499	0.59055
mviM; virulence factor	0.04568	0.00336	0.04851	0.00169	0.00510	65	0.04371	0.00185	0.00446	93	0.00678	0.70906	141.762	0.47945	0.58690
umuC; DNA polymerase V	0.04530	0.00339	0.04823	0.00178	0.00524	65	0.04325	0.00185	0.00446	93	0.00688	0.72362	139.502	0.47051	0.58301
icmF; isobutyryl-CoA mutase [EC:5.4.99.13]	0.04513	0.00338	0.04691	0.00168	0.00509	65	0.04388	0.00191	0.00453	93	0.00681	0.44362	143.078	0.65799	0.75366
abgT; aminobenzoyl-glutamate transport protein	0.04510	0.00347	0.04869	0.00183	0.00530	65	0.04260	0.00196	0.00460	93	0.00702	0.86866	140.920	0.38651	0.49897
fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]	0.04465	0.00509	0.03858	0.00309	0.00690	65	0.04890	0.00478	0.00717	93	0.00995	-1.03765	152.843	0.30107	0.43744
tolA; colicin import membrane protein	0.04442	0.00335	0.04842	0.00185	0.00534	65	0.04163	0.00172	0.00431	93	0.00686	0.98914	134.705	0.32437	0.43751
cas1; CRISP-associated protein Cas1	0.04423	0.00402	0.04452	0.00250	0.00620	65	0.04402	0.00262	0.00531	93	0.00816	0.06129	139.979	0.95122	0.95867
cas2; CRISPR-associated protein Cas2	0.04423	0.00402	0.04452	0.00250	0.00620	65	0.04402	0.00262	0.00531	93	0.00816	0.06129	139.979	0.95122	0.95867
K06926; uncharacterized protein	0.04382	0.00342	0.04552	0.00170	0.00512	65	0.04263	0.00196	0.00459	93	0.00688	0.41953	143.679	0.67545	0.76087
agp; glucose-1-phosphatase [EC:3.1.3.10]	0.04356	0.00336	0.04785	0.00174	0.00518	65	0.04056	0.00182	0.00442	93	0.00681	1.07094	139.687	0.28604	0.42250
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]	0.04339	0.00329	0.04789	0.00159	0.00495	65	0.04024	0.00179	0.00439	93	0.00662	1.15500	142.778	0.25002	0.38443
glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3]	0.04339	0.00329	0.04789	0.00159	0.00495	65	0.04024	0.00179	0.00439	93	0.00662	1.15500	142.778	0.25002	0.38443
glpC; glycerol-3-phosphate dehydrogenase subunit C [EC:1.1.5.3]	0.04339	0.00329	0.04789	0.00159	0.00495	65	0.04024	0.00179	0.00439	93	0.00662	1.15500	142.778	0.25002	0.38443
kup; KUP system potassium uptake protein	0.04274	0.00347	0.04774	0.00196	0.00549	65	0.03925	0.00186	0.00447	93	0.00708	1.19788	135.474	0.23306	0.36668
panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169]	0.04170	0.00329	0.04363	0.00167	0.00507	65	0.04036	0.00176	0.00435	93	0.00668	0.48927	140.055	0.62542	0.72135
K07003; uncharacterized protein	0.04119	0.00321	0.04334	0.00157	0.00491	65	0.03968	0.00168	0.00425	93	0.00650	0.56202	140.788	0.57500	0.67667
K09975; uncharacterized protein	0.04066	0.00327	0.04356	0.00176	0.00521	65	0.03863	0.00165	0.00421	93	0.00669	0.73663	134.922	0.46263	0.57956
K08987; putative membrane protein	0.04056	0.00347	0.04815	0.00201	0.00555	65	0.03525	0.00177	0.00437	93	0.00707	1.82586	132.417	0.07012	0.23153
ABC.CD.P; putative ABC transport system permease protein	0.03931	0.00542	0.03298	0.00296	0.00675	65	0.04374	0.00580	0.00790	93	0.01039	-1.03632	155.910	0.30166	0.43751
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1]	0.03872	0.00322	0.04380	0.00168	0.00508	65	0.03518	0.00160	0.00415	93	0.00656	1.31356	135.753	0.19121	0.31853
cynT, can; carbonic anhydrase [EC:4.2.1.1]	0.03804	0.00324	0.03960	0.00166	0.00505	65	0.03694	0.00167	0.00424	93	0.00659	0.40361	138.123	0.68713	0.77177
dam; DNA adenine methylase [EC:2.1.1.72]	0.03744	0.00346	0.03763	0.00155	0.00489	65	0.03731	0.00214	0.00480	93	0.00685	0.04551	149.973	0.96376	0.96878
E3.1.6.1, aslA; arylsulfatase [EC:3.1.6.1]	0.03726	0.00323	0.03915	0.00161	0.00498	65	0.03594	0.00169	0.00426	93	0.00655	0.48966	139.740	0.62514	0.72135
fsr; MFS transporter, FSR family, fosmidomycin resistance protein	0.03587	0.00317	0.03982	0.00162	0.00500	65	0.03312	0.00157	0.00411	93	0.00647	1.03568	136.409	0.30218	0.43751
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8]	0.03516	0.00317	0.03900	0.00166	0.00506	65	0.03247	0.00154	0.00407	93	0.00649	1.00683	134.554	0.31582	0.43751
SERPINB; serpin B	0.03514	0.00314	0.03756	0.00160	0.00496	65	0.03345	0.00153	0.00406	93	0.00641	0.64122	136.079	0.52246	0.62565
K07088; uncharacterized protein	0.03455	0.00314	0.03756	0.00160	0.00496	65	0.03245	0.00154	0.00407	93	0.00642	0.79650	136.364	0.42712	0.54353
sanA; SanA protein	0.03455	0.00314	0.03756	0.00160	0.00496	65	0.03245	0.00154	0.00407	93	0.00642	0.79650	136.364	0.42712	0.54353
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17]	0.03414	0.00316	0.04023	0.00169	0.00510	65	0.02988	0.00147	0.00397	93	0.00646	1.60263	131.654	0.11141	0.23153
THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]	0.03395	0.00316	0.03978	0.00171	0.00513	65	0.02988	0.00147	0.00397	93	0.00649	1.52597	131.028	0.12943	0.24692
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-]	0.03311	0.00314	0.03724	0.00171	0.00513	65	0.03022	0.00145	0.00395	93	0.00647	1.08462	130.609	0.28009	0.41774
yjdF; putative membrane protein	0.03190	0.00301	0.03271	0.00135	0.00456	65	0.03133	0.00151	0.00402	93	0.00608	0.22834	142.339	0.81971	0.87085
capA, pgsA; gamma-polyglutamate biosynthesis protein CapA	0.03180	0.00294	0.03489	0.00138	0.00461	65	0.02964	0.00135	0.00381	93	0.00599	0.87814	136.818	0.38141	0.49398
lacA; galactoside O-acetyltransferase [EC:2.3.1.18]	0.03173	0.00303	0.03744	0.00153	0.00486	65	0.02775	0.00137	0.00384	93	0.00619	1.56367	132.962	0.12027	0.23930
lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein	0.03161	0.00299	0.03495	0.00139	0.00463	65	0.02927	0.00143	0.00392	93	0.00607	0.93501	138.904	0.35141	0.46295
higA; HTH-type transcriptional regulator / antitoxin HigA	0.03160	0.00302	0.03335	0.00142	0.00467	65	0.03037	0.00146	0.00397	93	0.00613	0.48496	139.203	0.62847	0.72415
GLPF; glycerol uptake facilitator protein	0.03061	0.00288	0.03588	0.00137	0.00459	65	0.02693	0.00125	0.00366	93	0.00587	1.52492	133.711	0.12964	0.24692
glpK, GK; glycerol kinase [EC:2.7.1.30]	0.03061	0.00288	0.03588	0.00137	0.00459	65	0.02693	0.00125	0.00366	93	0.00587	1.52492	133.711	0.12964	0.24692
RETSAT; all-trans-retinol 13,14-reductase [EC:1.3.99.23]	0.03053	0.00398	0.02711	0.00205	0.00562	65	0.03293	0.00283	0.00552	93	0.00787	-0.73918	150.001	0.46095	0.57956
K07054; uncharacterized protein	0.03010	0.00296	0.03223	0.00137	0.00459	65	0.02860	0.00140	0.00388	93	0.00601	0.60408	138.857	0.54677	0.65007
pheA2; prephenate dehydratase [EC:4.2.1.51]	0.02919	0.00297	0.02663	0.00129	0.00445	65	0.03098	0.00148	0.00399	93	0.00598	-0.72712	143.767	0.46834	0.58301
K09797; uncharacterized protein	0.02815	0.00302	0.02944	0.00150	0.00480	65	0.02725	0.00141	0.00389	93	0.00618	0.35407	135.238	0.72384	0.79489
K07729; putative transcriptional regulator	0.02704	0.00283	0.03106	0.00138	0.00461	65	0.02422	0.00117	0.00355	93	0.00582	1.17590	130.545	0.24177	0.37732
csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-]	0.02677	0.00323	0.02789	0.00154	0.00487	65	0.02598	0.00175	0.00434	93	0.00652	0.29266	143.216	0.77020	0.82583
cobN; cobaltochelatase CobN [EC:6.6.1.2]	0.02576	0.00295	0.02817	0.00146	0.00474	65	0.02407	0.00133	0.00377	93	0.00606	0.67625	133.514	0.50005	0.60634
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]	0.02567	0.00359	0.02945	0.00208	0.00566	65	0.02303	0.00201	0.00465	93	0.00732	0.87744	136.398	0.38179	0.49398
aqpZ; aquaporin Z	0.02530	0.00279	0.02755	0.00120	0.00430	65	0.02372	0.00126	0.00368	93	0.00566	0.67769	139.883	0.49909	0.60634
gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78]	0.02528	0.00409	0.02006	0.00189	0.00539	65	0.02893	0.00316	0.00583	93	0.00795	-1.11661	154.356	0.26590	0.40197
mltF; membrane-bound lytic murein transglycosylase F [EC:4.2.2.-]	0.02527	0.00282	0.02544	0.00124	0.00437	65	0.02514	0.00129	0.00372	93	0.00574	0.05243	139.354	0.95826	0.96468
SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	0.02510	0.00279	0.02643	0.00132	0.00450	65	0.02416	0.00118	0.00356	93	0.00574	0.39667	132.985	0.69225	0.77590
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]	0.02497	0.00396	0.02303	0.00204	0.00560	65	0.02633	0.00279	0.00548	93	0.00784	-0.42171	149.719	0.67384	0.75979
K06975; uncharacterized protein	0.02456	0.00308	0.02417	0.00123	0.00435	65	0.02484	0.00170	0.00427	93	0.00609	-0.10949	149.943	0.91296	0.93531
trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48]	0.02454	0.00268	0.02568	0.00114	0.00419	65	0.02375	0.00114	0.00349	93	0.00546	0.35538	137.635	0.72285	0.79489
K09117; uncharacterized protein	0.02436	0.00284	0.02433	0.00125	0.00439	65	0.02437	0.00130	0.00373	93	0.00576	-0.00719	139.295	0.99428	0.99428
znuB; zinc transport system permease protein	0.02399	0.00275	0.02390	0.00116	0.00423	65	0.02406	0.00123	0.00364	93	0.00558	-0.02940	140.293	0.97659	0.97743
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-]	0.02399	0.00275	0.02390	0.00116	0.00423	65	0.02406	0.00123	0.00364	93	0.00558	-0.02940	140.293	0.97659	0.97743
htpX; heat shock protein HtpX [EC:3.4.24.-]	0.02303	0.00278	0.02277	0.00122	0.00432	65	0.02321	0.00123	0.00364	93	0.00565	-0.07722	138.486	0.93856	0.95220
ABC.CD.TX; HlyD family secretion protein	0.02302	0.00306	0.02093	0.00109	0.00410	65	0.02448	0.00177	0.00436	93	0.00598	-0.59233	153.793	0.55450	0.65589
ABC.X2.P; putative ABC transport system permease protein	0.02250	0.00276	0.02236	0.00122	0.00433	65	0.02259	0.00121	0.00361	93	0.00564	-0.04022	137.638	0.96798	0.97218
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]	0.02233	0.00254	0.01929	0.00077	0.00345	65	0.02445	0.00119	0.00358	93	0.00497	-1.03765	152.843	0.30107	0.43744
glf; UDP-galactopyranose mutase [EC:5.4.99.9]	0.02199	0.00267	0.02439	0.00127	0.00442	65	0.02032	0.00103	0.00333	93	0.00554	0.73396	128.492	0.46431	0.58064
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	0.02176	0.00271	0.02371	0.00126	0.00439	65	0.02040	0.00110	0.00345	93	0.00558	0.59362	132.130	0.55378	0.65570
tolC; outer membrane protein	0.02171	0.00281	0.02008	0.00102	0.00396	65	0.02286	0.00142	0.00391	93	0.00556	-0.50077	150.335	0.61726	0.71337
APEX1; AP endonuclease 1 [EC:4.2.99.18]	0.02163	0.00261	0.02494	0.00115	0.00420	65	0.01932	0.00102	0.00331	93	0.00535	1.05067	132.664	0.29532	0.43125
ermC, ermA; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]	0.02163	0.00261	0.02494	0.00115	0.00420	65	0.01932	0.00102	0.00331	93	0.00535	1.05067	132.664	0.29532	0.43125
mvpA, vapC; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]	0.02163	0.00261	0.02494	0.00115	0.00420	65	0.01932	0.00102	0.00331	93	0.00535	1.05067	132.664	0.29532	0.43125
dcuA; anaerobic C4-dicarboxylate transporter DcuA	0.02135	0.00262	0.02358	0.00116	0.00422	65	0.01979	0.00103	0.00333	93	0.00538	0.70516	132.658	0.48195	0.58809
E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1]	0.02018	0.00261	0.02229	0.00125	0.00439	65	0.01871	0.00096	0.00321	93	0.00544	0.65972	125.580	0.51064	0.61420
bgaB, lacA; beta-galactosidase [EC:3.2.1.23]	0.02008	0.00252	0.02024	0.00100	0.00392	65	0.01997	0.00102	0.00331	93	0.00513	0.05169	138.838	0.95885	0.96468
K07483; transposase	0.01978	0.00253	0.02058	0.00104	0.00400	65	0.01922	0.00100	0.00327	93	0.00517	0.26321	136.017	0.79279	0.84900
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.01970	0.00260	0.02367	0.00121	0.00432	65	0.01693	0.00096	0.00321	93	0.00538	1.25193	127.301	0.21289	0.34528
ABC.CD.A; putative ABC transport system ATP-binding protein	0.01936	0.00261	0.01649	0.00074	0.00337	65	0.02137	0.00131	0.00375	93	0.00505	-0.96726	155.136	0.33492	0.44477
pepE; dipeptidase E [EC:3.4.13.21]	0.01932	0.00254	0.01907	0.00101	0.00395	65	0.01950	0.00103	0.00333	93	0.00516	-0.08239	138.690	0.93446	0.95005
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	0.01888	0.00250	0.02073	0.00113	0.00417	65	0.01759	0.00090	0.00310	93	0.00519	0.60313	127.433	0.54749	0.65025
K09805; uncharacterized protein	0.01829	0.00253	0.01790	0.00099	0.00391	65	0.01856	0.00103	0.00333	93	0.00514	-0.13035	139.369	0.89647	0.93531
E3.2.1.89; arabinogalactan endo-1,4-beta-galactosidase [EC:3.2.1.89]	0.01820	0.00245	0.01879	0.00099	0.00390	65	0.01778	0.00092	0.00315	93	0.00501	0.20214	134.941	0.84011	0.89007
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]	0.01785	0.00245	0.01761	0.00082	0.00356	65	0.01801	0.00104	0.00335	93	0.00489	-0.08342	147.339	0.93363	0.95004
NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50]	0.01686	0.00360	0.01349	0.00167	0.00507	65	0.01922	0.00232	0.00499	93	0.00712	-0.80581	150.074	0.42163	0.53890
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]	0.01663	0.00267	0.01714	0.00120	0.00429	65	0.01627	0.00109	0.00343	93	0.00549	0.15690	133.798	0.87556	0.91672
K09924; uncharacterized protein	0.01617	0.00218	0.01872	0.00081	0.00352	65	0.01439	0.00071	0.00277	93	0.00448	0.96783	132.559	0.33489	0.44477
murQ; N-acetylmuramic acid 6-phosphate etherase [EC:4.2.1.126]	0.01608	0.00236	0.01445	0.00071	0.00331	65	0.01722	0.00100	0.00327	93	0.00466	-0.59501	150.289	0.55273	0.65513
wcaJ; putative colanic acid biosysnthesis UDP-glucose lipid carrier transferase	0.01604	0.00219	0.01667	0.00073	0.00335	65	0.01561	0.00078	0.00290	93	0.00443	0.24048	140.834	0.81031	0.86483
abnA; arabinan endo-1,5-alpha-L-arabinosidase [EC:3.2.1.99]	0.01593	0.00226	0.01478	0.00071	0.00330	65	0.01673	0.00088	0.00307	93	0.00451	-0.43062	146.493	0.66737	0.75397
pspC; phage shock protein C	0.01586	0.00219	0.01622	0.00073	0.00336	65	0.01561	0.00078	0.00290	93	0.00444	0.13815	140.744	0.89032	0.93134
vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]	0.01584	0.00233	0.01620	0.00075	0.00339	65	0.01559	0.00094	0.00318	93	0.00465	0.13151	147.076	0.89556	0.93531
dapF; diaminopimelate epimerase [EC:5.1.1.7]	0.01560	0.00221	0.01611	0.00075	0.00340	65	0.01525	0.00079	0.00292	93	0.00448	0.19400	140.012	0.84646	0.89516
E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83]	0.01560	0.00221	0.01611	0.00075	0.00340	65	0.01525	0.00079	0.00292	93	0.00448	0.19400	140.012	0.84646	0.89516
fecA; Fe(3+) dicitrate transport protein	0.01536	0.00236	0.01861	0.00106	0.00405	65	0.01309	0.00075	0.00284	93	0.00494	1.11684	122.110	0.26626	0.40199
ihfA, himA; integration host factor subunit alpha	0.01532	0.00219	0.01551	0.00068	0.00323	65	0.01520	0.00082	0.00298	93	0.00439	0.07090	145.844	0.94357	0.95428
cynR; LysR family transcriptional regulator, cyn operon transcriptional activator	0.01489	0.00218	0.01699	0.00078	0.00346	65	0.01342	0.00074	0.00281	93	0.00446	0.79832	135.417	0.42608	0.54339
uxaC; glucuronate isomerase [EC:5.3.1.12]	0.01483	0.00230	0.01242	0.00060	0.00305	65	0.01650	0.00099	0.00327	93	0.00447	-0.91263	154.088	0.36286	0.47480
xylS, yicI; alpha-D-xyloside xylohydrolase [EC:3.2.1.177]	0.01481	0.00221	0.01322	0.00064	0.00314	65	0.01593	0.00087	0.00307	93	0.00439	-0.61788	149.676	0.53760	0.63981
apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	0.01464	0.00220	0.01277	0.00061	0.00306	65	0.01596	0.00088	0.00307	93	0.00434	-0.73588	151.027	0.46295	0.57956
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family	0.01464	0.00220	0.01277	0.00061	0.00306	65	0.01596	0.00088	0.00307	93	0.00434	-0.73588	151.027	0.46295	0.57956
thrC; threonine synthase [EC:4.2.3.1]	0.01464	0.00220	0.01277	0.00061	0.00306	65	0.01596	0.00088	0.00307	93	0.00434	-0.73588	151.027	0.46295	0.57956
K06872; uncharacterized protein	0.01430	0.00216	0.01699	0.00078	0.00346	65	0.01242	0.00071	0.00277	93	0.00443	1.02940	133.951	0.30515	0.43751
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73]	0.01386	0.00207	0.01199	0.00050	0.00278	65	0.01516	0.00081	0.00294	93	0.00405	-0.78373	153.588	0.43440	0.54909
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62]	0.01386	0.00207	0.01199	0.00050	0.00278	65	0.01516	0.00081	0.00294	93	0.00405	-0.78373	153.588	0.43440	0.54909
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21]	0.01386	0.00207	0.01199	0.00050	0.00278	65	0.01516	0.00081	0.00294	93	0.00405	-0.78373	153.588	0.43440	0.54909
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	0.01386	0.00207	0.01199	0.00050	0.00278	65	0.01516	0.00081	0.00294	93	0.00405	-0.78373	153.588	0.43440	0.54909
yafQ; mRNA interferase YafQ [EC:3.1.-.-]	0.01383	0.00216	0.01373	0.00071	0.00331	65	0.01390	0.00076	0.00287	93	0.00438	-0.03819	140.855	0.96959	0.97295
lctP; lactate permease	0.01364	0.00214	0.01394	0.00064	0.00313	65	0.01343	0.00079	0.00292	93	0.00428	0.12086	146.651	0.90397	0.93531
K07126; uncharacterized protein	0.01351	0.00210	0.01509	0.00069	0.00326	65	0.01240	0.00071	0.00276	93	0.00427	0.62845	139.125	0.53074	0.63425
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]	0.01342	0.00217	0.01229	0.00061	0.00306	65	0.01421	0.00084	0.00300	93	0.00429	-0.44784	149.868	0.65492	0.75088
arnE; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnE	0.01341	0.00207	0.01100	0.00049	0.00276	65	0.01509	0.00081	0.00294	93	0.00403	-1.01364	153.927	0.31234	0.43751
K07727; putative transcriptional regulator	0.01323	0.00206	0.01596	0.00077	0.00344	65	0.01133	0.00060	0.00254	93	0.00427	1.08347	126.692	0.28066	0.41774
fadL; long-chain fatty acid transport protein	0.01321	0.00206	0.01299	0.00062	0.00308	65	0.01336	0.00072	0.00278	93	0.00415	-0.08848	144.144	0.92962	0.94679
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family	0.01311	0.00203	0.01436	0.00067	0.00320	65	0.01223	0.00064	0.00263	93	0.00415	0.51422	136.271	0.60793	0.70398
cbe, mbe; cellobiose epimerase [EC:5.1.3.11]	0.01291	0.00206	0.01023	0.00048	0.00272	65	0.01478	0.00080	0.00293	93	0.00399	-1.13685	154.246	0.25737	0.39294
mgp; 4-O-beta-D-mannosyl-D-glucose phosphorylase [EC:2.4.1.281]	0.01291	0.00206	0.01023	0.00048	0.00272	65	0.01478	0.00080	0.00293	93	0.00399	-1.13685	154.246	0.25737	0.39294
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	0.01284	0.00206	0.01229	0.00061	0.00306	65	0.01323	0.00072	0.00278	93	0.00414	-0.22910	144.632	0.81912	0.87085
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6]	0.01284	0.00206	0.01229	0.00061	0.00306	65	0.01323	0.00072	0.00278	93	0.00414	-0.22910	144.632	0.81912	0.87085
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]	0.01284	0.00206	0.01229	0.00061	0.00306	65	0.01323	0.00072	0.00278	93	0.00414	-0.22910	144.632	0.81912	0.87085
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	0.01284	0.00206	0.01229	0.00061	0.00306	65	0.01323	0.00072	0.00278	93	0.00414	-0.22910	144.632	0.81912	0.87085
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69]	0.01284	0.00206	0.01231	0.00061	0.00307	65	0.01321	0.00072	0.00278	93	0.00414	-0.21610	144.380	0.82921	0.87933
xylB, XYLB; xylulokinase [EC:2.7.1.17]	0.01283	0.00206	0.01229	0.00061	0.00306	65	0.01321	0.00072	0.00278	93	0.00414	-0.22242	144.558	0.82430	0.87492
ald; alanine dehydrogenase [EC:1.4.1.1]	0.01276	0.00206	0.01200	0.00061	0.00306	65	0.01328	0.00072	0.00278	93	0.00414	-0.30938	144.568	0.75748	0.81294
abfA; alpha-N-arabinofuranosidase [EC:3.2.1.55]	0.01248	0.00207	0.01233	0.00063	0.00312	65	0.01259	0.00071	0.00276	93	0.00417	-0.06154	142.757	0.95102	0.95867
K09955; uncharacterized protein	0.01248	0.00207	0.01233	0.00063	0.00312	65	0.01259	0.00071	0.00276	93	0.00417	-0.06154	142.757	0.95102	0.95867
exuT; MFS transporter, ACS family, hexuronate transporter	0.01230	0.00205	0.01188	0.00060	0.00305	65	0.01259	0.00071	0.00276	93	0.00411	-0.17255	144.618	0.86324	0.90959
TC.SSS; solute:Na+ symporter, SSS family	0.01230	0.00205	0.01188	0.00060	0.00305	65	0.01259	0.00071	0.00276	93	0.00411	-0.17255	144.618	0.86324	0.90959
uxuA; mannonate dehydratase [EC:4.2.1.8]	0.01230	0.00205	0.01188	0.00060	0.00305	65	0.01259	0.00071	0.00276	93	0.00411	-0.17255	144.618	0.86324	0.90959
glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter	0.01209	0.00197	0.01191	0.00059	0.00302	65	0.01222	0.00064	0.00262	93	0.00400	-0.07975	140.865	0.93655	0.95133
K02477; two-component system, LytTR family, response regulator	0.01190	0.00195	0.01385	0.00063	0.00313	65	0.01054	0.00058	0.00250	93	0.00400	0.82813	133.800	0.40907	0.52634
algI; alginate O-acetyltransferase complex protein AlgI	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
dcuB; anaerobic C4-dicarboxylate transporter DcuB	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2]	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2]	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1]	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1]	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
inlA; internalin A	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
mal; methylaspartate ammonia-lyase [EC:4.3.1.2]	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15]	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
tnaA; tryptophanase [EC:4.1.99.1]	0.01172	0.00195	0.01340	0.00063	0.00312	65	0.01054	0.00058	0.00250	93	0.00400	0.71514	133.872	0.47577	0.58301
znuA; zinc transport system substrate-binding protein	0.01170	0.00207	0.01250	0.00070	0.00328	65	0.01114	0.00067	0.00268	93	0.00423	0.32142	135.836	0.74838	0.80692
terC; tellurite resistance protein TerC	0.01167	0.00191	0.01091	0.00049	0.00275	65	0.01220	0.00064	0.00262	93	0.00380	-0.34023	147.959	0.73417	0.79489
thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148]	0.01167	0.00191	0.01091	0.00049	0.00275	65	0.01220	0.00064	0.00262	93	0.00380	-0.34023	147.959	0.73417	0.79489
ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]	0.01149	0.00190	0.01046	0.00049	0.00274	65	0.01220	0.00064	0.00262	93	0.00379	-0.46052	148.209	0.64582	0.74192
araA; L-arabinose isomerase [EC:5.3.1.4]	0.01103	0.00189	0.01033	0.00048	0.00272	65	0.01151	0.00063	0.00260	93	0.00376	-0.31245	148.256	0.75514	0.81193
araD, ulaF, sgaE, sgbE; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4]	0.01103	0.00189	0.01033	0.00048	0.00272	65	0.01151	0.00063	0.00260	93	0.00376	-0.31245	148.256	0.75514	0.81193
E3.1.1.11; pectinesterase [EC:3.1.1.11]	0.01095	0.00190	0.01025	0.00050	0.00278	65	0.01144	0.00063	0.00260	93	0.00381	-0.31024	146.579	0.75682	0.81294
K07090; uncharacterized protein	0.01091	0.00194	0.01204	0.00069	0.00326	65	0.01011	0.00053	0.00238	93	0.00404	0.47733	125.481	0.63396	0.72974
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17]	0.01076	0.00188	0.00980	0.00047	0.00270	65	0.01144	0.00063	0.00260	93	0.00374	-0.43667	148.744	0.66298	0.75397
PTS-Gat-EIIC, gatC, sgcC; PTS system, galactitol-specific IIC component	0.01076	0.00188	0.00980	0.00047	0.00270	65	0.01144	0.00063	0.00260	93	0.00374	-0.43667	148.744	0.66298	0.75397
uxaA; altronate hydrolase [EC:4.2.1.7]	0.01076	0.00188	0.00980	0.00047	0.00270	65	0.01144	0.00063	0.00260	93	0.00374	-0.43667	148.744	0.66298	0.75397
uxaB; tagaturonate reductase [EC:1.1.1.58]	0.01076	0.00188	0.00980	0.00047	0.00270	65	0.01144	0.00063	0.00260	93	0.00374	-0.43667	148.744	0.66298	0.75397
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]	0.01058	0.00188	0.00935	0.00047	0.00268	65	0.01144	0.00063	0.00260	93	0.00373	-0.55924	149.063	0.57684	0.67677
K08961; chondroitin-sulfate-ABC endolyase/exolyase [EC:4.2.2.20 4.2.2.21]	0.01058	0.00188	0.00935	0.00047	0.00268	65	0.01144	0.00063	0.00260	93	0.00373	-0.55924	149.063	0.57684	0.67677
uxuB; fructuronate reductase [EC:1.1.1.57]	0.01058	0.00188	0.00935	0.00047	0.00268	65	0.01144	0.00063	0.00260	93	0.00373	-0.55924	149.063	0.57684	0.67677
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	0.00992	0.00184	0.00842	0.00041	0.00252	65	0.01097	0.00062	0.00258	93	0.00361	-0.70604	152.173	0.48124	0.58785
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	0.00979	0.00194	0.01075	0.00064	0.00313	65	0.00911	0.00057	0.00248	93	0.00399	0.40894	133.362	0.68324	0.76815
tetM, tetO; ribosomal protection tetracycline resistance protein	0.00966	0.00181	0.01075	0.00052	0.00282	65	0.00890	0.00052	0.00237	93	0.00369	0.50305	138.179	0.61573	0.71231
yoeB; toxin YoeB [EC:3.1.-.-]	0.00962	0.00198	0.01174	0.00074	0.00337	65	0.00813	0.00053	0.00240	93	0.00413	0.87300	123.201	0.38436	0.49675
E3.2.1.17; lysozyme [EC:3.2.1.17]	0.00941	0.00190	0.01247	0.00076	0.00341	65	0.00727	0.00044	0.00217	93	0.00405	1.28593	113.342	0.20109	0.32937
lolA; outer membrane lipoprotein carrier protein	0.00938	0.00176	0.00841	0.00040	0.00247	65	0.01005	0.00056	0.00245	93	0.00348	-0.47251	150.457	0.63725	0.73280
aat; leucyl/phenylalanyl-tRNA—protein transferase [EC:2.3.2.6]	0.00920	0.00191	0.01075	0.00064	0.00313	65	0.00811	0.00053	0.00240	93	0.00394	0.66885	130.040	0.50478	0.60952
clpA; ATP-dependent Clp protease ATP-binding subunit ClpA	0.00920	0.00191	0.01075	0.00064	0.00313	65	0.00811	0.00053	0.00240	93	0.00394	0.66885	130.040	0.50478	0.60952
clpS; ATP-dependent Clp protease adaptor protein ClpS	0.00920	0.00191	0.01075	0.00064	0.00313	65	0.00811	0.00053	0.00240	93	0.00394	0.66885	130.040	0.50478	0.60952
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]	0.00913	0.00190	0.01036	0.00063	0.00311	65	0.00828	0.00053	0.00240	93	0.00393	0.53015	130.380	0.59691	0.69399
troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator	0.00913	0.00190	0.01036	0.00063	0.00311	65	0.00828	0.00053	0.00240	93	0.00393	0.53015	130.380	0.59691	0.69399
cusB, silB; membrane fusion protein, Cu(I)/Ag(I) efflux system	0.00903	0.00181	0.01204	0.00070	0.00329	65	0.00693	0.00039	0.00204	93	0.00387	1.32076	111.440	0.18929	0.31584
K07504; predicted type IV restriction endonuclease	0.00901	0.00190	0.01029	0.00063	0.00312	65	0.00811	0.00053	0.00240	93	0.00393	0.55484	130.321	0.57995	0.67837
norB; nitric oxide reductase subunit B [EC:1.7.2.5]	0.00901	0.00190	0.01029	0.00063	0.00312	65	0.00811	0.00053	0.00240	93	0.00393	0.55484	130.321	0.57995	0.67837
TC.FEV.OM3, tbpA, hemR, lbpA, hpuB, bhuR, hugA, hmbR; hemoglobin/transferrin/lactoferrin receptor protein	0.00901	0.00190	0.01029	0.00063	0.00312	65	0.00811	0.00053	0.00240	93	0.00393	0.55484	130.321	0.57995	0.67837
xapB; MFS transporter, NHS family, xanthosine permease	0.00900	0.00185	0.01150	0.00070	0.00327	65	0.00725	0.00043	0.00215	93	0.00392	1.08425	116.177	0.28050	0.41774
ccrM; modification methylase [EC:2.1.1.72]	0.00865	0.00164	0.00895	0.00037	0.00238	65	0.00843	0.00047	0.00224	93	0.00327	0.15863	147.124	0.87418	0.91611
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.00865	0.00164	0.00895	0.00037	0.00238	65	0.00843	0.00047	0.00224	93	0.00327	0.15863	147.124	0.87418	0.91611
czcA; cobalt-zinc-cadmium resistance protein CzcA	0.00861	0.00205	0.01316	0.00112	0.00415	65	0.00543	0.00033	0.00190	93	0.00456	1.69534	90.794	0.09344	0.23153
gpr; L-glyceraldehyde 3-phosphate reductase [EC:1.1.1.-]	0.00848	0.00189	0.01136	0.00075	0.00341	65	0.00647	0.00043	0.00215	93	0.00403	1.21303	112.810	0.22765	0.35965
mrr; restriction system protein	0.00848	0.00177	0.00810	0.00034	0.00228	65	0.00874	0.00061	0.00257	93	0.00344	-0.18597	155.381	0.85271	0.90095
dexA; dextranase [EC:3.2.1.11]	0.00812	0.00163	0.00794	0.00041	0.00251	65	0.00825	0.00043	0.00215	93	0.00331	-0.09245	139.923	0.92648	0.94442
cusA, silA; Cu(I)/Ag(I) efflux system membrane protein CusA/SilA	0.00812	0.00172	0.01093	0.00064	0.00313	65	0.00616	0.00034	0.00192	93	0.00367	1.29734	110.472	0.19722	0.32579
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27]	0.00799	0.00175	0.01027	0.00063	0.00313	65	0.00639	0.00038	0.00202	93	0.00372	1.04137	114.832	0.29989	0.43682
penP; beta-lactamase class A [EC:3.5.2.6]	0.00787	0.00166	0.00907	0.00045	0.00263	65	0.00704	0.00043	0.00215	93	0.00339	0.59833	135.924	0.55062	0.65329
rhaA; L-rhamnose isomerase [EC:5.3.1.14]	0.00770	0.00177	0.00696	0.00043	0.00256	65	0.00822	0.00054	0.00242	93	0.00352	-0.35937	147.559	0.71983	0.79489
rhaB; rhamnulokinase [EC:2.7.1.5]	0.00770	0.00177	0.00696	0.00043	0.00256	65	0.00822	0.00054	0.00242	93	0.00352	-0.35937	147.559	0.71983	0.79489
rhaD; rhamnulose-1-phosphate aldolase [EC:4.1.2.19]	0.00770	0.00177	0.00696	0.00043	0.00256	65	0.00822	0.00054	0.00242	93	0.00352	-0.35937	147.559	0.71983	0.79489
treS; maltose alpha-D-glucosyltransferase / alpha-amylase [EC:5.4.99.16 3.2.1.1]	0.00757	0.00175	0.00722	0.00045	0.00265	65	0.00781	0.00051	0.00234	93	0.00353	-0.16853	142.677	0.86640	0.91209
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7]	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
epsD; glycosyltransferase EpsD [EC:2.4.-.-]	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
K06904; uncharacterized protein	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
K07270; glycosyl transferase, family 25	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
K09137; uncharacterized protein	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
kch, trkA, mthK, pch; voltage-gated potassium channel	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
PNC1; nicotinamidase [EC:3.5.1.19]	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
rgpB; rhamnosyltransferase [EC:2.4.1.-]	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]	0.00721	0.00170	0.00981	0.00063	0.00311	65	0.00539	0.00033	0.00190	93	0.00365	1.21337	109.783	0.22759	0.35965
E5.1.3.6; UDP-glucuronate 4-epimerase [EC:5.1.3.6]	0.00721	0.00154	0.00803	0.00034	0.00228	65	0.00663	0.00041	0.00209	93	0.00309	0.45053	145.185	0.65300	0.74943
pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44]	0.00686	0.00153	0.00807	0.00034	0.00229	65	0.00602	0.00039	0.00204	93	0.00307	0.67038	143.289	0.50369	0.60952
E2.1.1.77, pcm; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77]	0.00668	0.00152	0.00762	0.00033	0.00227	65	0.00602	0.00039	0.00204	93	0.00305	0.52542	144.020	0.60010	0.69561
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22]	0.00668	0.00152	0.00762	0.00033	0.00227	65	0.00602	0.00039	0.00204	93	0.00305	0.52542	144.020	0.60010	0.69561
UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35]	0.00668	0.00152	0.00762	0.00033	0.00227	65	0.00602	0.00039	0.00204	93	0.00305	0.52542	144.020	0.60010	0.69561
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	0.00660	0.00161	0.00516	0.00029	0.00210	65	0.00761	0.00050	0.00232	93	0.00313	-0.78302	155.009	0.43481	0.54909
aguA; alpha-glucuronidase [EC:3.2.1.139]	0.00643	0.00155	0.00541	0.00029	0.00210	65	0.00714	0.00045	0.00220	93	0.00304	-0.56833	153.222	0.57064	0.67223
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-]	0.00624	0.00155	0.00496	0.00028	0.00207	65	0.00714	0.00045	0.00220	93	0.00302	-0.72255	153.826	0.47105	0.58301
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]	0.00624	0.00155	0.00496	0.00028	0.00207	65	0.00714	0.00045	0.00220	93	0.00302	-0.72255	153.826	0.47105	0.58301
purU; formyltetrahydrofolate deformylase [EC:3.5.1.10]	0.00624	0.00155	0.00496	0.00028	0.00207	65	0.00714	0.00045	0.00220	93	0.00302	-0.72255	153.826	0.47105	0.58301
rhaT; L-rhamnose-H+ transport protein	0.00624	0.00155	0.00496	0.00028	0.00207	65	0.00714	0.00045	0.00220	93	0.00302	-0.72255	153.826	0.47105	0.58301
lplA, lplJ; lipoate—protein ligase [EC:6.3.1.20]	0.00610	0.00158	0.00418	0.00026	0.00202	65	0.00745	0.00049	0.00229	93	0.00305	-1.06859	155.534	0.28691	0.42291
K06921; uncharacterized protein	0.00569	0.00149	0.00493	0.00029	0.00212	65	0.00622	0.00039	0.00205	93	0.00295	-0.43956	148.979	0.66090	0.75397
dinD; DNA-damage-inducible protein D	0.00527	0.00125	0.00780	0.00041	0.00251	65	0.00350	0.00013	0.00118	93	0.00277	1.55358	92.553	0.12370	0.24171
MuB; ATP-dependent target DNA activator [EC:3.6.1.3]	0.00487	0.00149	0.00493	0.00035	0.00232	65	0.00483	0.00036	0.00196	93	0.00304	0.03180	138.821	0.97467	0.97721
csm1, cas10; CRISPR-associated protein Csm1	0.00480	0.00135	0.00468	0.00028	0.00207	65	0.00489	0.00030	0.00178	93	0.00273	-0.07453	140.363	0.94069	0.95220
csm2; CRISPR-associated protein Csm2	0.00480	0.00135	0.00468	0.00028	0.00207	65	0.00489	0.00030	0.00178	93	0.00273	-0.07453	140.363	0.94069	0.95220
csm3; CRISPR-associated protein Csm3	0.00480	0.00135	0.00468	0.00028	0.00207	65	0.00489	0.00030	0.00178	93	0.00273	-0.07453	140.363	0.94069	0.95220
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]	0.00371	0.00125	0.00223	0.00011	0.00130	65	0.00475	0.00034	0.00193	93	0.00232	-1.08416	150.017	0.28003	0.41774
ltaE; threonine aldolase [EC:4.1.2.48]	0.00317	0.00103	0.00407	0.00021	0.00181	65	0.00254	0.00014	0.00122	93	0.00219	0.70253	117.964	0.48373	0.58964
ABC.X2.A; putative ABC transport system ATP-binding protein	0.00307	0.00128	0.00202	0.00016	0.00159	65	0.00380	0.00033	0.00188	93	0.00246	-0.72195	155.976	0.47141	0.58301
K07454; putative restriction endonuclease	0.00307	0.00118	0.00445	0.00034	0.00230	65	0.00211	0.00013	0.00120	93	0.00260	0.90155	98.601	0.36949	0.48184
rgpA_B; gingipain R [EC:3.4.22.37]	0.00307	0.00118	0.00445	0.00034	0.00230	65	0.00211	0.00013	0.00120	93	0.00260	0.90155	98.601	0.36949	0.48184
rhaM; L-rhamnose mutarotase [EC:5.1.3.32]	0.00306	0.00121	0.00323	0.00025	0.00196	65	0.00294	0.00022	0.00154	93	0.00249	0.11617	132.356	0.90769	0.93531
agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor	0.00271	0.00100	0.00159	0.00004	0.00079	65	0.00349	0.00024	0.00161	93	0.00179	-1.06101	131.216	0.29063	0.42619
umuD; DNA polymerase V [EC:3.4.21.-]	0.00258	0.00104	0.00093	0.00002	0.00060	65	0.00373	0.00027	0.00170	93	0.00181	-1.54439	113.844	0.12527	0.24217
zraR, hydG; two-component system, NtrC family, response regulator HydG	0.00240	0.00102	0.00313	0.00023	0.00189	65	0.00188	0.00012	0.00112	93	0.00219	0.57039	107.782	0.56960	0.67169
padR; PadR family transcriptional regulator, regulatory protein PadR	0.00238	0.00093	0.00169	0.00010	0.00124	65	0.00286	0.00016	0.00132	93	0.00181	-0.64944	153.722	0.51703	0.62107
tatA; sec-independent protein translocase protein TatA	0.00220	0.00096	0.00266	0.00018	0.00167	65	0.00188	0.00012	0.00115	93	0.00203	0.38451	120.816	0.70128	0.78311
tatC; sec-independent protein translocase protein TatC	0.00220	0.00096	0.00266	0.00018	0.00167	65	0.00188	0.00012	0.00115	93	0.00203	0.38451	120.816	0.70128	0.78311
pnbA; para-nitrobenzyl esterase [EC:3.1.1.-]	0.00218	0.00096	0.00266	0.00018	0.00167	65	0.00185	0.00012	0.00115	93	0.00203	0.39833	120.827	0.69109	0.77547
ACO, acnA; aconitate hydratase [EC:4.2.1.3]	0.00208	0.00108	0.00344	0.00030	0.00214	65	0.00113	0.00011	0.00108	93	0.00239	0.96741	96.449	0.33576	0.44486
IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	0.00208	0.00108	0.00344	0.00030	0.00214	65	0.00113	0.00011	0.00108	93	0.00239	0.96741	96.449	0.33576	0.44486
argB; acetylglutamate kinase [EC:2.7.2.8]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
argE; acetylornithine deacetylase [EC:3.5.1.16]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
argF; N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
argH, ASL; argininosuccinate lyase [EC:4.3.2.1]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
cimA; (R)-citramalate synthase [EC:2.3.1.182]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
E2.6.1.11, argD; acetylornithine aminotransferase [EC:2.6.1.11]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
hisB; imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase [EC:4.2.1.19 3.1.3.15]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
hisD; histidinol dehydrogenase [EC:1.1.1.23]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
hisF; cyclase [EC:4.1.3.-]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
hisG; ATP phosphoribosyltransferase [EC:2.4.2.17]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
hisH; glutamine amidotransferase [EC:2.4.2.-]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
hisIE; phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase [EC:3.6.1.31 3.5.4.19]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]	0.00200	0.00095	0.00240	0.00018	0.00165	65	0.00172	0.00012	0.00115	93	0.00201	0.33903	121.434	0.73517	0.79489
trpA; tryptophan synthase alpha chain [EC:4.2.1.20]	0.00199	0.00095	0.00240	0.00018	0.00165	65	0.00170	0.00012	0.00115	93	0.00201	0.35299	121.442	0.72471	0.79489
trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18]	0.00199	0.00095	0.00240	0.00018	0.00165	65	0.00170	0.00012	0.00115	93	0.00201	0.35299	121.442	0.72471	0.79489
trpE; anthranilate synthase component I [EC:4.1.3.27]	0.00199	0.00095	0.00240	0.00018	0.00165	65	0.00170	0.00012	0.00115	93	0.00201	0.35299	121.442	0.72471	0.79489
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21]	0.00199	0.00095	0.00093	0.00002	0.00060	65	0.00272	0.00023	0.00156	93	0.00167	-1.06946	117.639	0.28705	0.42291
bdhAB; butanol dehydrogenase [EC:1.1.1.-]	0.00198	0.00085	0.00214	0.00011	0.00131	65	0.00186	0.00012	0.00112	93	0.00173	0.16109	139.604	0.87226	0.91575
sbcD, mre11; DNA repair protein SbcD/Mre11	0.00198	0.00085	0.00214	0.00011	0.00131	65	0.00186	0.00012	0.00112	93	0.00173	0.16109	139.604	0.87226	0.91575
TC.SULP; sulfate permease, SulP family	0.00198	0.00085	0.00214	0.00011	0.00131	65	0.00186	0.00012	0.00112	93	0.00173	0.16109	139.604	0.87226	0.91575
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.00193	0.00096	0.00370	0.00029	0.00212	65	0.00069	0.00004	0.00067	93	0.00223	1.35323	76.887	0.17995	0.30420
nosL; copper chaperone NosL	0.00182	0.00074	0.00222	0.00012	0.00133	65	0.00154	0.00007	0.00086	93	0.00159	0.43147	114.686	0.66694	0.75397
K07496; putative transposase	0.00182	0.00178	0.00434	0.00122	0.00434	65	0.00006	0.00000	0.00006	93	0.00434	0.98657	64.023	0.32757	0.43751
xylA; xylose isomerase [EC:5.3.1.5]	0.00180	0.00094	0.00195	0.00016	0.00159	65	0.00170	0.00012	0.00115	93	0.00196	0.13003	124.530	0.89675	0.93531
bshA; L-malate glycosyltransferase [EC:2.4.1.-]	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
csxA; exo-1,4-beta-D-glucosaminidase [EC:3.2.1.165]	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
E2.5.1.56, neuB; N-acetylneuraminate synthase [EC:2.5.1.56]	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
E3.5.2.10; creatinine amidohydrolase [EC:3.5.2.10]	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
FLOT; flotillin	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
higB-1; toxin HigB-1	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
K13652; AraC family transcriptional regulator	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
neuA; N-acylneuraminate cytidylyltransferase [EC:2.7.7.43]	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
RTCB, rtcB; tRNA-splicing ligase RtcB (3’-phosphate/5’-hydroxy nucleic acid ligase) [EC:6.5.1.8]	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
TC.CPA1; monovalent cation:H+ antiporter, CPA1 family	0.00180	0.00094	0.00048	0.00001	0.00040	65	0.00272	0.00023	0.00156	93	0.00161	-1.39048	104.095	0.16735	0.29098
amn; AMP nucleosidase [EC:3.2.2.4]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
coaX; type III pantothenate kinase [EC:2.7.1.33]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
cysC; adenylylsulfate kinase [EC:2.7.1.25]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
cysQ, MET22, BPNT1; 3’(2’), 5’-bisphosphate nucleotidase [EC:3.1.3.7]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
E3.1.11.5; exodeoxyribonuclease V [EC:3.1.11.5]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
EIF1, SUI1; translation initiation factor 1	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
K06973; uncharacterized protein	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
K07043; uncharacterized protein	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
K07150; uncharacterized protein	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
marC; multiple antibiotic resistance protein	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
mbtN, fadE14; acyl-ACP dehydrogenase [EC:1.3.99.-]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
mepS, spr; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
mscS; small conductance mechanosensitive channel	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
pcnB; poly(A) polymerase [EC:2.7.7.19]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
pdxB; erythronate-4-phosphate dehydrogenase [EC:1.1.1.290]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
tpx; thiol peroxidase, atypical 2-Cys peroxiredoxin [EC:1.11.1.15]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]	0.00179	0.00083	0.00169	0.00010	0.00124	65	0.00186	0.00012	0.00112	93	0.00167	-0.10473	144.116	0.91673	0.93531
eamB; cysteine/O-acetylserine efflux protein	0.00132	0.00076	0.00226	0.00016	0.00159	65	0.00067	0.00004	0.00067	93	0.00172	0.92082	86.965	0.35969	0.47172
K09124; uncharacterized protein	0.00132	0.00076	0.00226	0.00016	0.00159	65	0.00067	0.00004	0.00067	93	0.00172	0.92082	86.965	0.35969	0.47172
tagF; CDP-glycerol glycerophosphotransferase [EC:2.7.8.12]	0.00132	0.00076	0.00226	0.00016	0.00159	65	0.00067	0.00004	0.00067	93	0.00172	0.92082	86.965	0.35969	0.47172
cvrA, nhaP2; cell volume regulation protein A	0.00127	0.00090	0.00154	0.00016	0.00154	65	0.00108	0.00011	0.00108	93	0.00188	0.24678	121.612	0.80550	0.86128
hipO; hippurate hydrolase [EC:3.5.1.32]	0.00120	0.00073	0.00145	0.00014	0.00145	65	0.00102	0.00005	0.00072	93	0.00162	0.26278	95.968	0.79328	0.84900
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]	0.00099	0.00041	0.00142	0.00004	0.00080	65	0.00069	0.00002	0.00042	93	0.00090	0.80786	99.389	0.42110	0.53882
K07014; uncharacterized protein	0.00093	0.00037	0.00111	0.00003	0.00067	65	0.00080	0.00002	0.00043	93	0.00079	0.39603	114.759	0.69281	0.77590
nosD; nitrous oxidase accessory protein	0.00091	0.00037	0.00111	0.00003	0.00067	65	0.00077	0.00002	0.00043	93	0.00079	0.43147	114.686	0.66694	0.75397
nosF; Cu-processing system ATP-binding protein	0.00091	0.00037	0.00111	0.00003	0.00067	65	0.00077	0.00002	0.00043	93	0.00079	0.43147	114.686	0.66694	0.75397
nosY; Cu-processing system permease protein	0.00091	0.00037	0.00111	0.00003	0.00067	65	0.00077	0.00002	0.00043	93	0.00079	0.43147	114.686	0.66694	0.75397
nosZ; nitrous-oxide reductase [EC:1.7.2.4]	0.00091	0.00037	0.00111	0.00003	0.00067	65	0.00077	0.00002	0.00043	93	0.00079	0.43147	114.686	0.66694	0.75397
ramA; alpha-L-rhamnosidase [EC:3.2.1.40]	0.00091	0.00037	0.00111	0.00003	0.00067	65	0.00077	0.00002	0.00043	93	0.00079	0.43147	114.686	0.66694	0.75397
rnj; ribonuclease J [EC:3.1.-.-]	0.00091	0.00037	0.00111	0.00003	0.00067	65	0.00077	0.00002	0.00043	93	0.00079	0.43147	114.686	0.66694	0.75397
spsF; spore coat polysaccharide biosynthesis protein SpsF	0.00091	0.00037	0.00111	0.00003	0.00067	65	0.00077	0.00002	0.00043	93	0.00079	0.43147	114.686	0.66694	0.75397
dndD; DNA sulfur modification protein DndD	0.00079	0.00062	0.00190	0.00015	0.00151	65	0.00002	0.00000	0.00002	93	0.00151	1.24611	64.021	0.21727	0.35041
res; type III restriction enzyme [EC:3.1.21.5]	0.00078	0.00046	0.00045	0.00001	0.00045	65	0.00100	0.00005	0.00072	93	0.00085	-0.64145	145.970	0.52223	0.62565
E2.4.1.20; cellobiose phosphorylase [EC:2.4.1.20]	0.00072	0.00034	0.00086	0.00002	0.00060	65	0.00062	0.00002	0.00041	93	0.00073	0.33360	118.820	0.73927	0.79783
xylE; MFS transporter, SP family, xylose:H+ symportor	0.00072	0.00034	0.00086	0.00002	0.00060	65	0.00062	0.00002	0.00041	93	0.00073	0.33360	118.820	0.73927	0.79783
citD; citrate lyase subunit gamma (acyl carrier protein)	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34]	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10]	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
citX; holo-ACP synthase [EC:2.7.7.61]	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
dndC; DNA sulfur modification protein DndC	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
dndE; DNA sulfur modification protein DndE	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
elaA; ElaA protein	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
K02481; two-component system, NtrC family, response regulator	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
K07220; uncharacterized protein	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
K07491; putative transposase	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
kdpA; K+-transporting ATPase ATPase A chain [EC:3.6.3.12]	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
kdpB; K+-transporting ATPase ATPase B chain [EC:3.6.3.12]	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
kdpC; K+-transporting ATPase ATPase C chain [EC:3.6.3.12]	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
norB, norC; MFS transporter, DHA2 family, multidrug resistance protein	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
raxB, cvaB; ATP-binding cassette, subfamily B, bacterial RaxB	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
ribB, RIB3; 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
TC.PIT; inorganic phosphate transporter, PiT family	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
wcaK, amsJ; colanic acid/amylovoran biosynthesis protein	0.00061	0.00059	0.00145	0.00014	0.00145	65	0.00002	0.00000	0.00002	93	0.00145	0.98657	64.023	0.32757	0.43751
dnaC; DNA replication protein DnaC	0.00059	0.00043	0.00000	0.00000	0.00000	65	0.00100	0.00005	0.00072	93	0.00072	-1.38231	92.000	0.17022	0.29333
K06915; uncharacterized protein	0.00059	0.00043	0.00000	0.00000	0.00000	65	0.00100	0.00005	0.00072	93	0.00072	-1.38231	92.000	0.17022	0.29333
K07078; uncharacterized protein	0.00059	0.00043	0.00000	0.00000	0.00000	65	0.00100	0.00005	0.00072	93	0.00072	-1.38231	92.000	0.17022	0.29333
utp; urea transporter	0.00059	0.00043	0.00000	0.00000	0.00000	65	0.00100	0.00005	0.00072	93	0.00072	-1.38231	92.000	0.17022	0.29333
cytR; LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupG	0.00053	0.00029	0.00041	0.00001	0.00041	65	0.00062	0.00002	0.00041	93	0.00058	-0.36408	151.355	0.71631	0.79489
GBA, srfJ; glucosylceramidase [EC:3.2.1.45]	0.00053	0.00029	0.00041	0.00001	0.00041	65	0.00062	0.00002	0.00041	93	0.00058	-0.36408	151.355	0.71631	0.79489
K09973; uncharacterized protein	0.00053	0.00029	0.00041	0.00001	0.00041	65	0.00062	0.00002	0.00041	93	0.00058	-0.36408	151.355	0.71631	0.79489
amt, AMT, MEP; ammonium transporter, Amt family	0.00037	0.00037	0.00091	0.00005	0.00091	65	0.00000	0.00000	0.00000	93	0.00091	1.00000	64.000	0.32108	0.43751
ABC.PA.S; polar amino acid transport system substrate-binding protein	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
CS, gltA; citrate synthase [EC:2.3.3.1]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
czcB; membrane fusion protein, cobalt-zinc-cadmium efflux system	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
E3.2.1.4; endoglucanase [EC:3.2.1.4]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
E3.2.1.8, xynA; endo-1,4-beta-xylanase [EC:3.2.1.8]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
emrA; membrane fusion protein, multidrug efflux system	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
glnB; nitrogen regulatory protein P-II 1	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
gltB; glutamate synthase (NADPH/NADH) large chain [EC:1.4.1.13 1.4.1.14]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
hddA; D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
K07166; ACT domain-containing protein	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
K07484; transposase	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
K09157; uncharacterized protein	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
K09922; uncharacterized protein	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
modF; molybdate transport system ATP-binding protein	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
nhaC; Na+:H+ antiporter, NhaC family	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
pip; proline iminopeptidase [EC:3.4.11.5]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
proB; glutamate 5-kinase [EC:2.7.2.11]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
rnfA; electron transport complex protein RnfA	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
rnfC; electron transport complex protein RnfC	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
rnfD; electron transport complex protein RnfD	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
rnfE; electron transport complex protein RnfE	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
rseC; sigma-E factor negative regulatory protein RseC	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
thiG; thiazole synthase [EC:2.8.1.10]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
thiH; 2-iminoacetate synthase [EC:4.1.99.19]	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
thiS; sulfur carrier protein	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751
yaeR; glyoxylase I family protein	0.00019	0.00019	0.00045	0.00001	0.00045	65	0.00000	0.00000	0.00000	93	0.00045	1.00000	64.000	0.32108	0.43751

plot.dat <- tb.ra %>%
  arrange(desc(`Overall Mean`)) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    diff_se = SEpooled,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*diff_se,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*diff_se
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(fdr_p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.04))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.08,y = 25,
             angle=90,
             label="q-value (FDR Corrected p-value)")+
    labs(x="Mean Difference in RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p <- p1 + p2 +
  plot_annotation(title="Stratefied KO Data - Prevotella spp. (genus level only): 50 most abundant descriptions")
p

#ggsave("output/updated-figures-2021-05-20/picrust-prevo-KO.pdf",p,units="in", height=12, width=10)

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

     0      1 
 80642 102322 

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
 -7.50   -6.68   -4.88    1.25   29.69  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)    
(Intercept)    3.336      0.177   18.85   <2e-16 ***
tumor         -0.230      0.296   -0.78     0.44    
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 81.936)

    Null deviance: 8507.2  on 157  degrees of freedom
Residual deviance: 8456.6  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 6

NExt, let’s model the percent relative abundance. This will allow us to make inference about the difference average relative abundance. Which is a simpler interpretation than trying to model differences in the log relative abundance which will need to be interpreted as the multiplicative relative change.

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")

description	Est	SE	p	fdr_p
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	-0.230	0.296	0.438	0.651
aat; leucyl/phenylalanyl-tRNA—protein transferase [EC:2.3.2.6]	0.056	0.493	0.910	0.976
ABC-2.A; ABC-2 type transport system ATP-binding protein	-0.287	0.311	0.357	0.651
ABC-2.OM, wza; polysaccharide biosynthesis/export protein	-0.285	0.310	0.360	0.651
ABC-2.P; ABC-2 type transport system permease protein	-0.263	0.312	0.401	0.651
ABC-2.TX; HlyD family secretion protein	-0.249	0.304	0.415	0.651
ABC.CD.A; putative ABC transport system ATP-binding protein	-0.616	0.516	0.234	0.651
ABC.CD.P; putative ABC transport system permease protein	-0.642	0.523	0.221	0.651
ABC.CD.TX; HlyD family secretion protein	-0.566	0.561	0.314	0.651
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34]	-0.230	0.296	0.438	0.651
ABC.FEV.P; iron complex transport system permease protein	-0.230	0.296	0.438	0.651
ABC.FEV.S; iron complex transport system substrate-binding protein	-0.230	0.296	0.438	0.651
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21]	-2.168	1.874	0.249	0.651
ABC.PA.S; polar amino acid transport system substrate-binding protein	18.519	3411.091	0.996	0.998
ABC.SN.S; NitT/TauT family transport system substrate-binding protein	-0.230	0.296	0.438	0.651
ABC.X2.A; putative ABC transport system ATP-binding protein	-1.649	1.326	0.215	0.651
ABC.X2.P; putative ABC transport system permease protein	-0.521	0.433	0.230	0.651
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial	-0.288	0.314	0.360	0.651
ABCF3; ATP-binding cassette, subfamily F, member 3	-0.230	0.296	0.438	0.651
abfA; alpha-N-arabinofuranosidase [EC:3.2.1.55]	-0.691	0.615	0.263	0.651
abgT; aminobenzoyl-glutamate transport protein	-0.123	0.313	0.694	0.797
abnA; arabinan endo-1,5-alpha-L-arabinosidase [EC:3.2.1.99]	-0.573	0.507	0.260	0.651
ackA; acetate kinase [EC:2.7.2.1]	-0.230	0.296	0.438	0.651
acm; lysozyme	-0.207	0.296	0.486	0.651
ACO, acnA; aconitate hydratase [EC:4.2.1.3]	-0.429	1.387	0.758	0.843
acpP; acyl carrier protein	-0.367	0.318	0.251	0.651
acrA, mexA, adeI, smeD, mtrC, cmeA; membrane fusion protein, multidrug efflux system	-0.216	0.278	0.438	0.651
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]	-0.247	0.302	0.414	0.651
ACSS, acs; acetyl-CoA synthetase [EC:6.2.1.1]	-0.203	0.301	0.500	0.651
ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]	-0.626	0.575	0.278	0.651
adk, AK; adenylate kinase [EC:2.7.4.3]	-0.230	0.296	0.438	0.651
agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor	-0.731	0.848	0.390	0.651
agp; glucose-1-phosphatase [EC:3.1.3.10]	-0.072	0.305	0.815	0.896
aguA; alpha-glucuronidase [EC:3.2.1.139]	-0.788	0.881	0.373	0.651
aguB; N-carbamoylputrescine amidase [EC:3.5.1.53]	-0.230	0.296	0.438	0.651
ahpF; alkyl hydroperoxide reductase subunit F [EC:1.6.4.-]	-0.120	0.315	0.704	0.799
AIBP, nnrE; NAD(P)H-hydrate epimerase [EC:5.1.99.6]	-0.230	0.296	0.438	0.651
ald; alanine dehydrogenase [EC:1.4.1.1]	-0.647	0.554	0.244	0.651
algI; alginate O-acetyltransferase complex protein AlgI	-0.221	0.572	0.699	0.797
alr; alanine racemase [EC:5.1.1.1]	-0.230	0.296	0.438	0.651
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	-0.230	0.296	0.438	0.651
amn; AMP nucleosidase [EC:3.2.2.4]	-0.754	1.120	0.502	0.651
ampG; MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG	-0.211	0.297	0.479	0.651
amt, AMT, MEP; ammonium transporter, Amt family	18.212	2925.911	0.995	0.998
AMY, amyA, malS; alpha-amylase [EC:3.2.1.1]	-0.270	0.303	0.374	0.651
apbE; FAD:protein FMN transferase [EC:2.7.1.180]	-0.230	0.296	0.438	0.651
APEX1; AP endonuclease 1 [EC:4.2.99.18]	0.141	0.367	0.701	0.797
apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	-0.606	0.561	0.282	0.651
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7]	-0.230	0.296	0.438	0.651
aqpZ; aquaporin Z	0.145	0.349	0.679	0.789
araA; L-arabinose isomerase [EC:5.3.1.4]	-0.670	0.642	0.298	0.651
araD, ulaF, sgaE, sgbE; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4]	-0.670	0.642	0.298	0.651
argB; acetylglutamate kinase [EC:2.7.2.8]	-0.100	1.127	0.930	0.976
argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	-0.100	1.127	0.930	0.976
argE; acetylornithine deacetylase [EC:3.5.1.16]	-0.100	1.127	0.930	0.976
argF; N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11]	-0.100	1.127	0.930	0.976
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]	-0.100	1.127	0.930	0.976
argH, ASL; argininosuccinate lyase [EC:4.3.2.1]	-0.100	1.127	0.930	0.976
argR, ahrC; transcriptional regulator of arginine metabolism	-0.230	0.296	0.438	0.651
arnE; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnE	-0.685	0.544	0.210	0.651
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]	-0.230	0.296	0.438	0.651
AROA1, aroA; chorismate mutase [EC:5.4.99.5]	-0.230	0.296	0.438	0.651
aroB; 3-dehydroquinate synthase [EC:4.2.3.4]	-0.230	0.296	0.438	0.651
aroC; chorismate synthase [EC:4.2.3.5]	-0.230	0.296	0.438	0.651
aroE; shikimate dehydrogenase [EC:1.1.1.25]	-0.230	0.296	0.438	0.651
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	-0.230	0.296	0.438	0.651
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	-0.230	0.296	0.438	0.651
asnA; aspartate–ammonia ligase [EC:6.3.1.1]	-0.213	0.293	0.468	0.651
asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]	18.519	3411.091	0.996	0.998
asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA	-0.241	0.306	0.433	0.651
aspA; aspartate ammonia-lyase [EC:4.3.1.1]	-0.259	0.322	0.423	0.651
aspB; aspartate aminotransferase [EC:2.6.1.1]	-0.235	0.289	0.416	0.651
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]	-0.230	0.296	0.438	0.651
ATOX1, ATX1, copZ, golB; copper chaperone	-0.242	0.322	0.454	0.651
ATPF0A, atpB; F-type H+-transporting ATPase subunit a	-0.230	0.296	0.438	0.651
ATPF0B, atpF; F-type H+-transporting ATPase subunit b	-0.230	0.296	0.438	0.651
ATPF0C, atpE; F-type H+-transporting ATPase subunit c	-0.230	0.296	0.438	0.651
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]	-0.244	0.294	0.409	0.651
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]	-0.230	0.296	0.438	0.651
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta	-0.230	0.296	0.438	0.651
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon	-0.230	0.296	0.438	0.651
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma	-0.230	0.296	0.438	0.651
AXY8, FUC95A, afcA; alpha-L-fucosidase 2 [EC:3.2.1.51]	-0.161	0.278	0.562	0.689
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	-0.230	0.296	0.438	0.651
bamD; outer membrane protein assembly factor BamD	-0.230	0.296	0.438	0.651
BCP, PRXQ, DOT5; peroxiredoxin Q/BCP [EC:1.11.1.15]	-0.230	0.296	0.438	0.651
bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]	-0.309	0.308	0.317	0.651
bdhAB; butanol dehydrogenase [EC:1.1.1.-]	-0.746	1.115	0.505	0.651
bgaB, lacA; beta-galactosidase [EC:3.2.1.23]	-0.671	0.462	0.148	0.651
bglX; beta-glucosidase [EC:3.2.1.21]	-0.399	0.427	0.352	0.651
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]	-0.754	1.120	0.502	0.651
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	-0.230	0.296	0.438	0.651
BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40]	-0.224	0.296	0.452	0.651
bshA; L-malate glycosyltransferase [EC:2.4.1.-]	-2.232	1.933	0.250	0.651
buk; butyrate kinase [EC:2.7.2.7]	-0.147	0.329	0.655	0.768
capA, pgsA; gamma-polyglutamate biosynthesis protein CapA	-0.117	0.336	0.728	0.823
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]	-0.230	0.296	0.438	0.651
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]	-0.232	0.301	0.441	0.651
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]	-0.230	0.296	0.438	0.651
cas1; CRISP-associated protein Cas1	-0.588	0.445	0.188	0.651
cas2; CRISPR-associated protein Cas2	-0.588	0.445	0.188	0.651
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-]	-0.789	0.881	0.372	0.651
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]	-0.789	0.881	0.372	0.651
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]	-0.677	0.652	0.301	0.651
cbe, mbe; cellobiose epimerase [EC:5.1.3.11]	-0.588	0.587	0.318	0.651
cbpA; curved DNA-binding protein	-0.231	0.318	0.469	0.651
ccrM; modification methylase [EC:2.1.1.72]	-0.297	0.684	0.664	0.776
cdd, CDA; cytidine deaminase [EC:3.5.4.5]	-0.230	0.296	0.438	0.651
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8]	-0.230	0.296	0.438	0.651
chrA; chromate transporter	-0.220	0.299	0.463	0.651
cidA; holin-like protein	-0.110	0.293	0.709	0.803
cimA; (R)-citramalate synthase [EC:2.3.1.182]	-0.100	1.127	0.930	0.976
citD; citrate lyase subunit gamma (acyl carrier protein)	2.304	1.989	0.248	0.651
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34]	2.304	1.989	0.248	0.651
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10]	2.304	1.989	0.248	0.651
citX; holo-ACP synthase [EC:2.7.7.61]	2.304	1.989	0.248	0.651
clpA; ATP-dependent Clp protease ATP-binding subunit ClpA	0.056	0.493	0.910	0.976
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB	-0.230	0.296	0.438	0.651
clpC; ATP-dependent Clp protease ATP-binding subunit ClpC	-0.230	0.296	0.438	0.651
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]	-0.230	0.296	0.438	0.651
clpS; ATP-dependent Clp protease adaptor protein ClpS	0.056	0.493	0.910	0.976
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX	-0.230	0.296	0.438	0.651
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]	-0.230	0.296	0.438	0.651
cmk; CMP/dCMP kinase [EC:2.7.4.25]	-0.230	0.296	0.438	0.651
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5]	-0.213	0.298	0.477	0.651
coaE; dephospho-CoA kinase [EC:2.7.1.24]	-0.228	0.308	0.459	0.651
coaW; type II pantothenate kinase [EC:2.7.1.33]	-0.219	0.301	0.468	0.651
coaX; type III pantothenate kinase [EC:2.7.1.33]	-0.754	1.120	0.502	0.651
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	-0.221	0.572	0.699	0.797
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73]	-0.680	0.538	0.208	0.651
cobN; cobaltochelatase CobN [EC:6.6.1.2]	-0.341	0.419	0.416	0.651
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62]	-0.680	0.538	0.208	0.651
comEB; dCMP deaminase [EC:3.5.4.12]	-0.230	0.296	0.438	0.651
comEC; competence protein ComEC	-0.230	0.296	0.438	0.651
comM; magnesium chelatase family protein	-0.243	0.294	0.409	0.651
copB; Cu2+-exporting ATPase [EC:3.6.3.4]	-0.224	0.285	0.434	0.651
corA; magnesium transporter	-0.230	0.296	0.438	0.651
cpdB; 2’,3’-cyclic-nucleotide 2’-phosphodiesterase / 3’-nucleotidase [EC:3.1.4.16 3.1.3.6]	-0.285	0.310	0.360	0.651
crcB, FEX; fluoride exporter	-0.239	0.315	0.449	0.651
CS, gltA; citrate synthase [EC:2.3.3.1]	18.519	3411.091	0.996	0.998
csm1, cas10; CRISPR-associated protein Csm1	-1.447	1.576	0.360	0.651
csm2; CRISPR-associated protein Csm2	-1.447	1.576	0.360	0.651
csm3; CRISPR-associated protein Csm3	-1.447	1.576	0.360	0.651
csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-]	-0.460	0.462	0.321	0.651
csxA; exo-1,4-beta-D-glucosaminidase [EC:3.2.1.165]	-2.232	1.933	0.250	0.651
cusA, silA; Cu(I)/Ag(I) efflux system membrane protein CusA/SilA	0.153	0.466	0.742	0.834
cusB, silB; membrane fusion protein, Cu(I)/Ag(I) efflux system	0.045	0.522	0.932	0.976
cutC; copper homeostasis protein	-0.277	0.305	0.364	0.651
cvrA, nhaP2; cell volume regulation protein A	-1.146	1.935	0.555	0.683
cydA; cytochrome bd ubiquinol oxidase subunit I [EC:1.10.3.14]	-0.230	0.296	0.438	0.651
cydB; cytochrome bd ubiquinol oxidase subunit II [EC:1.10.3.14]	-0.230	0.296	0.438	0.651
cynR; LysR family transcriptional regulator, cyn operon transcriptional activator	-0.330	0.504	0.514	0.651
cynT, can; carbonic anhydrase [EC:4.2.1.1]	-0.169	0.333	0.614	0.731
cysC; adenylylsulfate kinase [EC:2.7.1.25]	-0.754	1.120	0.502	0.651
cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4]	-0.754	1.120	0.502	0.651
cysE; serine O-acetyltransferase [EC:2.3.1.30]	-0.157	0.290	0.590	0.717
cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10]	18.519	3411.091	0.996	0.998
cysK; cysteine synthase A [EC:2.5.1.47]	-0.260	0.313	0.407	0.651
cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4]	-0.754	1.120	0.502	0.651
cysQ, MET22, BPNT1; 3’(2’), 5’-bisphosphate nucleotidase [EC:3.1.3.7]	-0.754	1.120	0.502	0.651
cytR; LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupG	0.151	1.352	0.911	0.976
czcA; cobalt-zinc-cadmium resistance protein CzcA	0.470	0.526	0.372	0.651
czcB; membrane fusion protein, cobalt-zinc-cadmium efflux system	18.519	3411.091	0.996	0.998
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]	-0.288	0.314	0.360	0.651
dam; DNA adenine methylase [EC:2.1.1.72]	-0.174	0.353	0.623	0.740
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]	-0.230	0.296	0.438	0.651
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	-0.230	0.296	0.438	0.651
dapdh; diaminopimelate dehydrogenase [EC:1.4.1.16]	-0.228	0.293	0.436	0.651
dapF; diaminopimelate epimerase [EC:5.1.1.7]	-0.394	0.395	0.320	0.651
dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5]	-0.233	0.311	0.453	0.651
dcuA; anaerobic C4-dicarboxylate transporter DcuA	-0.318	0.477	0.505	0.651
dcuB; anaerobic C4-dicarboxylate transporter DcuB	-0.221	0.572	0.699	0.797
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]	-0.230	0.296	0.438	0.651
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13]	-0.230	0.296	0.438	0.651
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4]	-0.230	0.296	0.438	0.651
dexA; dextranase [EC:3.2.1.11]	-0.282	0.509	0.580	0.706
dfx; superoxide reductase [EC:1.15.1.2]	-0.166	0.321	0.605	0.723
dgt; dGTPase [EC:3.1.5.1]	-0.230	0.296	0.438	0.651
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]	-0.201	0.284	0.481	0.651
dinB; DNA polymerase IV [EC:2.7.7.7]	-0.230	0.296	0.438	0.651
dinD; DNA-damage-inducible protein D	-0.195	0.637	0.759	0.844
djlA; DnaJ like chaperone protein	-0.174	0.327	0.596	0.722
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]	-0.190	0.321	0.556	0.683
dnaA; chromosomal replication initiator protein	-0.230	0.296	0.438	0.651
dnaB; replicative DNA helicase [EC:3.6.4.12]	-0.230	0.296	0.438	0.651
dnaC; DNA replication protein DnaC	-17.599	3454.822	0.996	0.998
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	-0.230	0.296	0.438	0.651
dnaG; DNA primase [EC:2.7.7.-]	-0.230	0.296	0.438	0.651
dnaJ; molecular chaperone DnaJ	-0.230	0.296	0.438	0.651
dnaK, HSPA9; molecular chaperone DnaK	-0.230	0.296	0.438	0.651
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]	-0.230	0.296	0.438	0.651
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]	-0.218	0.290	0.455	0.651
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]	-0.230	0.296	0.438	0.651
dndC; DNA sulfur modification protein DndC	2.304	1.989	0.248	0.651
dndD; DNA sulfur modification protein DndD	2.332	1.962	0.236	0.651
dndE; DNA sulfur modification protein DndE	2.304	1.989	0.248	0.651
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]	-0.244	0.306	0.427	0.651
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]	18.519	3411.091	0.996	0.998
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]	-0.230	0.296	0.438	0.651
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7]	0.358	0.550	0.516	0.651
DPP3; dipeptidyl-peptidase III [EC:3.4.14.4]	-0.230	0.296	0.438	0.651
DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5]	-0.230	0.296	0.438	0.651
dps; starvation-inducible DNA-binding protein	-0.222	0.303	0.464	0.651
dsbD; thiol:disulfide interchange protein DsbD [EC:1.8.1.8]	-0.230	0.296	0.438	0.651
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]	-0.230	0.296	0.438	0.651
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]	-0.230	0.296	0.438	0.651
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]	-0.230	0.296	0.438	0.651
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	-0.211	0.305	0.489	0.651
E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]	-0.230	0.296	0.438	0.651
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	-0.178	0.295	0.546	0.680
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]	-0.123	0.286	0.667	0.778
E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4]	-0.154	0.290	0.596	0.722
E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]	-0.359	0.322	0.266	0.651
E2.1.1.77, pcm; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77]	-0.137	0.613	0.823	0.900
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	-0.234	0.306	0.446	0.651
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	-0.548	0.584	0.350	0.651
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6]	-0.548	0.584	0.350	0.651
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54]	-0.215	0.295	0.468	0.651
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8]	-0.230	0.296	0.438	0.651
E2.4.1.20; cellobiose phosphorylase [EC:2.4.1.20]	0.154	1.349	0.909	0.976
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21]	-0.680	0.538	0.208	0.651
E2.5.1.56, neuB; N-acetylneuraminate synthase [EC:2.5.1.56]	-2.232	1.933	0.250	0.651
E2.6.1.11, argD; acetylornithine aminotransferase [EC:2.6.1.11]	-0.100	1.127	0.930	0.976
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]	-0.230	0.296	0.438	0.651
E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83]	-0.394	0.395	0.320	0.651
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4]	-0.239	0.302	0.431	0.651
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71]	-0.230	0.296	0.438	0.651
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8]	-0.230	0.296	0.438	0.651
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]	-0.230	0.296	0.438	0.651
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]	-0.230	0.296	0.438	0.651
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	-0.230	0.296	0.438	0.651
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	-0.680	0.538	0.208	0.651
E3.1.1.11; pectinesterase [EC:3.1.1.11]	-0.674	0.651	0.302	0.651
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2]	-0.138	0.295	0.642	0.755
E3.1.11.5; exodeoxyribonuclease V [EC:3.1.11.5]	-0.754	1.120	0.502	0.651
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]	-0.343	0.461	0.459	0.651
E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1]	-0.400	0.466	0.392	0.651
E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48]	-0.237	0.301	0.432	0.651
E3.1.3.5; 5’-nucleotidase [EC:3.1.3.5]	-0.219	0.301	0.468	0.651
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]	-0.647	0.496	0.194	0.651
E3.1.6.1, aslA; arylsulfatase [EC:3.1.6.1]	-0.131	0.339	0.701	0.797
E3.2.1.17; lysozyme [EC:3.2.1.17]	0.038	0.447	0.932	0.976
E3.2.1.1A; alpha-amylase [EC:3.2.1.1]	-0.230	0.296	0.438	0.651
E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22]	-0.168	0.287	0.561	0.689
E3.2.1.4; endoglucanase [EC:3.2.1.4]	18.519	3411.091	0.996	0.998
E3.2.1.8, xynA; endo-1,4-beta-xylanase [EC:3.2.1.8]	18.519	3411.091	0.996	0.998
E3.2.1.89; arabinogalactan endo-1,4-beta-galactosidase [EC:3.2.1.89]	-0.483	0.529	0.363	0.651
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102]	-0.230	0.296	0.438	0.651
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	-0.260	0.336	0.441	0.651
E3.5.2.10; creatinine amidohydrolase [EC:3.5.2.10]	-2.232	1.933	0.250	0.651
E3.6.1.22, NUDT12, nudC; NAD+ diphosphatase [EC:3.6.1.22]	-0.230	0.296	0.438	0.651
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8]	-0.156	0.300	0.605	0.723
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]	-0.230	0.296	0.438	0.651
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3]	-0.206	0.295	0.486	0.651
E4.2.1.2A, fumA, fumB; fumarate hydratase, class I [EC:4.2.1.2]	-0.230	0.296	0.438	0.651
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2]	-0.221	0.572	0.699	0.797
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2]	-0.221	0.572	0.699	0.797
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]	-0.230	0.296	0.438	0.651
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17]	-0.230	0.296	0.438	0.651
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	-0.378	0.462	0.414	0.651
E5.1.3.6; UDP-glucuronate 4-epimerase [EC:5.1.3.6]	-0.057	0.574	0.921	0.976
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8]	-0.080	0.342	0.815	0.896
E6.3.5.1, NADSYN1, QNS1, nadE; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1]	-0.230	0.296	0.438	0.651
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]	-0.230	0.296	0.438	0.651
eamB; cysteine/O-acetylserine efflux protein	0.092	1.404	0.948	0.986
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]	-0.230	0.296	0.438	0.651
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]	-0.628	0.582	0.282	0.651
efp; elongation factor P	-0.230	0.296	0.438	0.651
EIF1, SUI1; translation initiation factor 1	-0.754	1.120	0.502	0.651
elaA; ElaA protein	2.304	1.989	0.248	0.651
emrA; membrane fusion protein, multidrug efflux system	18.519	3411.091	0.996	0.998
ENDOG; endonuclease G, mitochondrial	-0.199	0.305	0.515	0.651
engA, der; GTPase	-0.230	0.296	0.438	0.651
engB; GTP-binding protein	-0.230	0.296	0.438	0.651
ENO, eno; enolase [EC:4.2.1.11]	-0.230	0.296	0.438	0.651
entC; isochorismate synthase [EC:5.4.4.2]	-0.230	0.296	0.438	0.651
epsD; glycosyltransferase EpsD [EC:2.4.-.-]	0.358	0.550	0.516	0.651
eptC; heptose-I-phosphate ethanolaminephosphotransferase [EC:2.7.8.-]	-0.236	0.284	0.407	0.651
era, ERAL1; GTPase	-0.230	0.296	0.438	0.651
ermC, ermA; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]	0.141	0.367	0.701	0.797
exbB; biopolymer transport protein ExbB	-0.225	0.298	0.452	0.651
exuT; MFS transporter, ACS family, hexuronate transporter	-0.692	0.616	0.263	0.651
fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]	-0.741	0.488	0.131	0.651
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]	-0.230	0.296	0.438	0.651
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]	-0.230	0.296	0.438	0.651
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]	-0.342	0.306	0.265	0.651
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]	-0.223	0.335	0.506	0.651
fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10]	-0.219	0.301	0.468	0.651
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]	-0.741	0.488	0.131	0.651
fadL; long-chain fatty acid transport protein	-0.642	0.547	0.242	0.651
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]	-0.230	0.296	0.438	0.651
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	-0.230	0.296	0.438	0.651
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	-0.230	0.296	0.438	0.651
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11]	-0.230	0.296	0.438	0.651
fecA; Fe(3+) dicitrate transport protein	-0.202	0.360	0.576	0.703
feoB; ferrous iron transport protein B	-0.214	0.282	0.449	0.651
fes; enterochelin esterase and related enzymes	-0.206	0.316	0.516	0.651
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3]	-0.263	0.312	0.401	0.651
fic; cell filamentation protein	-0.213	0.305	0.486	0.651
fixA, etfB; electron transfer flavoprotein beta subunit	-0.230	0.296	0.438	0.651
fixB, etfA; electron transfer flavoprotein alpha subunit	-0.230	0.296	0.438	0.651
fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8]	-0.223	0.293	0.448	0.651
fldA, nifF, isiB; flavodoxin I	-0.201	0.284	0.481	0.651
FLOT; flotillin	-2.232	1.933	0.250	0.651
folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81]	-0.230	0.296	0.438	0.651
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]	-0.230	0.296	0.438	0.651
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]	-0.230	0.296	0.438	0.651
folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]	-0.240	0.304	0.431	0.651
folP; dihydropteroate synthase [EC:2.5.1.15]	-0.230	0.296	0.438	0.651
frr, MRRF, RRF; ribosome recycling factor	-0.230	0.296	0.438	0.651
fruA; fructan beta-fructosidase [EC:3.2.1.80]	-0.268	0.313	0.394	0.651
fsr; MFS transporter, FSR family, fosmidomycin resistance protein	-0.081	0.335	0.809	0.893
FTCD; glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4]	-0.162	0.333	0.626	0.741
ftnA, ftn; ferritin [EC:1.16.3.2]	-0.219	0.301	0.468	0.651
ftsA; cell division protein FtsA	-0.230	0.296	0.438	0.651
ftsE; cell division transport system ATP-binding protein	-0.230	0.296	0.438	0.651
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-]	-0.230	0.296	0.438	0.651
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]	-0.229	0.320	0.476	0.651
ftsK, spoIIIE; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family	-0.230	0.296	0.438	0.651
ftsQ; cell division protein FtsQ	-0.230	0.296	0.438	0.651
ftsW, spoVE; cell division protein FtsW	-0.230	0.296	0.438	0.651
ftsX; cell division transport system permease protein	-0.230	0.296	0.438	0.651
ftsY; fused signal recognition particle receptor	-0.230	0.296	0.438	0.651
ftsZ; cell division protein FtsZ	-0.241	0.294	0.412	0.651
FUCA; alpha-L-fucosidase [EC:3.2.1.51]	-0.246	0.300	0.413	0.651
fucP; MFS transporter, FHS family, L-fucose permease	-0.286	0.297	0.338	0.651
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator	-0.264	0.311	0.398	0.651
fusA, GFM, EFG; elongation factor G	-0.230	0.296	0.438	0.651
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]	-0.230	0.296	0.438	0.651
galK; galactokinase [EC:2.7.1.6]	-0.224	0.269	0.406	0.651
galM, GALM; aldose 1-epimerase [EC:5.1.3.3]	-0.243	0.306	0.429	0.651
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]	-0.230	0.296	0.438	0.651
GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14]	-0.230	0.296	0.438	0.651
GBA, srfJ; glucosylceramidase [EC:3.2.1.45]	0.151	1.352	0.911	0.976
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]	-0.230	0.296	0.438	0.651
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]	-0.201	0.284	0.481	0.651
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]	-0.230	0.296	0.438	0.651
gcvH, GCSH; glycine cleavage system H protein	-0.190	0.321	0.556	0.683
gcvPA; glycine dehydrogenase subunit 1 [EC:1.4.4.2]	-0.190	0.321	0.556	0.683
gcvPB; glycine dehydrogenase subunit 2 [EC:1.4.4.2]	-0.190	0.321	0.556	0.683
gcvT, AMT; aminomethyltransferase [EC:2.1.2.10]	-0.190	0.321	0.556	0.683
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]	-0.230	0.296	0.438	0.651
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme	-0.230	0.296	0.438	0.651
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	-0.230	0.296	0.438	0.651
glf; UDP-galactopyranose mutase [EC:5.4.99.9]	-0.337	0.418	0.421	0.651
glgA; starch synthase [EC:2.4.1.21]	-0.230	0.296	0.438	0.651
glk; glucokinase [EC:2.7.1.2]	-0.268	0.292	0.361	0.651
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1]	-0.221	0.572	0.699	0.797
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16]	-0.243	0.311	0.436	0.651
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1]	-0.221	0.572	0.699	0.797
glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	-0.204	0.294	0.489	0.651
glnB; nitrogen regulatory protein P-II 1	18.519	3411.091	0.996	0.998
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]	-1.045	0.919	0.257	0.651
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]	-0.228	0.331	0.492	0.651
glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3]	-0.228	0.331	0.492	0.651
glpC; glycerol-3-phosphate dehydrogenase subunit C [EC:1.1.5.3]	-0.228	0.331	0.492	0.651
GLPF; glycerol uptake facilitator protein	-0.075	0.341	0.826	0.900
glpK, GK; glycerol kinase [EC:2.7.1.30]	-0.075	0.341	0.826	0.900
glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter	-0.591	0.565	0.297	0.651
gltB; glutamate synthase (NADPH/NADH) large chain [EC:1.4.1.13 1.4.1.14]	18.519	3411.091	0.996	0.998
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14]	-0.324	0.318	0.311	0.651
glxK, garK; glycerate 2-kinase [EC:2.7.1.165]	-0.206	0.323	0.524	0.659
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]	-0.230	0.296	0.438	0.651
gmd, GMDS; GDPmannose 4,6-dehydratase [EC:4.2.1.47]	-0.230	0.296	0.438	0.651
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]	18.519	3411.091	0.996	0.998
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]	18.519	3411.091	0.996	0.998
gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78]	-0.658	0.589	0.265	0.651
gph; phosphoglycolate phosphatase [EC:3.1.3.18]	-0.223	0.280	0.427	0.651
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]	-0.230	0.296	0.438	0.651
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12]	-0.262	0.309	0.398	0.651
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	-0.249	0.316	0.432	0.651
gpr; L-glyceraldehyde 3-phosphate reductase [EC:1.1.1.-]	0.179	0.522	0.732	0.826
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]	-0.230	0.296	0.438	0.651
gpx; glutathione peroxidase [EC:1.11.1.9]	-0.203	0.301	0.502	0.651
greA; transcription elongation factor GreA	-0.248	0.296	0.404	0.651
groEL, HSPD1; chaperonin GroEL	-0.230	0.296	0.438	0.651
groES, HSPE1; chaperonin GroES	-0.230	0.296	0.438	0.651
GRPE; molecular chaperone GrpE	-0.230	0.296	0.438	0.651
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	-0.230	0.296	0.438	0.651
gyrA; DNA gyrase subunit A [EC:5.99.1.3]	-0.230	0.296	0.438	0.651
gyrB; DNA gyrase subunit B [EC:5.99.1.3]	-0.230	0.296	0.438	0.651
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]	-0.230	0.296	0.438	0.651
hcp; hydroxylamine reductase [EC:1.7.99.1]	-0.206	0.301	0.494	0.651
hddA; D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168]	18.519	3411.091	0.996	0.998
hemD, UROS; uroporphyrinogen-III synthase [EC:4.2.1.75]	-0.248	0.296	0.403	0.651
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297]	-0.230	0.296	0.438	0.651
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	-0.227	0.294	0.441	0.651
HEXA_B; hexosaminidase [EC:3.2.1.52]	-0.212	0.270	0.432	0.651
hflX; GTPase	-0.230	0.296	0.438	0.651
higA; HTH-type transcriptional regulator / antitoxin HigA	-0.106	0.353	0.765	0.849
higB-1; toxin HigB-1	-2.232	1.933	0.250	0.651
HINT1, hinT, hit; histidine triad (HIT) family protein	-0.230	0.296	0.438	0.651
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]	-0.014	0.330	0.966	0.998
hipO; hippurate hydrolase [EC:3.5.1.32]	-1.546	2.070	0.456	0.651
hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16]	-0.100	1.127	0.930	0.976
hisB; imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase [EC:4.2.1.19 3.1.3.15]	-0.100	1.127	0.930	0.976
hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]	-0.159	0.284	0.576	0.703
hisD; histidinol dehydrogenase [EC:1.1.1.23]	-0.100	1.127	0.930	0.976
hisF; cyclase [EC:4.1.3.-]	-0.100	1.127	0.930	0.976
hisG; ATP phosphoribosyltransferase [EC:2.4.2.17]	-0.100	1.127	0.930	0.976
hisH; glutamine amidotransferase [EC:2.4.2.-]	-0.100	1.127	0.930	0.976
hisIE; phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase [EC:3.6.1.31 3.5.4.19]	-0.100	1.127	0.930	0.976
hlpA, ompH; outer membrane protein	-0.230	0.296	0.438	0.651
hlyIII; hemolysin III	-0.202	0.335	0.547	0.680
holA; DNA polymerase III subunit delta [EC:2.7.7.7]	-0.230	0.296	0.438	0.651
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7]	-0.230	0.296	0.438	0.651
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1]	-0.240	0.317	0.450	0.651
hprA; glycerate dehydrogenase [EC:1.1.1.29]	-0.230	0.296	0.438	0.651
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]	-0.230	0.296	0.438	0.651
hsdM; type I restriction enzyme M protein [EC:2.1.1.72]	-0.227	0.303	0.455	0.651
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]	-0.273	0.327	0.405	0.651
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]	-0.246	0.299	0.411	0.651
hslR; ribosome-associated heat shock protein Hsp15	-0.230	0.296	0.438	0.651
HSP20; HSP20 family protein	-0.254	0.323	0.433	0.651
HSP90A, htpG; molecular chaperone HtpG	-0.230	0.296	0.438	0.651
htpX; heat shock protein HtpX [EC:3.4.24.-]	-0.446	0.424	0.294	0.651
hupB; DNA-binding protein HU-beta	-0.250	0.294	0.397	0.651
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3]	-0.162	0.333	0.626	0.741
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]	-0.162	0.333	0.626	0.741
hutU, UROC1; urocanate hydratase [EC:4.2.1.49]	-0.162	0.333	0.626	0.741
hya; hyaluronoglucosaminidase [EC:3.2.1.35]	-0.247	0.317	0.437	0.651
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	-0.220	0.308	0.477	0.651
icmF; isobutyryl-CoA mutase [EC:5.4.99.13]	-0.228	0.317	0.474	0.651
IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	-0.429	1.387	0.758	0.843
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69]	-0.542	0.584	0.355	0.651
ihfA, himA; integration host factor subunit alpha	-0.364	0.544	0.505	0.651
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]	-0.548	0.584	0.350	0.651
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	-0.548	0.584	0.350	0.651
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]	-0.230	0.296	0.438	0.651
ina; immune inhibitor A [EC:3.4.24.-]	-0.257	0.319	0.422	0.651
infA; translation initiation factor IF-1	-0.230	0.296	0.438	0.651
infB, MTIF2; translation initiation factor IF-2	-0.230	0.296	0.438	0.651
infC, MTIF3; translation initiation factor IF-3	-0.230	0.296	0.438	0.651
inlA; internalin A	-0.221	0.572	0.699	0.797
INO1, ISYNA1; myo-inositol-1-phosphate synthase [EC:5.5.1.4]	-0.144	0.334	0.667	0.778
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	-0.496	0.487	0.311	0.651
ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90]	-0.230	0.296	0.438	0.651
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]	-0.232	0.307	0.452	0.651
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]	-0.230	0.296	0.438	0.651
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]	-0.230	0.296	0.438	0.651
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4]	-0.230	0.296	0.438	0.651
K00243; uncharacterized protein	-0.230	0.296	0.438	0.651
K01163; uncharacterized protein	-0.113	0.281	0.688	0.797
K02477; two-component system, LytTR family, response regulator	-0.221	0.571	0.700	0.797
K02481; two-component system, NtrC family, response regulator	2.304	1.989	0.248	0.651
K06871; uncharacterized protein	-0.311	0.327	0.343	0.651
K06872; uncharacterized protein	-0.253	0.518	0.626	0.741
K06885; uncharacterized protein	-0.115	0.303	0.705	0.799
K06889; uncharacterized protein	-0.239	0.319	0.455	0.651
K06890; uncharacterized protein	-0.230	0.296	0.438	0.651
K06904; uncharacterized protein	0.358	0.550	0.516	0.651
K06915; uncharacterized protein	-17.599	3454.822	0.996	0.998
K06921; uncharacterized protein	-0.594	0.750	0.429	0.651
K06926; uncharacterized protein	-0.511	0.365	0.164	0.651
K06950; uncharacterized protein	-0.225	0.298	0.452	0.651
K06973; uncharacterized protein	-0.754	1.120	0.502	0.651
K06975; uncharacterized protein	-0.428	0.414	0.303	0.651
K07000; uncharacterized protein	-0.219	0.301	0.469	0.651
K07001; NTE family protein	-0.294	0.304	0.334	0.651
K07003; uncharacterized protein	-0.248	0.345	0.474	0.651
K07005; uncharacterized protein	-0.229	0.336	0.497	0.651
K07007; uncharacterized protein	-0.226	0.306	0.462	0.651
K07011; uncharacterized protein	-0.246	0.298	0.412	0.651
K07014; uncharacterized protein	-0.335	0.976	0.732	0.826
K07025; putative hydrolase of the HAD superfamily	-0.232	0.310	0.456	0.651
K07027; glycosyltransferase 2 family protein	-0.230	0.296	0.438	0.651
K07037; uncharacterized protein	-0.230	0.296	0.438	0.651
K07043; uncharacterized protein	-0.754	1.120	0.502	0.651
K07052; uncharacterized protein	-0.250	0.275	0.365	0.651
K07054; uncharacterized protein	-0.049	0.358	0.891	0.966
K07058; membrane protein	-0.229	0.309	0.461	0.651
K07078; uncharacterized protein	-17.599	3454.822	0.996	0.998
K07082; UPF0755 protein	-0.230	0.296	0.438	0.651
K07085; putative transport protein	-0.247	0.292	0.398	0.651
K07088; uncharacterized protein	-0.089	0.344	0.796	0.879
K07090; uncharacterized protein	-0.307	0.429	0.475	0.651
K07095; uncharacterized protein	-0.256	0.314	0.416	0.651
K07098; uncharacterized protein	-0.230	0.306	0.452	0.651
K07126; uncharacterized protein	-0.275	0.524	0.601	0.723
K07133; uncharacterized protein	-0.250	0.312	0.424	0.651
K07137; uncharacterized protein	-0.230	0.296	0.438	0.651
K07139; uncharacterized protein	-0.228	0.293	0.436	0.651
K07150; uncharacterized protein	-0.754	1.120	0.502	0.651
K07164; uncharacterized protein	-0.230	0.296	0.438	0.651
K07166; ACT domain-containing protein	18.519	3411.091	0.996	0.998
K07220; uncharacterized protein	2.304	1.989	0.248	0.651
K07270; glycosyl transferase, family 25	0.358	0.550	0.516	0.651
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.248	1.294	0.848	0.924
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	-0.297	0.684	0.664	0.776
K07387; putative metalloprotease [EC:3.4.24.-]	-0.247	0.316	0.435	0.651
K07454; putative restriction endonuclease	-0.001	1.049	0.999	0.999
K07481; transposase, IS5 family	-0.256	0.444	0.566	0.693
K07483; transposase	-0.398	0.499	0.426	0.651
K07484; transposase	18.519	3411.091	0.996	0.998
K07491; putative transposase	2.304	1.989	0.248	0.651
K07496; putative transposase	2.304	1.989	0.248	0.651
K07504; predicted type IV restriction endonuclease	0.054	0.493	0.913	0.976
K07727; putative transcriptional regulator	-0.211	0.577	0.715	0.809
K07729; putative transcriptional regulator	-0.054	0.371	0.885	0.961
K08303; putative protease [EC:3.4.-.-]	-0.225	0.301	0.457	0.651
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1]	-0.098	0.320	0.761	0.844
K08961; chondroitin-sulfate-ABC endolyase/exolyase [EC:4.2.2.20 4.2.2.21]	-0.677	0.652	0.301	0.651
K08987; putative membrane protein	0.038	0.353	0.913	0.976
K08998; uncharacterized protein	-0.224	0.269	0.406	0.651
K08999; uncharacterized protein	-0.216	0.297	0.468	0.651
K09117; uncharacterized protein	-0.480	0.429	0.265	0.651
K09124; uncharacterized protein	0.092	1.404	0.948	0.986
K09125; uncharacterized protein	-0.219	0.301	0.468	0.651
K09137; uncharacterized protein	0.358	0.550	0.516	0.651
K09155; uncharacterized protein	-0.226	0.296	0.445	0.651
K09157; uncharacterized protein	18.519	3411.091	0.996	0.998
K09704; uncharacterized protein	-0.223	0.285	0.435	0.651
K09797; uncharacterized protein	-0.400	0.427	0.350	0.651
K09805; uncharacterized protein	-0.659	0.562	0.243	0.651
K09861; uncharacterized protein	-0.230	0.296	0.438	0.651
K09922; uncharacterized protein	18.519	3411.091	0.996	0.998
K09924; uncharacterized protein	-0.280	0.500	0.577	0.703
K09955; uncharacterized protein	-0.691	0.615	0.263	0.651
K09973; uncharacterized protein	0.151	1.352	0.911	0.976
K09975; uncharacterized protein	-0.172	0.359	0.633	0.746
K13652; AraC family transcriptional regulator	-2.232	1.933	0.250	0.651
K15977; putative oxidoreductase	-0.050	0.281	0.859	0.934
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]	-0.230	0.296	0.438	0.651
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]	-0.230	0.296	0.438	0.651
kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29]	-0.323	0.372	0.387	0.651
kch, trkA, mthK, pch; voltage-gated potassium channel	0.358	0.550	0.516	0.651
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]	-0.577	0.590	0.329	0.651
kdpA; K+-transporting ATPase ATPase A chain [EC:3.6.3.12]	2.304	1.989	0.248	0.651
kdpB; K+-transporting ATPase ATPase B chain [EC:3.6.3.12]	2.304	1.989	0.248	0.651
kdpC; K+-transporting ATPase ATPase C chain [EC:3.6.3.12]	2.304	1.989	0.248	0.651
kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]	2.304	1.989	0.248	0.651
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]	-0.230	0.296	0.438	0.651
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]	-0.243	0.292	0.407	0.651
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]	-0.232	0.301	0.441	0.651
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13]	-0.230	0.296	0.438	0.651
kdtA, waaA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15]	-0.230	0.296	0.438	0.651
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17]	-0.676	0.652	0.302	0.651
korA, oorA, oforA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]	-0.241	0.306	0.433	0.651
korB, oorB, oforB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]	-0.241	0.306	0.433	0.651
korC, oorC; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3]	-0.230	0.296	0.438	0.651
korD, oorD; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3]	-0.230	0.296	0.438	0.651
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]	-0.230	0.296	0.438	0.651
kup; KUP system potassium uptake protein	-0.098	0.312	0.753	0.841
lacA; galactoside O-acetyltransferase [EC:2.3.1.18]	-0.062	0.367	0.865	0.940
lacI, galR; LacI family transcriptional regulator	-0.239	0.298	0.424	0.651
lacZ; beta-galactosidase [EC:3.2.1.23]	-0.222	0.291	0.446	0.651
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]	-0.222	0.299	0.458	0.651
lctP; lactate permease	-0.289	0.546	0.598	0.723
ldhA; D-lactate dehydrogenase [EC:1.1.1.28]	-0.088	0.288	0.760	0.844
lemA; LemA protein	-0.230	0.290	0.428	0.651
lepA; GTP-binding protein LepA	-0.230	0.296	0.438	0.651
lepB; signal peptidase I [EC:3.4.21.89]	-0.223	0.297	0.456	0.651
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	-0.100	1.127	0.930	0.976
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]	-0.100	1.127	0.930	0.976
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]	-0.100	1.127	0.930	0.976
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]	-0.100	1.127	0.930	0.976
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]	-0.176	0.308	0.568	0.695
lipA; lipoyl synthase [EC:2.8.1.8]	-0.230	0.317	0.469	0.651
lldE; L-lactate dehydrogenase complex protein LldE	-0.233	0.320	0.468	0.651
lldF; L-lactate dehydrogenase complex protein LldF	-0.233	0.320	0.468	0.651
lldG; L-lactate dehydrogenase complex protein LldG	-0.233	0.320	0.468	0.651
lolA; outer membrane lipoprotein carrier protein	-0.750	0.852	0.380	0.651
lolC_E; lipoprotein-releasing system permease protein	-0.230	0.296	0.438	0.651
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-]	-0.230	0.296	0.438	0.651
lon; ATP-dependent Lon protease [EC:3.4.21.53]	-0.220	0.308	0.477	0.651
lplA, lplJ; lipoate—protein ligase [EC:6.3.1.20]	-0.717	0.722	0.322	0.651
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-]	-0.230	0.296	0.438	0.651
lptF; lipopolysaccharide export system permease protein	-0.230	0.296	0.438	0.651
lptG; lipopolysaccharide export system permease protein	-0.230	0.296	0.438	0.651
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]	-0.230	0.296	0.438	0.651
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	-0.230	0.296	0.438	0.651
lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59]	-0.230	0.296	0.438	0.651
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]	-0.230	0.296	0.438	0.651
lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54]	-0.230	0.296	0.438	0.651
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130]	-0.230	0.296	0.438	0.651
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241]	-0.230	0.296	0.438	0.651
lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein	-0.042	0.347	0.904	0.976
lspA; signal peptidase II [EC:3.4.23.36]	-0.230	0.296	0.438	0.651
ltaE; threonine aldolase [EC:4.1.2.48]	-0.170	0.761	0.824	0.900
ltrA; RNA-directed DNA polymerase [EC:2.7.7.49]	2.304	1.989	0.248	0.651
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]	-0.263	0.312	0.401	0.651
LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]	-0.230	0.296	0.438	0.651
lysA; diaminopimelate decarboxylase [EC:4.1.1.20]	-0.274	0.307	0.374	0.651
lysC; aspartate kinase [EC:2.7.2.4]	-0.230	0.296	0.438	0.651
maa; maltose O-acetyltransferase [EC:2.3.1.79]	-0.230	0.328	0.484	0.651
maf; septum formation protein	-0.230	0.296	0.438	0.651
mal; methylaspartate ammonia-lyase [EC:4.3.1.2]	-0.221	0.572	0.699	0.797
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]	-0.230	0.296	0.438	0.651
malY, malT; maltose/moltooligosaccharide transporter	-0.228	0.293	0.436	0.651
malZ; alpha-glucosidase [EC:3.2.1.20]	-0.117	0.305	0.702	0.797
MAN; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78]	-0.189	0.299	0.528	0.663
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8]	-0.230	0.296	0.438	0.651
manB; phosphomannomutase [EC:5.4.2.8]	-0.230	0.296	0.438	0.651
manC, cpsB; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]	-0.230	0.296	0.438	0.651
map; methionyl aminopeptidase [EC:3.4.11.18]	-0.224	0.289	0.440	0.651
marC; multiple antibiotic resistance protein	-0.754	1.120	0.502	0.651
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	-0.230	0.296	0.438	0.651
mbtN, fadE14; acyl-ACP dehydrogenase [EC:1.3.99.-]	-0.754	1.120	0.502	0.651
mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]	0.358	0.550	0.516	0.651
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC	0.358	0.550	0.516	0.651
mdh; malate dehydrogenase [EC:1.1.1.37]	-0.230	0.296	0.438	0.651
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-]	-0.230	0.296	0.438	0.651
menB; naphthoate synthase [EC:4.1.3.36]	-0.230	0.296	0.438	0.651
menD; 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:2.2.1.9]	-0.230	0.296	0.438	0.651
menE; O-succinylbenzoic acid—CoA ligase [EC:6.2.1.26]	-0.219	0.301	0.468	0.651
mepS, spr; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13]	-0.754	1.120	0.502	0.651
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]	-0.274	0.307	0.374	0.651
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]	-0.264	0.307	0.391	0.651
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13]	-0.206	0.312	0.510	0.651
metK; S-adenosylmethionine synthetase [EC:2.5.1.6]	-0.243	0.292	0.407	0.651
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]	-0.208	0.306	0.498	0.651
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]	-0.230	0.296	0.438	0.651
mgp; 4-O-beta-D-mannosyl-D-glucose phosphorylase [EC:2.4.1.281]	-0.588	0.587	0.318	0.651
mgtC; putative Mg2+ transporter-C (MgtC) family protein	-0.280	0.308	0.365	0.651
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	-0.230	0.296	0.438	0.651
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]	-0.230	0.296	0.438	0.651
mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein	-0.230	0.296	0.438	0.651
mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein	-0.230	0.296	0.438	0.651
mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein	-0.230	0.296	0.438	0.651
mltD, dniR; membrane-bound lytic murein transglycosylase D [EC:4.2.2.-]	-0.235	0.297	0.430	0.651
mltF; membrane-bound lytic murein transglycosylase F [EC:4.2.2.-]	-0.468	0.400	0.244	0.651
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	-0.263	0.312	0.401	0.651
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]	-0.230	0.296	0.438	0.651
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	-0.230	0.296	0.438	0.651
mntH; manganese transport protein	-0.224	0.319	0.483	0.651
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22]	-0.137	0.613	0.823	0.900
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	-0.171	0.451	0.705	0.799
modF; molybdate transport system ATP-binding protein	18.519	3411.091	0.996	0.998
motB; chemotaxis protein MotB	-0.230	0.296	0.438	0.651
moxR; MoxR-like ATPase [EC:3.6.3.-]	-0.170	0.284	0.551	0.683
mp2; beta-1,4-mannooligosaccharide/beta-1,4-mannosyl-N-acetylglucosamine phosphorylase [EC:2.4.1.319 2.4.1.320]	-0.234	0.288	0.419	0.651
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]	-0.230	0.296	0.438	0.651
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	-0.230	0.296	0.438	0.651
mraZ; MraZ protein	-0.262	0.309	0.398	0.651
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4]	-0.230	0.296	0.438	0.651
mrdA; penicillin-binding protein 2 [EC:3.4.16.4]	-0.194	0.303	0.523	0.657
mreB; rod shape-determining protein MreB and related proteins	-0.230	0.296	0.438	0.651
mreC; rod shape-determining protein MreC	-0.230	0.296	0.438	0.651
mrp, NUBPL; ATP-binding protein involved in chromosome partitioning	-0.230	0.296	0.438	0.651
mrr; restriction system protein	-0.301	0.567	0.596	0.722
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-]	-0.230	0.296	0.438	0.651
mscL; large conductance mechanosensitive channel	-0.230	0.296	0.438	0.651
mscS; small conductance mechanosensitive channel	-0.754	1.120	0.502	0.651
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]	-0.230	0.296	0.438	0.651
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]	-0.230	0.296	0.438	0.651
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	-0.230	0.296	0.438	0.651
mtgA; monofunctional glycosyltransferase [EC:2.4.1.129]	-0.230	0.296	0.438	0.651
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]	-0.230	0.296	0.438	0.651
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9]	-0.230	0.296	0.438	0.651
MuB; ATP-dependent target DNA activator [EC:3.6.1.3]	-0.261	0.938	0.781	0.865
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	-0.230	0.296	0.438	0.651
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	-0.230	0.296	0.438	0.651
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8]	-0.230	0.296	0.438	0.651
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9]	-0.230	0.296	0.438	0.651
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13]	-0.230	0.296	0.438	0.651
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10]	-0.230	0.296	0.438	0.651
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]	-0.230	0.296	0.438	0.651
murI; glutamate racemase [EC:5.1.1.3]	-0.230	0.296	0.438	0.651
murQ; N-acetylmuramic acid 6-phosphate etherase [EC:4.2.1.126]	-0.747	0.519	0.152	0.651
mutL; DNA mismatch repair protein MutL	-0.230	0.296	0.438	0.651
mutS; DNA mismatch repair protein MutS	-0.230	0.296	0.438	0.651
mutS2; DNA mismatch repair protein MutS2	-0.230	0.296	0.438	0.651
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]	-0.128	0.324	0.693	0.797
mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]	-0.230	0.296	0.438	0.651
mviM; virulence factor	-0.262	0.328	0.427	0.651
mvpA, vapC; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]	0.141	0.367	0.701	0.797
nadA; quinolinate synthase [EC:2.5.1.72]	-0.172	0.328	0.602	0.723
nadB; L-aspartate oxidase [EC:1.4.3.16]	-0.172	0.328	0.602	0.723
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]	-0.172	0.328	0.602	0.723
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]	-0.230	0.296	0.438	0.651
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]	-0.226	0.290	0.438	0.651
NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50]	-0.855	0.801	0.287	0.651
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]	-0.230	0.296	0.438	0.651
ndh; NADH dehydrogenase [EC:1.6.99.3]	-0.211	0.290	0.469	0.651
ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	-0.754	1.120	0.502	0.651
NEU1; sialidase-1 [EC:3.2.1.18]	-0.234	0.288	0.419	0.651
neuA; N-acylneuraminate cytidylyltransferase [EC:2.7.7.43]	-2.232	1.933	0.250	0.651
nfrA2; FMN reductase [NAD(P)H] [EC:1.5.1.39]	-0.230	0.296	0.438	0.651
nhaA; Na+:H+ antiporter, NhaA family	-0.205	0.309	0.509	0.651
nhaC; Na+:H+ antiporter, NhaC family	18.519	3411.091	0.996	0.998
norB, norC; MFS transporter, DHA2 family, multidrug resistance protein	2.304	1.989	0.248	0.651
norB; nitric oxide reductase subunit B [EC:1.7.2.5]	0.054	0.493	0.913	0.976
nosD; nitrous oxidase accessory protein	-0.319	0.983	0.746	0.834
nosF; Cu-processing system ATP-binding protein	-0.319	0.983	0.746	0.834
nosL; copper chaperone NosL	-0.319	0.983	0.746	0.834
nosY; Cu-processing system permease protein	-0.319	0.983	0.746	0.834
nosZ; nitrous-oxide reductase [EC:1.7.2.4]	-0.319	0.983	0.746	0.834
npdA; NAD-dependent deacetylase [EC:3.5.1.-]	-0.263	0.312	0.401	0.651
nqrA; Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC:1.6.5.8]	-0.230	0.296	0.438	0.651
nqrB; Na+-transporting NADH:ubiquinone oxidoreductase subunit B [EC:1.6.5.8]	-0.230	0.296	0.438	0.651
nqrC; Na+-transporting NADH:ubiquinone oxidoreductase subunit C [EC:1.6.5.8]	-0.230	0.296	0.438	0.651
nqrD; Na+-transporting NADH:ubiquinone oxidoreductase subunit D [EC:1.6.5.8]	-0.230	0.296	0.438	0.651
nqrE; Na+-transporting NADH:ubiquinone oxidoreductase subunit E [EC:1.6.5.8]	-0.230	0.296	0.438	0.651
nqrF; Na+-transporting NADH:ubiquinone oxidoreductase subunit F [EC:1.6.5.8]	-0.230	0.296	0.438	0.651
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]	-0.230	0.296	0.438	0.651
nrfA; nitrite reductase (cytochrome c-552) [EC:1.7.2.2]	-0.217	0.299	0.469	0.651
nrfH; cytochrome c nitrite reductase small subunit	-0.217	0.299	0.469	0.651
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]	-0.230	0.296	0.438	0.651
nspC; carboxynorspermidine decarboxylase [EC:4.1.1.96]	-0.230	0.296	0.438	0.651
NTH; endonuclease III [EC:4.2.99.18]	-0.230	0.296	0.438	0.651
nuoA; NADH-quinone oxidoreductase subunit A [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nuoB; NADH-quinone oxidoreductase subunit B [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nuoH; NADH-quinone oxidoreductase subunit H [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nuoI; NADH-quinone oxidoreductase subunit I [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nuoJ; NADH-quinone oxidoreductase subunit J [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nuoK; NADH-quinone oxidoreductase subunit K [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nuoL; NADH-quinone oxidoreductase subunit L [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nuoM; NADH-quinone oxidoreductase subunit M [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nuoN; NADH-quinone oxidoreductase subunit N [EC:1.6.5.3]	-0.230	0.296	0.438	0.651
nupG; MFS transporter, NHS family, nucleoside permease	-0.230	0.296	0.438	0.651
nusA; N utilization substance protein A	-0.230	0.296	0.438	0.651
nusB; N utilization substance protein B	-0.230	0.296	0.438	0.651
nusG; transcriptional antiterminator NusG	-0.230	0.296	0.438	0.651
obgE, cgtA; GTPase [EC:3.6.5.-]	-0.230	0.296	0.438	0.651
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	-0.155	0.301	0.607	0.723
ompX; outer membrane protein X	-0.096	0.328	0.770	0.853
oprO_P; phosphate-selective porin OprO and OprP	-0.180	0.298	0.546	0.680
oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator	-0.213	0.298	0.476	0.651
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85]	-0.158	0.328	0.632	0.746
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]	-0.158	0.328	0.632	0.746
padR; PadR family transcriptional regulator, regulatory protein PadR	-1.243	1.127	0.272	0.651
panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]	-0.213	0.298	0.477	0.651
panC; pantoate–beta-alanine ligase [EC:6.3.2.1]	-0.213	0.298	0.477	0.651
panD; aspartate 1-decarboxylase [EC:4.1.1.11]	-0.213	0.298	0.477	0.651
panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169]	-0.220	0.329	0.504	0.651
parA, soj; chromosome partitioning protein	-0.290	0.310	0.351	0.651
parB, spo0J; chromosome partitioning protein, ParB family	-0.230	0.296	0.438	0.651
parC; topoisomerase IV subunit A [EC:5.99.1.-]	-0.230	0.296	0.438	0.651
parE; topoisomerase IV subunit B [EC:5.99.1.-]	-0.230	0.296	0.438	0.651
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]	-0.230	0.296	0.438	0.651
patB, malY; cystathione beta-lyase [EC:4.4.1.8]	-0.267	0.319	0.403	0.651
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease	-0.219	0.301	0.468	0.651
pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44]	-0.135	0.612	0.825	0.900
pcnB; poly(A) polymerase [EC:2.7.7.19]	-0.754	1.120	0.502	0.651
PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15]	-0.221	0.572	0.699	0.797
PDF, def; peptide deformylase [EC:3.5.1.88]	-0.230	0.296	0.438	0.651
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]	-0.230	0.296	0.438	0.651
pdxB; erythronate-4-phosphate dehydrogenase [EC:1.1.1.290]	-0.754	1.120	0.502	0.651
pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2]	-0.754	1.120	0.502	0.651
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]	-0.186	0.306	0.545	0.680
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6]	-0.219	0.301	0.468	0.651
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6]	-0.219	0.301	0.468	0.651
penP; beta-lactamase class A [EC:3.5.2.6]	-0.298	0.574	0.604	0.723
pepD; dipeptidase D [EC:3.4.13.-]	-0.230	0.296	0.438	0.651
pepE; dipeptidase E [EC:3.4.13.21]	-0.619	0.514	0.230	0.651
pepO; putative endopeptidase [EC:3.4.24.-]	-0.192	0.304	0.529	0.663
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]	-0.233	0.297	0.434	0.651
pepT; tripeptide aminopeptidase [EC:3.4.11.4]	-0.230	0.296	0.438	0.651
perR; Fur family transcriptional regulator, peroxide stress response regulator	-0.190	0.321	0.555	0.683
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]	-0.230	0.296	0.438	0.651
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4]	-0.188	0.302	0.535	0.670
pfp, PFP; diphosphate-dependent phosphofructokinase [EC:2.7.1.90]	-0.230	0.296	0.438	0.651
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]	0.038	0.480	0.937	0.977
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]	-0.230	0.296	0.438	0.651
pgm; phosphoglucomutase [EC:5.4.2.2]	-0.230	0.296	0.438	0.651
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27]	-0.015	0.569	0.979	0.998
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	-0.227	0.517	0.662	0.775
pheA2; prephenate dehydratase [EC:4.2.1.51]	-0.644	0.452	0.157	0.651
phnP; phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [EC:3.1.4.55]	-0.230	0.296	0.438	0.651
phoH, phoL; phosphate starvation-inducible protein PhoH and related proteins	-0.230	0.296	0.438	0.651
phoN; acid phosphatase (class A) [EC:3.1.3.2]	-0.073	0.305	0.811	0.894
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]	-0.230	0.296	0.438	0.651
pip; proline iminopeptidase [EC:3.4.11.5]	18.519	3411.091	0.996	0.998
PK, pyk; pyruvate kinase [EC:2.7.1.40]	-0.230	0.296	0.438	0.651
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]	-0.230	0.296	0.438	0.651
pnbA; para-nitrobenzyl esterase [EC:3.1.1.-]	-0.508	0.875	0.562	0.689
PNC1; nicotinamidase [EC:3.5.1.19]	0.358	0.550	0.516	0.651
pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-]	-0.097	0.315	0.757	0.843
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]	-0.231	0.296	0.438	0.651
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]	-0.230	0.296	0.438	0.651
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]	-0.230	0.296	0.438	0.651
pnuC; nicotinamide mononucleotide transporter	-0.230	0.296	0.438	0.651
polA; DNA polymerase I [EC:2.7.7.7]	-0.230	0.296	0.438	0.651
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]	-0.230	0.296	0.438	0.651
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]	-0.230	0.296	0.438	0.651
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]	-0.146	0.307	0.634	0.747
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]	-0.230	0.296	0.438	0.651
ppnK, NADK; NAD+ kinase [EC:2.7.1.23]	-0.230	0.296	0.438	0.651
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	-0.274	0.310	0.377	0.651
PPOX, hemY; protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15]	-0.232	0.293	0.430	0.651
pqqL; zinc protease [EC:3.4.24.-]	-0.201	0.306	0.512	0.651
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15]	-0.231	0.296	0.438	0.651
PREP; prolyl oligopeptidase [EC:3.4.21.26]	-0.210	0.327	0.521	0.656
prfA, MTRF1, MRF1; peptide chain release factor 1	-0.230	0.296	0.438	0.651
prfB; peptide chain release factor 2	-0.230	0.296	0.438	0.651
prfC; peptide chain release factor 3	-0.230	0.296	0.438	0.651
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]	-0.230	0.296	0.438	0.651
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]	-0.230	0.296	0.438	0.651
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	18.519	3411.091	0.996	0.998
proB; glutamate 5-kinase [EC:2.7.2.11]	18.519	3411.091	0.996	0.998
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]	0.139	1.250	0.912	0.976
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]	-0.230	0.296	0.438	0.651
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]	-0.230	0.296	0.438	0.651
pspC; phage shock protein C	-0.429	0.536	0.424	0.651
pstS; phosphate transport system substrate-binding protein	-0.230	0.296	0.438	0.651
ptb; phosphate butyryltransferase [EC:2.3.1.19]	-0.147	0.329	0.655	0.768
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	-0.230	0.296	0.438	0.651
PTS-Gat-EIIC, gatC, sgcC; PTS system, galactitol-specific IIC component	-0.676	0.652	0.302	0.651
pulA; pullulanase [EC:3.2.1.41]	-0.252	0.318	0.429	0.651
punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1]	-0.230	0.296	0.438	0.651
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]	-0.230	0.296	0.438	0.651
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2]	-0.230	0.296	0.438	0.651
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]	-0.230	0.296	0.438	0.651
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13]	-0.230	0.296	0.438	0.651
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]	-0.230	0.296	0.438	0.651
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	-0.219	0.308	0.477	0.651
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]	-0.230	0.296	0.438	0.651
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]	-0.220	0.308	0.477	0.651
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]	-0.230	0.296	0.438	0.651
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]	-0.360	0.503	0.475	0.651
purT; phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2]	-0.193	0.294	0.513	0.651
purU; formyltetrahydrofolate deformylase [EC:3.5.1.10]	-0.789	0.881	0.372	0.651
pycB; pyruvate carboxylase subunit B [EC:6.4.1.1]	-0.230	0.296	0.438	0.651
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	-0.230	0.296	0.438	0.651
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]	-0.230	0.296	0.438	0.651
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]	-0.230	0.296	0.438	0.651
pyrDII; dihydroorotate dehydrogenase electron transfer subunit	-0.230	0.296	0.438	0.651
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]	-0.230	0.296	0.438	0.651
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23]	-0.230	0.296	0.438	0.651
pyrG, CTPS; CTP synthase [EC:6.3.4.2]	-0.230	0.296	0.438	0.651
pyrH; uridylate kinase [EC:2.7.4.22]	-0.230	0.296	0.438	0.651
pyrI; aspartate carbamoyltransferase regulatory subunit	-0.230	0.296	0.438	0.651
pyrP, uraA; uracil permease	-0.217	0.297	0.467	0.651
QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18]	-0.230	0.296	0.438	0.651
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]	-0.225	0.301	0.457	0.651
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	-0.230	0.296	0.438	0.651
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	-0.395	0.451	0.383	0.651
queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]	-0.230	0.296	0.438	0.651
queG; epoxyqueuosine reductase [EC:1.17.99.6]	-0.230	0.296	0.438	0.651
radA, sms; DNA repair protein RadA/Sms	-0.284	0.308	0.358	0.651
radC; DNA repair protein RadC	-0.230	0.296	0.438	0.651
ramA; alpha-L-rhamnosidase [EC:3.2.1.40]	-0.319	0.983	0.746	0.834
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]	-0.230	0.296	0.438	0.651
raxB, cvaB; ATP-binding cassette, subfamily B, bacterial RaxB	2.304	1.989	0.248	0.651
rbfA; ribosome-binding factor A	-0.230	0.296	0.438	0.651
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]	-0.230	0.296	0.438	0.651
recA; recombination protein RecA	-0.230	0.296	0.438	0.651
recF; DNA replication and repair protein RecF	-0.230	0.296	0.438	0.651
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]	-0.213	0.312	0.495	0.651
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]	-0.230	0.296	0.438	0.651
recN; DNA repair protein RecN (Recombination protein N)	-0.230	0.296	0.438	0.651
recO; DNA repair protein RecO (recombination protein O)	-0.230	0.296	0.438	0.651
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12]	-0.243	0.293	0.409	0.651
recR; recombination protein RecR	-0.230	0.296	0.438	0.651
recX; regulatory protein	-0.230	0.296	0.438	0.651
relA; GTP pyrophosphokinase [EC:2.7.6.5]	-0.231	0.299	0.439	0.651
RENBP; N-acylglucosamine 2-epimerase [EC:5.1.3.8]	-0.240	0.289	0.409	0.651
res; type III restriction enzyme [EC:3.1.21.5]	-5.080	10.936	0.643	0.756
RETSAT; all-trans-retinol 13,14-reductase [EC:1.3.99.23]	-0.696	0.523	0.185	0.651
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]	-0.230	0.296	0.438	0.651
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]	-0.230	0.296	0.438	0.651
rgpA_B; gingipain R [EC:3.4.22.37]	-0.001	1.049	0.999	0.999
rgpB; rhamnosyltransferase [EC:2.4.1.-]	0.358	0.550	0.516	0.651
rhaA; L-rhamnose isomerase [EC:5.3.1.14]	-0.810	0.830	0.330	0.651
rhaB; rhamnulokinase [EC:2.7.1.5]	-0.810	0.830	0.330	0.651
rhaD; rhamnulose-1-phosphate aldolase [EC:4.1.2.19]	-0.810	0.830	0.330	0.651
rhaM; L-rhamnose mutarotase [EC:5.1.3.32]	-0.846	0.965	0.382	0.651
rhaT; L-rhamnose-H+ transport protein	-0.789	0.881	0.372	0.651
rho; transcription termination factor Rho	-0.230	0.296	0.438	0.651
ribB, RIB3; 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]	2.304	1.989	0.248	0.651
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]	-0.231	0.296	0.437	0.651
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]	-0.230	0.296	0.438	0.651
ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	-0.230	0.296	0.438	0.651
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]	-0.230	0.296	0.438	0.651
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]	-0.230	0.296	0.438	0.651
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]	-0.230	0.296	0.438	0.651
rimM; 16S rRNA processing protein RimM	-0.230	0.296	0.438	0.651
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	-0.230	0.296	0.438	0.651
rimP; ribosome maturation factor RimP	-0.230	0.296	0.438	0.651
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]	-0.230	0.296	0.438	0.651
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]	-0.230	0.296	0.438	0.651
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]	-0.230	0.296	0.438	0.651
rlpA; rare lipoprotein A	-0.217	0.299	0.469	0.651
rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]	-0.223	0.336	0.508	0.651
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]	-0.230	0.296	0.438	0.651
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]	-0.230	0.296	0.438	0.651
rmuC; DNA recombination protein RmuC	-0.230	0.296	0.438	0.651
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]	-0.217	0.299	0.469	0.651
rnfA; electron transport complex protein RnfA	18.519	3411.091	0.996	0.998
rnfC; electron transport complex protein RnfC	18.519	3411.091	0.996	0.998
rnfD; electron transport complex protein RnfD	18.519	3411.091	0.996	0.998
rnfE; electron transport complex protein RnfE	18.519	3411.091	0.996	0.998
rnfG; electron transport complex protein RnfG	-0.222	0.324	0.494	0.651
rng, cafA; ribonuclease G [EC:3.1.26.-]	-0.230	0.296	0.438	0.651
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]	-0.230	0.296	0.438	0.651
rnhB; ribonuclease HII [EC:3.1.26.4]	-0.230	0.296	0.438	0.651
rnj; ribonuclease J [EC:3.1.-.-]	-0.319	0.983	0.746	0.834
rnpA; ribonuclease P protein component [EC:3.1.26.5]	-0.230	0.296	0.438	0.651
rnr, vacB; ribonuclease R [EC:3.1.-.-]	-0.230	0.296	0.438	0.651
rny; ribonucrease Y [EC:3.1.-.-]	-0.230	0.296	0.438	0.651
rnz; ribonuclease Z [EC:3.1.26.11]	-0.230	0.296	0.438	0.651
rodA, mrdB; rod shape determining protein RodA	-0.230	0.296	0.438	0.651
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	-0.230	0.296	0.438	0.651
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10	-0.230	0.296	0.438	0.651
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11	-0.230	0.296	0.438	0.651
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13	-0.230	0.296	0.438	0.651
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	-0.230	0.296	0.438	0.651
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15	-0.230	0.296	0.438	0.651
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	-0.230	0.296	0.438	0.651
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17	-0.201	0.284	0.481	0.651
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18	-0.230	0.296	0.438	0.651
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19	-0.230	0.296	0.438	0.651
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2	-0.230	0.296	0.438	0.651
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20	-0.230	0.296	0.438	0.651
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	-0.230	0.296	0.438	0.651
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22	-0.230	0.296	0.438	0.651
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23	-0.230	0.296	0.438	0.651
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24	-0.230	0.296	0.438	0.651
RP-L25, rplY; large subunit ribosomal protein L25	-0.230	0.296	0.438	0.651
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27	-0.230	0.296	0.438	0.651
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28	-0.230	0.296	0.438	0.651
RP-L29, rpmC; large subunit ribosomal protein L29	-0.230	0.296	0.438	0.651
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	-0.230	0.296	0.438	0.651
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30	-0.230	0.296	0.438	0.651
RP-L31, rpmE; large subunit ribosomal protein L31	-0.230	0.296	0.438	0.651
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32	-0.230	0.296	0.438	0.651
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33	-0.230	0.296	0.438	0.651
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34	-0.228	0.293	0.436	0.651
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35	-0.230	0.296	0.438	0.651
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36	-0.123	0.303	0.685	0.796
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4	-0.230	0.296	0.438	0.651
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	-0.230	0.296	0.438	0.651
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6	-0.230	0.296	0.438	0.651
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12	-0.230	0.296	0.438	0.651
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9	-0.230	0.296	0.438	0.651
RP-S1, rpsA; small subunit ribosomal protein S1	-0.230	0.296	0.438	0.651
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10	-0.230	0.296	0.438	0.651
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11	-0.230	0.296	0.438	0.651
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	-0.230	0.296	0.438	0.651
RP-S13, rpsM; small subunit ribosomal protein S13	-0.230	0.296	0.438	0.651
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14	-0.230	0.296	0.438	0.651
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15	-0.230	0.296	0.438	0.651
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16	-0.230	0.296	0.438	0.651
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17	-0.230	0.296	0.438	0.651
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18	-0.230	0.296	0.438	0.651
RP-S19, rpsS; small subunit ribosomal protein S19	-0.230	0.296	0.438	0.651
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	-0.230	0.296	0.438	0.651
RP-S20, rpsT; small subunit ribosomal protein S20	-0.230	0.296	0.438	0.651
RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21	-0.230	0.296	0.438	0.651
RP-S3, rpsC; small subunit ribosomal protein S3	-0.230	0.296	0.438	0.651
RP-S4, rpsD; small subunit ribosomal protein S4	-0.230	0.296	0.438	0.651
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5	-0.230	0.296	0.438	0.651
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	-0.230	0.296	0.438	0.651
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7	-0.230	0.296	0.438	0.651
RP-S8, rpsH; small subunit ribosomal protein S8	-0.230	0.296	0.438	0.651
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9	-0.230	0.296	0.438	0.651
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1]	-0.230	0.296	0.438	0.651
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]	-0.230	0.296	0.438	0.651
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]	-0.220	0.308	0.477	0.651
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]	-0.230	0.296	0.438	0.651
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6]	-0.230	0.296	0.438	0.651
rpoD; RNA polymerase primary sigma factor	-0.226	0.304	0.458	0.651
rpoE; RNA polymerase sigma-70 factor, ECF subfamily	-0.274	0.308	0.375	0.651
rpoN; RNA polymerase sigma-54 factor	-0.230	0.296	0.438	0.651
rseC; sigma-E factor negative regulatory protein RseC	18.519	3411.091	0.996	0.998
rseP; regulator of sigma E protease [EC:3.4.24.-]	-0.230	0.296	0.438	0.651
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	-0.230	0.296	0.438	0.651
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]	-0.230	0.296	0.438	0.651
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198]	-0.242	0.294	0.412	0.651
RTCB, rtcB; tRNA-splicing ligase RtcB (3’-phosphate/5’-hydroxy nucleic acid ligase) [EC:6.5.1.8]	-2.232	1.933	0.250	0.651
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2]	-0.230	0.296	0.438	0.651
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]	-0.230	0.296	0.438	0.651
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]	-0.230	0.296	0.438	0.651
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]	-0.230	0.296	0.438	0.651
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]	-0.230	0.296	0.438	0.651
ruvX; putative holliday junction resolvase [EC:3.1.-.-]	-0.230	0.296	0.438	0.651
sacC, levB; levanase [EC:3.2.1.65]	-0.223	0.321	0.489	0.651
SAM50, TOB55, bamA; outer membrane protein insertion porin family	-0.230	0.296	0.438	0.651
sanA; SanA protein	-0.089	0.344	0.796	0.879
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]	-0.230	0.296	0.438	0.651
sbcD, mre11; DNA repair protein SbcD/Mre11	-0.746	1.115	0.505	0.651
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4]	-0.230	0.296	0.438	0.651
sdhB, frdB; succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.1 1.3.5.4]	-0.230	0.296	0.438	0.651
sdhC, frdC; succinate dehydrogenase / fumarate reductase, cytochrome b subunit	-0.230	0.296	0.438	0.651
secA; preprotein translocase subunit SecA	-0.230	0.296	0.438	0.651
secDF; SecD/SecF fusion protein	-0.230	0.296	0.438	0.651
secE; preprotein translocase subunit SecE	-0.216	0.300	0.472	0.651
secG; preprotein translocase subunit SecG	-0.230	0.296	0.438	0.651
secY; preprotein translocase subunit SecY	-0.230	0.296	0.438	0.651
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]	-0.228	0.293	0.436	0.651
serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3]	-0.237	0.319	0.459	0.651
serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52]	-0.228	0.293	0.436	0.651
SERPINB; serpin B	-0.131	0.338	0.699	0.797
SIAE; sialate O-acetylesterase [EC:3.1.1.53]	-0.283	0.313	0.368	0.651
SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5	-0.208	0.313	0.507	0.651
slo; thiol-activated cytolysin	-0.154	0.385	0.690	0.797
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]	-0.230	0.296	0.438	0.651
smf; DNA processing protein	-0.230	0.296	0.438	0.651
smpB; SsrA-binding protein	-0.230	0.296	0.438	0.651
SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	-0.396	0.395	0.317	0.651
speA; arginine decarboxylase [EC:4.1.1.19]	-0.230	0.296	0.438	0.651
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]	-0.230	0.296	0.438	0.651
spoU; RNA methyltransferase, TrmH family	-0.230	0.296	0.438	0.651
SPP; sucrose-6-phosphatase [EC:3.1.3.24]	-0.208	0.288	0.471	0.651
sppA; protease IV [EC:3.4.21.-]	-0.230	0.296	0.438	0.651
spsF; spore coat polysaccharide biosynthesis protein SpsF	-0.319	0.983	0.746	0.834
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]	-0.230	0.296	0.438	0.651
ssb; single-strand DNA-binding protein	-0.232	0.301	0.441	0.651
sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5]	-0.173	0.329	0.600	0.723
sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]	-0.173	0.329	0.600	0.723
sufB; Fe-S cluster assembly protein SufB	-0.230	0.296	0.438	0.651
sufC; Fe-S cluster assembly ATP-binding protein	-0.230	0.296	0.438	0.651
sufD; Fe-S cluster assembly protein SufD	-0.230	0.296	0.438	0.651
sufE; cysteine desulfuration protein SufE	-0.230	0.296	0.438	0.651
sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]	-0.230	0.296	0.438	0.651
surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8]	-0.230	0.296	0.438	0.651
surE; 5’-nucleotidase [EC:3.1.3.5]	-0.230	0.296	0.438	0.651
tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]	-0.230	0.296	0.438	0.651
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]	-0.227	0.333	0.497	0.651
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]	0.358	0.550	0.516	0.651
tagF; CDP-glycerol glycerophosphotransferase [EC:2.7.8.12]	0.092	1.404	0.948	0.986
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]	-0.230	0.296	0.438	0.651
tatA; sec-independent protein translocase protein TatA	-0.520	0.870	0.551	0.683
tatC; sec-independent protein translocase protein TatC	-0.520	0.870	0.551	0.683
tatD; TatD DNase family protein [EC:3.1.21.-]	-0.234	0.283	0.408	0.651
TC.AGCS; alanine or glycine:cation symporter, AGCS family	-0.045	0.351	0.898	0.972
TC.BASS; bile acid:Na+ symporter, BASS family	-0.228	0.293	0.437	0.651
TC.CIC; chloride channel protein, CIC family	-0.230	0.296	0.438	0.651
TC.CPA1; monovalent cation:H+ antiporter, CPA1 family	-2.232	1.933	0.250	0.651
TC.FEV.OM; iron complex outermembrane recepter protein	-0.224	0.298	0.453	0.651
TC.FEV.OM2, cirA, cfrA, hmuR; outer membrane receptor for ferrienterochelin and colicins	-0.212	0.308	0.491	0.651
TC.FEV.OM3, tbpA, hemR, lbpA, hpuB, bhuR, hugA, hmbR; hemoglobin/transferrin/lactoferrin receptor protein	0.054	0.493	0.913	0.976
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family	-0.606	0.561	0.282	0.651
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family	-0.216	0.278	0.438	0.651
TC.KEF; monovalent cation:H+ antiporter-2, CPA2 family	-0.187	0.310	0.548	0.681
TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family	-0.227	0.307	0.462	0.651
TC.NSS; neurotransmitter:Na+ symporter, NSS family	-0.242	0.316	0.446	0.651
TC.PIT; inorganic phosphate transporter, PiT family	2.304	1.989	0.248	0.651
TC.POT; proton-dependent oligopeptide transporter, POT family	-0.230	0.296	0.438	0.651
TC.SSS; solute:Na+ symporter, SSS family	-0.692	0.616	0.263	0.651
TC.SULP; sulfate permease, SulP family	-0.746	1.115	0.505	0.651
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family	-0.247	0.568	0.664	0.776
tdk, TK; thymidine kinase [EC:2.7.1.21]	-0.230	0.296	0.438	0.651
terC; tellurite resistance protein TerC	-0.625	0.575	0.278	0.651
tetM, tetO; ribosomal protection tetracycline resistance protein	-0.388	0.498	0.437	0.651
tex; protein Tex	-0.196	0.300	0.514	0.651
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29]	-0.230	0.296	0.438	0.651
THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]	0.014	0.383	0.970	0.998
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17]	0.014	0.383	0.970	0.998
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]	-0.134	0.312	0.669	0.779
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	-0.063	0.337	0.853	0.928
thiG; thiazole synthase [EC:2.8.1.10]	18.519	3411.091	0.996	0.998
thiH; 2-iminoacetate synthase [EC:4.1.99.19]	18.519	3411.091	0.996	0.998
thiJ; protein deglycase [EC:3.5.1.124]	-0.230	0.296	0.438	0.651
thiL; thiamine-monophosphate kinase [EC:2.7.4.16]	-0.230	0.296	0.438	0.651
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2]	-0.198	0.307	0.519	0.653
thiS; sulfur carrier protein	18.519	3411.091	0.996	0.998
thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]	-0.274	0.307	0.374	0.651
thrC; threonine synthase [EC:4.2.3.1]	-0.606	0.561	0.282	0.651
thyA, TYMS; thymidylate synthase [EC:2.1.1.45]	-0.172	0.309	0.579	0.705
thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148]	-0.625	0.575	0.278	0.651
tig; trigger factor	-0.230	0.296	0.438	0.651
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	-0.230	0.296	0.438	0.651
tnaA; tryptophanase [EC:4.1.99.1]	-0.221	0.572	0.699	0.797
tolA; colicin import membrane protein	-0.164	0.315	0.604	0.723
tolC; outer membrane protein	-0.590	0.508	0.248	0.651
tonB; periplasmic protein TonB	-0.185	0.276	0.505	0.651
topA; DNA topoisomerase I [EC:5.99.1.2]	-0.230	0.296	0.438	0.651
topB; DNA topoisomerase III [EC:5.99.1.2]	-0.314	0.345	0.363	0.651
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]	-0.240	0.307	0.435	0.651
tpx; thiol peroxidase, atypical 2-Cys peroxiredoxin [EC:1.11.1.15]	-0.754	1.120	0.502	0.651
treS; maltose alpha-D-glucosyltransferase / alpha-amylase [EC:5.4.99.16 3.2.1.1]	-0.629	0.781	0.422	0.651
trkA, ktrA; trk system potassium uptake protein	-0.230	0.296	0.438	0.651
trkH, trkG, ktrB; trk system potassium uptake protein	-0.230	0.296	0.438	0.651
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]	-0.230	0.296	0.438	0.651
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]	-0.230	0.296	0.438	0.651
troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator	0.038	0.480	0.937	0.977
trpA; tryptophan synthase alpha chain [EC:4.2.1.20]	-0.089	1.133	0.938	0.977
trpB; tryptophan synthase beta chain [EC:4.2.1.20]	-0.229	0.301	0.447	0.651
trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48]	-0.376	0.442	0.397	0.651
trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18]	-0.089	1.133	0.938	0.977
trpE; anthranilate synthase component I [EC:4.1.3.27]	-0.089	1.133	0.938	0.977
trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24]	-0.219	0.301	0.468	0.651
trpG; anthranilate synthase component II [EC:4.1.3.27]	-0.167	0.324	0.608	0.725
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]	-0.230	0.296	0.438	0.651
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]	-0.230	0.296	0.438	0.651
trxA; thioredoxin 1	-0.230	0.296	0.438	0.651
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]	-0.230	0.296	0.438	0.651
tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB	-0.230	0.296	0.438	0.651
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]	-0.230	0.296	0.438	0.651
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE	-0.230	0.296	0.438	0.651
tsf, TSFM; elongation factor Ts	-0.230	0.296	0.438	0.651
TSTA3, fcl; GDP-L-fucose synthase [EC:1.1.1.271]	-0.230	0.296	0.438	0.651
tuf, TUFM; elongation factor Tu	-0.230	0.296	0.438	0.651
typA, bipA; GTP-binding protein	-0.230	0.296	0.438	0.651
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	-0.230	0.296	0.438	0.651
udk, UCK; uridine kinase [EC:2.7.1.48]	-0.230	0.296	0.438	0.651
udp, UPP; uridine phosphorylase [EC:2.4.2.3]	-0.230	0.296	0.438	0.651
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	-0.219	0.308	0.477	0.651
umuC; DNA polymerase V	-0.183	0.301	0.543	0.678
umuD; DNA polymerase V [EC:3.4.21.-]	-2.933	2.379	0.219	0.651
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]	-0.204	0.307	0.507	0.651
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]	-0.230	0.296	0.438	0.651
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]	-0.230	0.296	0.438	0.651
URA4, pyrC; dihydroorotase [EC:3.5.2.3]	-0.220	0.308	0.477	0.651
utp; urea transporter	-17.599	3454.822	0.996	0.998
uup; ABC transport system ATP-binding/permease protein	-0.220	0.308	0.477	0.651
uvrA; excinuclease ABC subunit A	-0.215	0.290	0.459	0.651
uvrB; excinuclease ABC subunit B	-0.230	0.296	0.438	0.651
uvrC; excinuclease ABC subunit C	-0.230	0.296	0.438	0.651
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]	-0.254	0.306	0.407	0.651
uxaA; altronate hydrolase [EC:4.2.1.7]	-0.676	0.652	0.302	0.651
uxaB; tagaturonate reductase [EC:1.1.1.58]	-0.676	0.652	0.302	0.651
uxaC; glucuronate isomerase [EC:5.3.1.12]	-0.839	0.582	0.151	0.651
UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35]	-0.137	0.613	0.823	0.900
uxuA; mannonate dehydratase [EC:4.2.1.8]	-0.692	0.616	0.263	0.651
uxuB; fructuronate reductase [EC:1.1.1.57]	-0.677	0.652	0.301	0.651
vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]	-0.199	0.288	0.490	0.651
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]	-0.230	0.296	0.438	0.651
vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]	-0.298	0.485	0.540	0.676
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	-0.230	0.296	0.438	0.651
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-]	-0.076	0.332	0.819	0.899
wcaJ; putative colanic acid biosysnthesis UDP-glucose lipid carrier transferase	-0.429	0.535	0.425	0.651
wcaK, amsJ; colanic acid/amylovoran biosynthesis protein	2.304	1.989	0.248	0.651
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14]	-0.287	0.294	0.330	0.651
xanP; xanthine permease XanP	-0.131	0.310	0.674	0.784
xapB; MFS transporter, NHS family, xanthosine permease	0.027	0.484	0.955	0.992
xerC; integrase/recombinase XerC	-0.230	0.296	0.438	0.651
xerD; integrase/recombinase XerD	-0.230	0.296	0.438	0.651
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	-1.535	1.399	0.274	0.651
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]	-0.156	0.300	0.605	0.723
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]	-0.230	0.296	0.438	0.651
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]	-0.230	0.296	0.438	0.651
xylA; xylose isomerase [EC:5.3.1.5]	-0.092	1.135	0.935	0.977
xylB, XYLB; xylulokinase [EC:2.7.1.17]	-0.546	0.585	0.352	0.651
xylE; MFS transporter, SP family, xylose:H+ symportor	0.154	1.349	0.909	0.976
xylS, yicI; alpha-D-xyloside xylohydrolase [EC:3.2.1.177]	-0.603	0.561	0.284	0.651
yaeR; glyoxylase I family protein	18.519	3411.091	0.996	0.998
yafQ; mRNA interferase YafQ [EC:3.1.-.-]	-0.737	0.680	0.280	0.651
yajC; preprotein translocase subunit YajC	-0.230	0.296	0.438	0.651
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]	-0.230	0.296	0.438	0.651
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]	-0.754	1.120	0.502	0.651
ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein	-0.213	0.325	0.513	0.651
ybdG, mscM; miniconductance mechanosensitive channel	-0.223	0.302	0.460	0.651
ybeB; ribosome-associated protein	-0.230	0.296	0.438	0.651
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]	-0.370	0.319	0.249	0.651
ycaJ; putative ATPase	-0.230	0.296	0.438	0.651
ychF; ribosome-binding ATPase	-0.230	0.296	0.438	0.651
yfbK; Ca-activated chloride channel homolog	-0.248	0.303	0.415	0.651
yfiC, trmX; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223]	-0.230	0.296	0.438	0.651
yfiH; polyphenol oxidase [EC:1.10.3.-]	-0.230	0.296	0.438	0.651
yggS, PROSC; PLP dependent protein	-0.230	0.296	0.438	0.651
yhbH; putative sigma-54 modulation protein	-0.263	0.312	0.401	0.651
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase	-0.230	0.296	0.438	0.651
yjbB; phosphate:Na+ symporter	-0.230	0.296	0.438	0.651
yjdF; putative membrane protein	-0.084	0.350	0.811	0.894
yoeB; toxin YoeB [EC:3.1.-.-]	0.112	0.479	0.816	0.896
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]	-0.230	0.296	0.438	0.651
yraN; putative endonuclease	-0.230	0.296	0.438	0.651
yrbG; cation:H+ antiporter	-0.156	0.300	0.605	0.723
ytfE, scdA; regulator of cell morphogenesis and NO signaling	-0.216	0.284	0.448	0.651
zapA; cell division protein ZapA	-0.219	0.301	0.468	0.651
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5]	-0.201	0.284	0.481	0.651
znuA; zinc transport system substrate-binding protein	-0.352	0.456	0.441	0.651
znuB; zinc transport system permease protein	-0.452	0.409	0.271	0.651
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-]	-0.452	0.409	0.271	0.651
zraR, hydG; two-component system, NtrC family, response regulator HydG	-0.512	0.991	0.606	0.723

# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ko_stratefied_prevo_data_results.csv", row.names = F)

Session information

sessionInfo()

R version 4.0.5 (2021-03-31)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19042)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.1252 
[2] LC_CTYPE=English_United States.1252   
[3] LC_MONETARY=English_United States.1252
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.1252    

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] cowplot_1.1.1     dendextend_1.14.0 ggdendro_0.1.22   reshape2_1.4.4   
 [5] car_3.0-10        carData_3.0-4     gvlma_1.0.0.3     patchwork_1.1.1  
 [9] viridis_0.5.1     viridisLite_0.3.0 gridExtra_2.3     xtable_1.8-4     
[13] kableExtra_1.3.4  MASS_7.3-53.1     data.table_1.14.0 readxl_1.3.1     
[17] forcats_0.5.1     stringr_1.4.0     dplyr_1.0.5       purrr_0.3.4      
[21] readr_1.4.0       tidyr_1.1.3       tibble_3.1.0      ggplot2_3.3.3    
[25] tidyverse_1.3.0   lmerTest_3.1-3    lme4_1.1-26       Matrix_1.3-2     
[29] vegan_2.5-7       lattice_0.20-41   permute_0.9-5     phyloseq_1.34.0  
[33] workflowr_1.6.2  

loaded via a namespace (and not attached):
  [1] minqa_1.2.4         colorspace_2.0-0    rio_0.5.26         
  [4] ellipsis_0.3.1      rprojroot_2.0.2     XVector_0.30.0     
  [7] fs_1.5.0            rstudioapi_0.13     farver_2.1.0       
 [10] fansi_0.4.2         lubridate_1.7.10    xml2_1.3.2         
 [13] codetools_0.2-18    splines_4.0.5       knitr_1.31         
 [16] ade4_1.7-16         jsonlite_1.7.2      nloptr_1.2.2.2     
 [19] broom_0.7.5         cluster_2.1.1       dbplyr_2.1.0       
 [22] BiocManager_1.30.10 compiler_4.0.5      httr_1.4.2         
 [25] backports_1.2.1     assertthat_0.2.1    cli_2.3.1          
 [28] later_1.1.0.1       htmltools_0.5.1.1   prettyunits_1.1.1  
 [31] tools_4.0.5         igraph_1.2.6        gtable_0.3.0       
 [34] glue_1.4.2          Rcpp_1.0.6          Biobase_2.50.0     
 [37] cellranger_1.1.0    jquerylib_0.1.3     vctrs_0.3.6        
 [40] Biostrings_2.58.0   rhdf5filters_1.2.0  multtest_2.46.0    
 [43] svglite_2.0.0       ape_5.4-1           nlme_3.1-152       
 [46] iterators_1.0.13    xfun_0.21           ps_1.6.0           
 [49] openxlsx_4.2.3      rvest_1.0.0         lifecycle_1.0.0    
 [52] statmod_1.4.35      zlibbioc_1.36.0     scales_1.1.1       
 [55] hms_1.0.0           promises_1.2.0.1    parallel_4.0.5     
 [58] biomformat_1.18.0   rhdf5_2.34.0        curl_4.3           
 [61] yaml_2.2.1          sass_0.3.1          stringi_1.5.3      
 [64] highr_0.8           S4Vectors_0.28.1    foreach_1.5.1      
 [67] BiocGenerics_0.36.0 zip_2.1.1           boot_1.3-27        
 [70] systemfonts_1.0.1   rlang_0.4.10        pkgconfig_2.0.3    
 [73] evaluate_0.14       Rhdf5lib_1.12.1     labeling_0.4.2     
 [76] tidyselect_1.1.0    plyr_1.8.6          magrittr_2.0.1     
 [79] R6_2.5.0            IRanges_2.24.1      generics_0.1.0     
 [82] DBI_1.1.1           foreign_0.8-81      pillar_1.5.1       
 [85] haven_2.3.1         whisker_0.4         withr_2.4.1        
 [88] mgcv_1.8-34         abind_1.4-5         survival_3.2-10    
 [91] modelr_0.1.8        crayon_1.4.1        utf8_1.1.4         
 [94] rmarkdown_2.7       progress_1.2.2      grid_4.0.5         
 [97] git2r_0.28.0        webshot_0.5.2       reprex_1.0.0       
[100] digest_0.6.27       httpuv_1.5.5        numDeriv_2016.8-1.1
[103] stats4_4.0.5        munsell_0.5.0       bslib_0.2.4